Gene

tyr

ID

ZDB-GENE-991026-3

Name

tyrosinase

Symbol

tyr Nomenclature History

Previous Names

oca1
sandy
sdy
tyra (1)
zgc:109705

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Enables catechol oxidase activity. Acts upstream of or within several processes, including dopamine biosynthetic process from tyrosine; iridophore differentiation; and melanosome organization. Predicted to be located in melanosome membrane. Is expressed in several structures, including eye; male organism; melanoblast; neural crest; and presumptive retinal pigmented epithelium. Used to study color blindness and oculocutaneous albinism. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (tyrosinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

35 figures from 30 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 32 figures from 18 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tyr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
oculocutaneous albinism type IA	Alliance	Albinism, oculocutaneous, type IA	203100
oculocutaneous albinism type IB	Alliance	Albinism, oculocutaneous, type IB	606952
		[Skin/hair/eye pigmentation 3, blue/green eyes]	601800
		[Skin/hair/eye pigmentation 3, light/dark/freckling skin]	601800
		{Melanoma, cutaneous malignant, susceptibility to, 8}	601800

Associated With tyr Via Experimental Models

Human Disease	Fish	Conditions	Citations
oculocutaneous albinism	tyr^{ck112a/ck112a}	standard conditions	Park et al., 2016
color blindness	tyr^{ck112a/ck112a}	standard conditions	Park et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002227	Tyrosinase copper-binding domain
Family	IPR050316	Tyrosinase and Hemocyanin
Homologous_superfamily	IPR008922	Di-copper centre-containing domain superfamily

Domain Details Per Protein

Protein	Length	Di-copper centre-containing domain superfamily	Tyrosinase and Hemocyanin	Tyrosinase copper-binding domain
UniProtKB:A0A8M1PAD4 InterPro	534

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tyr-201 (1) Ensembl	Ensembl		1,948 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:pT7tyrgRNA

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations