Gene
tyr
- ID
- ZDB-GENE-991026-3
- Name
- tyrosinase
- Symbol
- tyr Nomenclature History
- Previous Names
-
- oca1
- sandy
- sdy
- tyra (1)
- zgc:109705
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables catechol oxidase activity. Acts upstream of or within several processes, including dopamine biosynthetic process from tyrosine; iridophore differentiation; and melanosome organization. Predicted to be located in melanosome membrane. Is expressed in several structures, including eye; male organism; melanoblast; neural crest; and presumptive retinal pigmented epithelium. Used to study color blindness and oculocutaneous albinism. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (tyrosinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 32 figures from 18 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| oculocutaneous albinism type IA | Alliance | Albinism, oculocutaneous, type IA | 203100 |
| oculocutaneous albinism type IB | Alliance | Albinism, oculocutaneous, type IB | 606952 |
| [Skin/hair/eye pigmentation 3, blue/green eyes] | 601800 | ||
| [Skin/hair/eye pigmentation 3, light/dark/freckling skin] | 601800 | ||
| {Melanoma, cutaneous malignant, susceptibility to, 8} | 601800 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| oculocutaneous albinism | tyrck112a/ck112a | standard conditions | Park et al., 2016 |
| color blindness | tyrck112a/ck112a | standard conditions | Park et al., 2016 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M1PAD4 | InterPro | 534 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | aj250302 | Camp et al., 2001 | |
| Has Artifact | cDNA | MGC:109705 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131013 (1) | 1955 nt | ||
| Genomic | GenBank:CU856545 (1) | 111121 nt | ||
| Polypeptide | UniProtKB:A0A8M1PAD4 (1) | 534 aa |
- Krueger, C.J., Dai, Z., Zhu, C., Zhang, B. (2024) Heritable CRISPR Mutagenesis of Essential Maternal Effect Genes as a Simple Tool for Sustained Population Suppression of Invasive Species in a Zebrafish Model. Zebrafish. 21(4):279-286
- Locubiche, S., Ordóñez, V., Abad, E., Scotto di Mase, M., Di Donato, V., De Santis, F. (2024) A Zebrafish-Based Platform for High-Throughput Epilepsy Modeling and Drug Screening in F0. International Journal of Molecular Sciences. 25(5):
- Ma, J., Zhang, W., Rahimialiabadi, S., Ganesh, N.U., Sun, Z., Parvez, S., Peterson, R.T., Yeh, J.J. (2024) Instantaneous visual genotyping and facile site-specific transgenesis via CRISPR-Cas9 and phiC31 integrase. Biology Open. 13(9):
- Noonan, H.R., Thornock, A.M., Barbano, J., Xifaras, M.E., Baron, C.S., Yang, S., Koczirka, K., McConnell, A.M., Zon, L.I. (2024) A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma. eLIFE. 13:
- Ujiie, H., Nishiya, N., Yamamoto, A., Takada, T., Onodera, M., Sasaki, A., Oikawa, T. (2024) Dexamethasone reduces cisplatin-induced hair cell damage by inducing cisplatin resistance through metallothionein-2. Cancer Chemotherapy and Pharmacology. 94(4):561-569
- Ye, X., Lin, J., Chen, Q., Lv, J., Liu, C., Wang, Y., Wang, S., Wen, X., Lin, F. (2024) An Efficient Vector-Based CRISPR/Cas9 System in Zebrafish Cell Line. Marine biotechnology (New York, N.Y.). 26(3):588-598
- Zhang, Y., Liu, Y., Qin, W., Zheng, S., Xiao, J., Xia, X., Yuan, X., Zeng, J., Shi, Y., Zhang, Y., Ma, H., Varshney, G.K., Fei, J.F., Liu, Y. (2024) Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish. Nature communications. 15:95269526
- Guo, Q.Q., Yuan, Y.Y., Sun, T.W., Wu, S.J., Li, X.H., Zhao, H.S. (2023) Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway. European review for medical and pharmacological sciences. 27:425442684254-4268
- Huttner, I.G., Santiago, C.F., Jacoby, A., Cheng, D., Trivedi, G., Cull, S., Cvetkovska, J., Chand, R., Berger, J., Currie, P.D., Smith, K.A., Fatkin, D. (2023) Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish. Journal of cardiovascular development and disease. 10(10):
- Katkat, E., Demirci, Y., Heger, G., Karagulle, D., Papatheodorou, I., Brazma, A., Ozhan, G. (2023) Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells. Frontiers in cell and developmental biology. 11:12979101297910
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