ZFIN ID: ZDB-PUB-001026-3
Zebrafish neural induction and patterning
Appel, B.
Date: 2000
Source: Developmental dynamics : an official publication of the American Association of Anatomists   219(2): 155-168 (Review)
Registered Authors: Appel, Bruce
Keywords: neural development; model systems; pattern formation; fate mapping; central nervous system; brain; spinal cord; organizer; anteroposterior axis; dorsoventral axis; Bmp; Nodal; Shh; Wnt; Notch
MeSH Terms:
  • Animals
  • Body Patterning*
  • Brain/embryology
  • Embryo, Nonmammalian/physiology
  • Nervous System/embryology*
  • Spinal Cord/embryology
  • Zebrafish/embryology*
PubMed: 11002336 Full text @ Dev. Dyn.
Formation of a functional nervous system requires that distinct types of cells develop at quite precise times and places. A goal of developmental neurobiologists is to understand the nature of the patterning mechanisms that specify neural cells for particular fates. In recent years, zebrafish has emerged as new model system for investigating vertebrate neural development, offering a unique combination of genetic, cellular, and molecular tools. Studies using zebrafish provide important new insights concerning the source and nature of molecular signals that induce and pattern the central nervous system.