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Gene

tyrp1b

ID
ZDB-GENE-040718-249
Name
tyrosinase-related protein 1b
Symbol
tyrp1b Nomenclature History
Previous Names
  • tyrp1 (1)
  • hm:zeh0659
  • oca3
  • zgc:100893
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable oxidoreductase activity. Acts upstream of or within several processes, including melanosome organization; response to thyroid hormone; and retinal pigment epithelium development. Predicted to be located in melanosome membrane. Predicted to be integral component of membrane. Predicted to be active in melanosome. Is expressed in several structures, including eye; hatching gland; immature eye; melanoblast; and pigment cell. Human ortholog(s) of this gene implicated in oculocutaneous albinism; oculocutaneous albinism type III; and pigmentation disease. Orthologous to human TYRP1 (tyrosinase related protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tyrp1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
oculocutaneous albinism type III Alliance Albinism, oculocutaneous, type III 203290
[Skin/hair/eye pigmentation, variation in, 11 (Melanesian blond hair)] 612271
Associated With tyrp1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002227 Tyrosinase copper-binding domain
Homologous_superfamily IPR008922 Uncharacterised domain, di-copper centre
Domain Details Per Protein
Protein Length Tyrosinase copper-binding domain Uncharacterised domain, di-copper centre
UniProtKB:Q6DGE4 526
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations