ZFIN ID: ZDB-GENE-001205-2
Gene Name: aldehyde oxidase 5
Gene Symbol: aox5    Nomenclature History

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Previous Names: aox2 (1), aox3 (1), aoxa (1), aox alpha (1), etID47878.22 (1), fc18g02, wu:fc18g02, xdh

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have flavin adenine dinucleotide binding activity and xanthine dehydrogenase activity. Predicted to be involved in xanthine catabolic process. Localizes to cytoplasm. Is expressed in several structures, including fin; neural crest; pigment cell; post-vent region; and xanthoblast. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human AOX1 (aldehyde oxidase 1).
Genome Resources: Alliance (1),  Gene:64265 (1),  Ensembl(GRCz11):ENSDARG00000071475 (2)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH aox5 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH aox5 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component cytoplasm (more)
Molecular Function 2 iron, 2 sulfur cluster binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA aox5-201 (1)    Ensembl 4033
ncRNA aox5-002 (1)    Ensembl 542
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM aox5
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(aox5:PALM-EGFP) aox5 EGFPPALM Danio rerio 1 4
Tg(aox5:PALM-GFP) aox5 GFP Danio rerio 1 4
Tg(aox5:TETA-GBD,TETRE:NLS-Venus-2A-dnHsa.CDC42) aox5TETRE 2ANLSTETA-GBDVenus Danio rerioHomo sapiens 1 1
MARKER RELATIONSHIPS
aox5 Contained in: [BAC] CH211-246M6 (1)
aox5 Encodes: [EST] eu1094 (1), fc18g02 (2)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001278796 (1)
Genomic GenBank:BX649296 (1) 175492 nt
Select Tool
Polypeptide UniProtKB:M1ZMM0 (1) 1336 aa
Sequence Information (all 13)
ORTHOLOGY for aox5 ( Chr: 22 )
CITATIONS (55)