Fig. 6 - Supplemental 6

Molecular docking binding poses of DC661 and HCQ with the VPS37 family. (A) Structural superposition of VPS37C with other members of the VPS37A/B/D family reveals high structural similarities within the VPS37 family. The crystal structure of the ESCRT-1 complex from yeast (2P22) is shown on the far right. STP22 and SRN2 are yeast orthologs of VPS23(TSG101) and VPS37, respectively. (B) Molecular docking binding poses of DC661 with the VPS37 family. (C) Molecular docking binding poses of HCQ with the VPS37 family.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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