Gene
csnk1a1
- ID
- ZDB-GENE-020419-19
- Name
- casein kinase 1, alpha 1
- Symbol
- csnk1a1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables protein serine/threonine kinase activity. Acts upstream of or within heart development and peptidyl-serine phosphorylation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; head; otic vesicle; pectoral fin; and solid lens vesicle. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-csnk1a1 | Zebrafish Nomenclature Committee | |
| MO1-csnk1a1 | N/A | Kuo et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050235 | Casein Kinase 1 Ser/Thr Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Casein Kinase 1 Ser/Thr Protein Kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JHE0 | InterPro | 365 | |||||
| UniProtKB:Q8JHD9 | InterPro | 353 | |||||
| UniProtKB:Q8JG73 | InterPro | 337 | |||||
| UniProtKB:Q8JGT0 | InterPro | 325 | |||||
| UniProtKB:A0A2R8Q421 | InterPro | 364 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
csnk1a1-205
(1)
|
Ensembl | 876 nt | ||
| mRNA |
csnk1a1-201
(1)
|
Ensembl | 2,471 nt | ||
| mRNA |
csnk1a1-202
(1)
|
Ensembl | 2,341 nt | ||
| mRNA |
csnk1a1-203
(1)
|
Ensembl | 2,267 nt | ||
| mRNA |
csnk1a1-206
(1)
|
Ensembl | 2,340 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-315L8 | ZFIN Curated Data | |
| Contained in | BAC | CH211-195B11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-15F11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-184E24 | ZFIN Curated Data | |
| Contains | SNP | rs3728663 | ZFIN Curated Data | |
| Encodes | BAC END | zk18h6.sp6 | ||
| Encodes | EST | eu369 | Thisse et al., 2005 | |
| Encodes | EST | eu866 | Thisse et al., 2005 | |
| Encodes | EST | fb06f03 | ||
| Encodes | EST | fb65a02 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152951 (1) | 2348 nt | ||
| Genomic | GenBank:BX465201 (1) | 262688 nt | ||
| Polypeptide | UniProtKB:Q8JHE0 (1) | 365 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Nolte, H., Hölper, S., Housley, M.P., Islam, S., Piller, T., Konzer, A., Stainier, D.Y., Braun, T., Krüger, M. (2015) Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Proteomics. 15(4):739-51
- Kuo, M.W., Lou, S.W., Chung, B.C. (2014) Hedgehog-PKA Signaling and gnrh3 Regulate the Development of Zebrafish gnrh3 Neurons. PLoS One. 9:e95545
- Wiweger, M.I., Zhao, Z., van Merkesteyn, R.J., Roehl, H.H., and Hogendoornm, P.C. (2012) HSPG-Deficient Zebrafish Uncovers Dental Aspect of Multiple Osteochondromas. PLoS One. 7(1):e29734
- Barresi, M.J., Burton, S., Dipietrantonio, K., Amsterdam, A., Hopkins, N., and Karlstrom, R.O. (2010) Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(10):2603-2618
- Milan, D.J., Kim, A.M., Winterfield, J.R., Jones, I.L., Pfeufer, A., Sanna, S., Arking, D.E., Amsterdam, A.H., Sabeh, K.M., Mably, J.D., Rosenbaum, D.S., Peterson, R.T., Chakravarti, A., Kääb, S., Roden, D.M., and MacRae, C.A. (2009) Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization. Circulation. 120(7):553-559
- De Wit, M., Keil, D., Remmerie, N., Ven, K.V., Brandhof, E.J., Knapen, D., Witters, E., and Coen, W.D. (2008) Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches. Chemosphere. 74(1):96-105
- Albornoz, A., Yáñez, J.M., Foerster, C., Aguirre, C., Pereiro, L., Burzio, V., Moraga, M., Reyes, A.E., and Antonelli, M. (2007) The CK1 gene family: expression patterning in zebrafish development. Biological research. 40(2):251-266
- Nissen, R.M., Amsterdam, A., and Hopkins, N. (2006) A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for Endothelin-1 expression. BMC Developmental Biology. 6:28
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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