ZFIN ID: ZDB-LAB-020513-1
Appel Lab
PI/Director: Appel, Bruce
Contact Person: Appel, Bruce
Email: bruce.appel@ucdenver.edu
URL: http://www.uchsc.edu/cdb/People/Faculty/appel.html
Address: Department of Pediatrics University of Colorado Denver Mail Stop 8108 RC1, Rm L18-12115 12801 East 17th Avenue Aurora CO 80045 USA
Country: United States
Phone: 303-724-3465
Line Designation: co

Show all 47 genomic features


Langworthy, Melissa Post-Doc Ravanelli, Andrew M. Post-Doc Roberts, Randy Graduate Student
Simmons, Tim Graduate Student Zannino, Denise Graduate Student Casper, Sarah Research Staff
Kearns, Christina Research Staff

Stenzel, A., Mumme-Monheit, A., Sucharov, J., Walker, M., Mitchell, J.M., Appel, B., Nichols, J.T. (2022) Distinct and redundant roles for zebrafish her genes during mineralization and craniofacial patterning. Frontiers in endocrinology. 13:10338431033843
Fedder-Semmes, K.N., Appel, B. (2021) The Akt-mTOR pathway drives myelin sheath growth by regulating cap-dependent translation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(41):8532-8544
Scott, K., O'Rourke, R., Winkler, C.C., Kearns, C.A., Appel, B. (2021) Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations. Developmental Biology. 479:37-50
Doll, C.A., Scott, K., Appel, B. (2021) Fmrp regulates oligodendrocyte lineage cell specification and differentiation. Glia. 69(10):2349-2361
Kearns, C.A., Walker, M., Ravanelli, A.M., Scott, K., Arzbecker, M.R., Appel, B. (2021) Zebrafish spinal cord oligodendrocyte formation requires boc function. Genetics. 218(4):
Yergert, K.M., Doll, C.A., O'Rouke, R., Hines, J.H., Appel, B. (2021) Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo. PLoS Biology. 19:e3001053
Terhune, E.A., Cuevas, M.T., Monley, A.M., Wethey, C.I., Chen, X., Cattel, M.V., Bayrak, M.N., Bland, M.R., Sutphin, B., Devon Trahan, G., Taylor, M.R.G., Niswander, L.A., Jones, K.L., Baschal, E.E., Antunes, L., Dobbs, M., Gurnett, C., Appel, B., Gray, R., Miller, N.H. (2020) Mutations in KIF7 Implicated in Idiopathic Scoliosis in Humans and Axial Curvatures in Zebrafish. Human Mutation. 42(4):392-407
Jewett, C.E., Appel, B.H., Prekeris, R. (2020) The Rab11 effectors Fip5 and Fip1 regulate zebrafish intestinal development. Biology Open. 9(10):
Scott, K., O'Rourke, R., Gillen, A., Appel, B. (2020) Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating Shh signaling response. Development (Cambridge, England). 147(16):
Hughes, A.N., Appel, B. (2020) Microglia phagocytose myelin sheaths to modify developmental myelination. Nature Neuroscience. 23(9):1055-1066
Doll, C.A., Yergert, K.M., Appel, B.H. (2019) The RNA binding protein fragile X mental retardation protein promotes myelin sheath growth. Glia. 68(3):495-508
Hughes, A.N., Appel, B. (2019) Oligodendrocytes express synaptic proteins that modulate myelin sheath formation. Nature communications. 10:4125
Ravanelli, A.M., Kearns, C.A., Powers, R.K., Wang, Y., Hines, J.H., Donaldson, M.J., Appel, B. (2018) Sequential Specification of Oligodendrocyte Lineage Cells by Distinct Levels of Hedgehog and Notch Signaling. Developmental Biology. 444(2):93-106
Quintana, A.M., Yu, H.C., Brebner, A., Pupavac, M., Geiger, E.A., Watson, A., Castro, V.L., Cheung, W., Chen, S.H., Watkins, D., Pastinen, T., Skovby, F., Appel, B., Rosenblatt, D.S., Shaikh, T.H. (2017) Mutations in THAP11 cause an inborn error of cobalamin metabolism and developmental abnormalities. Human molecular genetics. 26(15):2838-2849
Mathews, E.S., Appel, B. (2016) Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:7628-39
Hudish, L.I., Galati, D.F., Ravanelli, A.M., Pearson, C.G., Huang, P., Appel, B. (2016) miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development (Cambridge, England). 143(13):2292-304
Mathews, E.S., Appel, B. (2016) Oligodendrocyte differentiation. Methods in cell biology. 134:69-96
Ravanelli, A.M., Appel, B. (2015) Motor neurons and oligodendrocytes arise from distinct cell lineages by progenitor recruitment. Genes & Development. 29(23):2504-15
Kearns, C.A., Ravanelli, A.M., Cooper, K., Appel, B. (2015) Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:14861-71
Zannino, D.A., Sagerström, C.G. (2015) An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system. Neural Development. 10:24
Hines, J.H., Ravanelli, A.M., Schwindt, R., Scott, E.K., Appel, B. (2015) Neuronal activity biases axon selection for myelination in vivo. Nature Neuroscience. 18(5):683-9
Amin, S., Donaldson, I.J., Zannino, D.A., Hensman, J., Rattray, M., Losa, M., Spitz, F., Ladam, F., Sagerström, C., Bobola, N. (2015) Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Developmental Cell. 32:265-77
Yang, M.L., Shin, J., Kearns, C.A., Langworthy, M.M., Snell, H., Walker, M.B., Appel, B. (2015) CNS Myelination Requires Cytoplasmic Dynein Function. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(2):134-45
Blasky, A.J., Pan, L., Moens, C.B., Appel, B. (2014) Pard3 regulates contact between neural crest cells and the timing of Schwann cell differentiation but is not essential for neural crest migration or myelination. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(12):1511-23
Quintana, A.M., Geiger, E.A., Achilly, N., Rosenblatt, D.S., Maclean, K.N., Stabler, S.P., Artinger, K.B., Appel, B., Shaikh, T.H. (2014) Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating MMACHC expression. Developmental Biology. 396(1):94-106
Zannino, D.A., Downes, G.B., Sagerström, C.G. (2014) prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements. Developmental Biology. 390:247-60
Weicksel, S.E., Gupta, A., Zannino, D.A., Wolfe, S.A., Sagerström, C.G. (2014) Targeted germ line disruptions reveal general and species-specific roles for paralog group 1 hox genes in zebrafish. BMC Developmental Biology. 14:25
Mathews, E.S., Mawdsley, D.J., Walker, M., Hines, J.H., Pozzoli, M., Appel, B. (2014) Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:3402-12
Wang, Y., Pan, L., Moens, C.B., and Appel, B. (2014) Notch3 establishes brain vascular integrity by regulating pericyte number. Development (Cambridge, England). 141(2):307-317
Hudish, L.I., Blasky, A.J., and Appel, B. (2013) miR-219 Regulates Neural Precursor Differentiation by Direct Inhibition of Apical Par Polarity Proteins. Developmental Cell. 27(4):387-398
Langworthy, M.M., and Appel, B. (2012) Schwann cell myelination requires Dynein function. Neural Development. 7(1):37
Snyder, J.L., Kearns, C.A., and Appel, B. (2012) Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate. Neural Development. 7(1):15
Jao, L.E., Appel, B., and Wente, S.R. (2012) A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization. Development (Cambridge, England). 139(7):1316-1326
Zannino, D.A., Sagerström, C.C., and Appel, B. (2012) Olig2-expressing hindbrain cells are required for migrating facial motor neurons. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(2):315-326
Tep, C., Kim, M.L., Opincariu, L.I., Limpert, A.S., Chan, J.R., Appel, B., Carter, B.D., and Yoon, S.O. (2012) Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) at the onset of Schwann cell myelination through partitioning-defective 3 (Par3). The Journal of biological chemistry. 287(2):1600-8
Simmons, T., and Appel, B. (2012) Mutation of pescadillo Disrupts Oligodendrocyte Formation in Zebrafish. PLoS One. 7(2):e32317
Takada, N., and Appel, B. (2011) swap70 Promotes neural precursor cell cycle exit and oligodendrocyte formation. Molecular and cellular neurosciences. 48(3):225-35
Ravanelli, A.M., and Klingensmith, J. (2011) The Actin Nucleator Cordon-bleu is Required for Development of Motile Cilia in Zebrafish. Developmental Biology. 350(1):101-111
Takada, N., and Appel, B. (2010) Identification of genes expressed by zebrafish oligodendrocytes using a differential microarray screen. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(7):2041-2047
Takada, N., Kucenas, S., and Appel, B. (2010) Sox10 is necessary for oligodendrocyte survival following axon wrapping. Glia. 58(8):996-1006
Zhao, X., He, X., Han, X., Yu, Y., Ye, F., Chen, Y., Hoang, T., Xu, X., Mi, Q.S., Xin, M., Wang, F., Appel, B., and Lu, Q.R. (2010) MicroRNA-Mediated Control of Oligodendrocyte Differentiation. Neuron. 65(5):612-626
Ravanelli, A.M. (2010) Characterization of the Actin Nucleator Cordon-bleu in Zebrafish. Thesis.
Kucenas, S., Wang, W.D., Knapik, E.W., and Appel, B. (2009) A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(48):15187-15194
Roberts, R.K. (2009) Analysis of signaling pathways important in the specification and migration of oligodendrocyte progenitor cells in the zebrafish spinal cord. Ph.D. Thesis. :138p
Roberts, R.K., and Appel, B. (2009) Apical polarity protein PrkCi is necessary for maintenance of spinal cord precursors in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(7):1638-1648
Zannino, D.A., and Appel, B. (2009) Olig2+ precursors produce abducens motor neurons and oligodendrocytes in the zebrafish hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(8):2322-2333
Kim, H., Shin, J., Kim, S., Poling, J., Park, H.C., and Appel, B. (2008) Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(8):2081-2089
McFarland, K.A., Topczewska, J.M., Weidinger, G., Dorsky, R.I., and Appel, B. (2008) Hh and Wnt signaling regulate formation of olig2(+) neurons in the zebrafish cerebellum. Developmental Biology. 318(1):162-171
Kucenas, S., Snell, H., and Appel, B. (2008) nkx2.2a promotes specification and differentiation of a myelinating subset of oligodendrocyte lineage cells in zebrafish. Neuron glia biology. 4(2):71-81
Kucenas, S., Takada, N., Park, H.C., Woodruff, E., Broadie, K., and Appel, B. (2008) CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nature Neuroscience. 11(2):143-151
Sarmah, B., Winfrey, V.P., Olson, G.E., Appel, B., and Wente, S.R. (2007) A role for the inositol kinase Ipk1 in ciliary beating and length maintenance. Proceedings of the National Academy of Sciences of the United States of America. 104(50):19843-19848
Park, H.C., Shin, J., Roberts, R.K., and Appel, B. (2007) An olig2 reporter gene marks oligodendrocyte precursors in the postembryonic spinal cord of zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(12):3402-3407
Shin, J., Poling, J., Park, H.C., and Appel, B. (2007) Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish. Development (Cambridge, England). 134(10):1911-1920
Kirby, B.B., Takada, N., Latimer, A.J., Shin, J., Carney, T.J., Kelsh, R.N., and Appel, B. (2006) In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Nature Neuroscience. 9(12):1506-1511
Latimer, A.J., and Appel, B. (2006) Notch signaling regulates midline cell specification and proliferation in zebrafish. Developmental Biology. 298(2):392-402
Ng, A.N., de Jong-Curtain, T.A., Mawdsley, D.J., White, S.J., Shin, J., Appel, B., Dong, P.D., Stainier, D.Y., and Heath, J.K. (2005) Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis. Developmental Biology. 286(1):114-135
Park, H.C., Boyce, J., Shin, J., and Appel, B. (2005) Oligodendrocyte specification in zebrafish requires notch-regulated cyclin-dependent kinase inhibitor function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(29):6836-6844
Sarmah, B., Latimer, A.J., Appel, B., and Wente, S.R. (2005) Inositol polyphosphates regulate zebrafish left-right asymmetry. Developmental Cell. 9(1):133-145
Latimer, A.J., Shin, J., and Appel, B. (2005) her9 promotes floor plate development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 232(4):1098-1104
Park, H.C., Shin, J., and Appel, B. (2004) Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling. Development (Cambridge, England). 131(23):5959-5969
Garg, R., Geng, C.D., Miller, J.L., Callens, S., Tang, X., Appel, B., and Xu, B. (2004) Molecular Cloning and Characterization of the Catalytic Domain of Zebrafish Homologue of the Ataxia-Telangiectasia Mutated Gene. Molecular cancer research : MCR. 2(6):348-353
Appel, B., Marasco, P., McClung, L.E., and Latimer, A.J. (2003) lunatic fringe regulates delta-notch induction of hypochord in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(2):281-286
Park, H.-C. and Appel, B. (2003) Delta-Notch signaling regulates oligodendrocyte specification. Development (Cambridge, England). 130(16):3747-3755
Shin, J., Park, H.-C., Topczewska, J.M., Mawdsley, D.J., and Appel, B. (2003) Neural cell fate analysis in zebrafish using olig2 BAC transgenics. Methods in cell science : an official journal of the Society for In Vitro Biology. 25(1-2):7-14
Park, H.-C., Mehta, A., Richardson, J.S., and Appel, B. (2002) olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Developmental Biology. 248(2):356-368
Latimer, A.J., Dong, X., Markov, Y., and Appel, B. (2002) Delta-Notch signaling induces hypochord development in zebrafish. Development (Cambridge, England). 129(11):2555-2563
Appel, B. and Chitnis, A. (2002) Neurogenesis and specification of neuronal identity. Results and problems in cell differentiation. 40:237-251
Appel, B., Givan, L.A., and Eisen, J.S. (2001) Delta-Notch signaling and lateral inhibition in zebrafish spinal cord development. BMC Developmental Biology. 1(1):13
Appel, B. (2000) Zebrafish neural induction and patterning. Developmental Dynamics : an official publication of the American Association of Anatomists. 219(2):155-168
Appel, B., Fritz, A., Westerfield, M., Grunwald, D.J., Eisen, J.S., and Riley, B.B. (1999) Delta-mediated specification of midline cell fates in zebrafish embryos. Current biology : CB. 9:247-256
Appel, B. (1999) LIMitless combinations?. Neuron. 22:3-5
Appel, B. and Eisen, J.S. (1998) Regulation of neuronal specification in the zebrafish spinal cord by Delta function. Development (Cambridge, England). 125:371-380
Moens, C.B., Yan, Y.L., Appel, B., Force, A.G., and Kimmel, C.B. (1996) valentino, a zebrafish gene required for normal hindbrain segmentation. Development (Cambridge, England). 122:3981-3990
Appel, B., Korzh, V., Glasgow, E., Thor, S., Edlund, T., Dawid, I.B., and Eisen, J.S. (1995) Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish. Development (Cambridge, England). 121:4117-4125