Gene

pmela

ID
ZDB-GENE-030131-9818
Name
premelanosome protein a
Symbol
pmela Nomenclature History
Previous Names
  • pmel17 (1)
  • cb397 (1)
  • fading vision
  • fdv
  • sb:cb397
  • silva
  • wu:fc11g11
  • wu:fj24g11
  • zgc:136622
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable ATP binding activity and metal ion binding activity. Acts upstream of or within several processes, including amyloid fibril formation; melanocyte differentiation; and melanosome organization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in melanosome. Predicted to be integral component of plasma membrane. Is expressed in several structures, including eye; immature eye; neural crest; notochord; and pigment cell. Orthologous to human PMEL (premelanosome protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pmela Human Ortholog
No data available
Associated With pmela Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000601 PKD domain
Domain IPR011761 ATP-grasp fold
Domain IPR022409 PKD/Chitinase domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR035986 PKD domain superfamily
Domain Details Per Protein
Protein Length ATP-grasp fold Immunoglobulin-like fold PKD/Chitinase domain PKD domain PKD domain superfamily
UniProtKB:Q5R2V2 251
UniProtKB:F1R9D2 825
UniProtKB:A0A0R4IIU6 779
UniProtKB:Q1ECY0 825
UniProtKB:B3DJD9 845
UniProtKB:A2VD17 841
UniProtKB:Q4VW61 845
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations