FIGURE
Fig. 6 - Supplemental 1
- ID
- ZDB-FIG-250204-37
- Publication
- Sun et al., 2024 - Target protein identification in live cells and organisms with a non-diffusive proximity tagging system
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Fig. 6 - Supplemental 1
A DC661-HTL derivative, DC661-H1, is highly active as an autophagy inhibitor. (A) The chemical structure of DC661-H1, annotated with key functional groups. (B) Autophagy inhibition by DC661-H1 was assessed through the increased levels of the LC3-II band by western blot using an anti-LC3B antibody. DC661-H1 significantly increased the levels of LC3-II in both HEK293T and A375 cells, comparably to HCQ and DC660, an analog of DC661 that lacks a methyl group at the central linker nitrogen. Cells were treated with the indicated concentration of each compound for 12 hr prior to western blot analysis. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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