Gene
aox5
- ID
- ZDB-GENE-001205-2
- Name
- aldehyde oxidase 5
- Symbol
- aox5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have flavin adenine dinucleotide binding activity and xanthine dehydrogenase activity. Predicted to be involved in xanthine catabolic process. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Is expressed in several structures, including fin; neural crest; pigment cell; post-vent region; and xanthoblast. Orthologous to human AOX1 (aldehyde oxidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1094 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR006058 | 2Fe-2S ferredoxin, iron-sulphur binding site |
| Domain | IPR000674 | Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead |
| Domain | IPR001041 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| Domain | IPR002346 | Molybdopterin dehydrogenase, FAD-binding |
| Domain | IPR002888 | [2Fe-2S]-binding |
| Domain | IPR005107 | CO dehydrogenase flavoprotein, C-terminal |
| Domain | IPR008274 | Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain |
| Domain | IPR014307 | Xanthine dehydrogenase, small subunit |
| Domain | IPR016166 | FAD-binding domain, PCMH-type |
| Domain | IPR046867 | Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain |
| Family | IPR016208 | Aldehyde oxidase/xanthine dehydrogenase-like |
| Homologous_superfamily | IPR012675 | Beta-grasp domain superfamily |
| Homologous_superfamily | IPR016167 | FAD-binding, type PCMH, subdomain 1 |
| Homologous_superfamily | IPR016169 | FAD-binding, type PCMH, subdomain 2 |
| Homologous_superfamily | IPR036010 | 2Fe-2S ferredoxin-like superfamily |
| Homologous_superfamily | IPR036318 | FAD-binding, type PCMH-like superfamily |
| Homologous_superfamily | IPR036683 | CO dehydrogenase flavoprotein, C-terminal domain superfamily |
| Homologous_superfamily | IPR036856 | Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily |
| Homologous_superfamily | IPR036884 | [2Fe-2S]-binding domain superfamily |
| Homologous_superfamily | IPR037165 | Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily |
Domain Details Per Protein
| Protein | Length | [2Fe-2S]-binding | [2Fe-2S]-binding domain superfamily | 2Fe-2S ferredoxin, iron-sulphur binding site | 2Fe-2S ferredoxin-like superfamily | 2Fe-2S ferredoxin-type iron-sulfur binding domain | Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead | Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily | Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain | Aldehyde oxidase/xanthine dehydrogenase-like | Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily | Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain | Beta-grasp domain superfamily | CO dehydrogenase flavoprotein, C-terminal | CO dehydrogenase flavoprotein, C-terminal domain superfamily | FAD-binding domain, PCMH-type | FAD-binding, type PCMH-like superfamily | FAD-binding, type PCMH, subdomain 1 | FAD-binding, type PCMH, subdomain 2 | Molybdopterin dehydrogenase, FAD-binding | Xanthine dehydrogenase, small subunit |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:M1ZMM0
|
1336 |
Interactions and Pathways
No data available
Plasmids
No data available