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ZFIN ID: ZDB-PERS-960805-25
Allende, Miguel L.
Email: mallende@uchile.cl
URL: http://www.zebrafish.cl
Affiliation: Allende Lab
Address: Center for Genome Regulation Facultad de Ciencias Universidad de Chile Casilla 653 Santiago, Chile
Country: Chile
Phone: 56-2-2978-7390
Fax: 56-2-2276-3802
Orcid ID:

Degree in Biology, Universidad Católica de Chile, 1987
PhD in Molecular Biology, University of Pennsylvania, 1994
Postdoc in Developmental Genetics, MIT, 1994-1997
Assistant Professor, Universidad de Chile, 1998-2005
Associate Professor, Universidad de Chile, 2005-2009
Full Professor, Universidad de Chile, 2010-
Director, Millennium Nucleus in Developmental Biology, 1999-2006
Director, Millennium Nucleus 'Center for Genomics of the Cell', 2007-2010.
Director, Center for Genome Regulation, 2010-2020.

Young, R.M., Hawkins, T.A., Cavodeassi, F., Stickney, H.L., Schwarz, Q., Lawrence, L.M., Wierzbicki, C., Cheng, B.Y., Luo, J., Ambrosio, E.M., Klosner, A., Sealy, I.M., Rowell, J., Trivedi, C.A., Bianco, I.H., Allende, M.L., Busch-Nentwich, E.M., Gestri, G., Wilson, S.W. (2019) Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification. eLIFE. 8:
Morales, R.A., Allende, M.L. (2019) Peripheral Macrophages Promote Tissue Regeneration in Zebrafish by Fine-Tuning the Inflammatory Response. Frontiers in immunology. 10:253
Paredes-Zúñiga, S., Trost, N., De la Paz, J.F., Alcayaga, J., Allende, M.L. (2018) Behavioral effects of triadimefon in zebrafish are associated with alterations of the dopaminergic and serotonergic pathways. Progress in neuro-psychopharmacology & biological psychiatry. 92:118-126
Parada-Kusz, M., Penaranda, C., Hagedorn, E.J., Clatworthy, A., Nair, A.V., Henninger, J.E., Ernst, C., Li, B., Riquelme, R., Jijon, H., Villablanca, E.J., Zon, L.I., Hung, D., Allende, M.L. (2018) Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Disease models & mechanisms. 11(11):
Alvarez, M., Chávez, M.N., Miranda, M., Aedo, G., Allende, M.L., Egaña, J.T. (2018) A Novel In Vivo Model to Study Impaired Tissue Regeneration Mediated by Cigarette Smoke. Scientific Reports. 8:10926
Pouchucq, L., Undurraga, C.A., Fuentes, R., Cornejo, M., Allende, M.L., Monasterio, O. (2018) γ-Tubulin small complex formation is essential for early zebrafish embryogenesis. Mechanisms of Development. 154:145-152
Awan, B., Turkov, D., Schumacher, C., Jacobo, A., McEnerney, A., Ramsey, A., Xu, G., Park, D., Kalomoiris, S., Yao, W., Jao, L.E., Allende, M.L., Lebrilla, C.B., Fierro, F.A. (2018) FGF2 Induces Migration of Human Bone Marrow Stromal Cells by Increasing Core Fucosylations on N-Glycans of Integrins. Stem Cell Reports. 11(2):325-333
Marcoleta, A.E., Varas, M.A., Ortiz-Severín, J., Vásquez, L., Berríos-Pastén, C., Sabag, A.V., Chávez, F.P., Allende, M.L., Santiviago, C.A., Monasterio, O., Lagos, R. (2018) Evaluating Different Virulence Traits of Klebsiella pneumoniae Using Dictyostelium discoideum and Zebrafish Larvae as Host Models.. Frontiers in cellular and infection microbiology. 8:30
Díaz-Pascual, F., Ortíz-Severín, J., Varas, M.A., Allende, M.L., Chávez, F.P. (2017) In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae.. Frontiers in cellular and infection microbiology. 7:334
Varas, M., Ortíz-Severín, J., Marcoleta, A.E., Díaz-Pascual, F., Allende, M.L., Santiviago, C.A., Chávez, F.P. (2017) Salmonella Typhimurium induces cloacitis-like symptoms in zebrafish larvae. Microbial pathogenesis. 107:317-320
Paredes-Zúñiga, S., Morales, R.A., Muñoz-Sánchez, S., Muñoz-Montecinos, C., Parada, M., Tapia, K., Rubilar, C., Allende, M.L., Peña, O.A. (2017) CXCL12a/CXCR4b acts to retain neutrophils in caudal hematopoietic tissue and to antagonize recruitment to an injury site in the zebrafish larva. Immunogenetics. 69(5):341-349
De la Paz, J.F., Beiza, N., Paredes-Zúñiga, S., Hoare, M.S., Allende, M.L. (2017) Triazole Fungicides Inhibit Zebrafish Hatching by Blocking the Secretory Function of Hatching Gland Cells. International Journal of Molecular Sciences. 18(4):710
Varas, M., Fariña, A., Díaz-Pascual, F., Ortíz-Severín, J., Marcoleta, A.E., Allende, M.L., Santiviago, C.A., Chávez, F.P. (2017) Live-cell imaging of Salmonella Typhimurium interaction with zebrafish larvae after injection and immersion delivery methods. Journal of Microbiological Methods. 135:20-25
Pei, W., Huang, S.C., Xu, L., Pettie, K., Ceci, M.L., Sánchez, M., Allende, M.L., Burgess, S.M. (2016) Loss of Mgat5a-mediated N-glycosylation stimulates regeneration in zebrafish.. Cell regeneration (London, England). 5:3
Carrillo, S.A., Anguita-Salinas, C., Peña, O.A., Morales, R.A., Muñoz-Sánchez, S., Muñoz-Montecinos, C., Paredes-Zúñiga, S., Tapia, K., Allende, M.L. (2016) Macrophage Recruitment Contributes to Regeneration of Mechanosensory Hair Cells in the Zebrafish Lateral Line. Journal of cellular biochemistry. 117(8):1880-9
Sánchez, M., Ceci, M.L., Gutiérrez, D., Anguita-Salinas, C., Allende, M.L. (2016) Mechanosensory organ regeneration in zebrafish depends on a population of multipotent progenitor cells kept latent by Schwann cells. BMC Biology. 14:27
Chávez, M.N., Aedo, G., Fierro, F.A., Allende, M.L., Egaña, J.T. (2016) Zebrafish as an Emerging Model Organism to Study Angiogenesis in Development and Regeneration. Frontiers in Physiology. 7:56
Chávez, M.N., Schenck, T.L., Hopfner, U., Centeno-Cerdas, C., Somlai-Schweiger, I., Schwarz, C., Machens, H.G., Heikenwalder, M., Bono, M.R., Allende, M.L., Nickelsen, J., Egaña, J.T. (2016) Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration. Biomaterials. 75:25-36
Schenck, T.L., Hopfner, U., Chávez, M.N., Machens, H.G., Somlai-Schweiger, I., Giunta, R.E., Bohne, A.V., Nickelsen, J., Allende, M.L., Egaña, J.T. (2015) Photosynthetic biomaterials: a pathway towards autotrophic tissue engineering. Acta biomaterialia. 15:39-47
Lange, S., Gonzalez, I., Pinto, M.P., Arce, M., Valenzuela, R., Aranda, E., Elliot, M., Alvarez, M., Henriquez, S., Velasquez, E.V., Orge, F., Oliva, B., Gonzalez, P., Villalon, M., Cautivo, K.M., Kalergis, A.M., Pereira, K., Mendoza, C., Saez, C., Kato, S., Cuello, M.A., Parborell, F., Irusta, G., Palma, V., Allende, M.L., Owen, G.I. (2014) Independent Anti-Angiogenic Capacities of Coagulation Factors X and Xa. Journal of Cellular Physiology. 229(11):1673-80
Ceci, M.L., Mardones-Krsulovic, C., Sánchez, M., Valdivia, L.E., Allende, M.L. (2014) Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae. Neural Development. 9:22
Moya-Díaz, J., Peña, O.A., Sánchez, M., Ureta, D.A., Reynaert, N.G., Anguita-Salinas, C., Marín, G., and Allende, M.L. (2014) Electroablation: a method for neurectomy and localized tissue injury. BMC Developmental Biology. 14:7
Armas, P., Margarit, E., Mouguelar, V.S., Allende, M.L., and Calcaterra, N.B. (2013) Beyond the Binding Site: In Vivo Identification of tbx2, smarca5 and wnt5b as Molecular Targets of CNBP during Embryonic Development. PLoS One. 8(5):e63234
Quezada, M., Alvarez, M., Peña, O.A., Henríquez, S., Alençon, C.A., Lange, S., Oliva, B., Owen, G.I., and Allende, M.L. (2013) Antiangiogenic, antimigratory and antiinflammatory effects of 2-methoxyestradiol in zebrafish larvae. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 157(2):141-149
Villegas, R., Martin, S.M., O'Donnell, K., Carrillo, S., Sagasti, A., and Allende, M.L. (2012) Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types. Neural Development. 7(1):19
Valdivia, L.E., Young, R.M., Hawkins, T.A., Stickney, H.L., Cavodeassi, F., Schwarz, Q., Pullin, L.M., Villegas, R., Moro, E., Argenton, F., Allende, M.L., and Wilson, S.W. (2011) Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development. Development (Cambridge, England). 138(18):3931-3941
Allende, M.L., Calcaterra, N.B., Vianna, M.R., and Zolessi, F.R. (2011) First Meeting of the Latin American Zebrafish Network. Zebrafish.
Hernandez, P.P., Undurraga, C., Gallardo, V.E., Mackenzie, N., Allende, M.L., and Reyes, A.E. (2011) Sublethal concentrations of waterborne copper induce cellular stress and cell death in zebrafish embryos and larvae. Biological research. 44(1):7-15
d'Alencon, C.A., Pena, O.A., Wittmann, C., Gallardo, V.E., Jones, R.A., Loosli, F., Liebel, U., Grabher, C., and Allende, M.L. (2010) A high-throughput chemically induced inflammation assay in zebrafish. BMC Biology. 8:151
Gallardo, V.E., Liang, J., Behra, M., Elkahloun, A., Villablanca, E.J., Russo, V., Allende, M.L., and Burgess, S.M. (2010) Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish. BMC Developmental Biology. 10:120
Weiner, A.M., Allende, M.L., and Calcaterra, N.B. (2009) Zebrafish cnbp intron1 plays a fundamental role in controlling spatiotemporal gene expression during embryonic development. Journal of cellular biochemistry. 108(6):1364-1375
Pistocchi, A., Feijoo, C.G., Cabrera, P., Villablanca, E.J., Allende, M.L., and Cotelli, F. (2009) The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line. BMC Developmental Biology. 9:58
Feijoo, C.G., Sarrazin, A.F., Allende, M.L., and Glavic, A. (2009) Cystein-serine-rich nuclear protein 1, Axud1/Csrnp1, is essential for cephalic neural progenitor proliferation and survival in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 238(8):2034-2043
Nuñez, V.A., Sarrazin, A.F., Cubedo, N., Allende, M.L., Dambly-Chaudière, C., and Ghysen, A. (2009) Postembryonic development of the posterior lateral line in the zebrafish. Evolution & development. 11(4):391-404
Behra, M., Bradsher, J., Sougrat, R., Gallardo, V., Allende, M.L., and Burgess, S.M. (2009) Phoenix is required for mechanosensory hair cell regeneration in the zebrafish lateral line. PLoS Genetics. 5(4):e1000455
Feijoo, C.G., Saldias, M.P., De la Paz, J.F., Gómez-Skarmeta, J.L., and Allende, M.L. (2009) Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a. Molecular and cellular neurosciences. 40(3):328-337
Olivari, F.A., Hernández, P.P., and Allende, M.L. (2008) Acute copper exposure induces oxidative stress and cell death in lateral line hair cells of zebrafish larvae. Brain research. 1244:1-12
Hernández, P.P., and Allende, M.L. (2008) Zebrafish (Danio rerio) as a model for studying the genetic basis of copper toxicity, deficiency, and metabolism. The American journal of clinical nutrition. 88(3):835S-839S
Bergeron, S.A., Milla, L.A., Villegas, R., Shen, M.C., Burgess, S.M., Allende, M.L., Karlstrom, R.O., and Palma, V. (2008) Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos. Genomics. 91(2):165-177
Weiner, A.M., Allende, M.L., Becker, T.S., and Calcaterra, N.B. (2007) CNBP mediates neural crest cell expansion by controlling cell proliferation and cell survival during rostral head development. Journal of cellular biochemistry. 102(6):1553-1570
Blanco, M.J., Barrallo-Gimeno, A., Acloque, H., Reyes, A.E., Tada, M., Allende, M.L., Mayor, R., and Nieto, M.A. (2007) Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development (Cambridge, England). 134(22):4073-4081
Villablanca, E.J., Pistocchi, A., Court, F.A., Cotelli, F., Bordignon, C., Allende, M.L., Traversari, C., and Russo, V. (2007) Abrogation of Prostaglandin E2/EP4 Signaling Impairs the Development of rag1+ Lymphoid Precursors in the Thymus of Zebrafish Embryos. Journal of immunology (Baltimore, Md. : 1950). 179(1):357-364
Hernandez, P.P., Olivari, F.A., Sarrazin, A.F., Sandoval, P.C., and Allende, M.L. (2007) Regeneration in zebrafish lateral line neuromasts: Expression of the neural progenitor cell marker sox2 and proliferation-dependent and-independent mechanisms of hair cell renewal. Developmental Neurobiology. 67(5):637-654
Rojas, D.A., Perez-Munizaga, D.A., Centanin, L., Antonelli, M., Wappner, P., Allende, M.L., and Reyes, A.E. (2007) Cloning of hif-1alpha and hif-2alpha and mRNA expression pattern during development in zebrafish. Gene expression patterns : GEP. 7(3):339-345
Sarrazin, A.F., Villablanca, E.J., Nunez, V.A., Sandoval, P.C., Ghysen, A., and Allende, M.L. (2006) Proneural gene requirement for hair cell differentiation in the zebrafish lateral line. Developmental Biology. 295(2):534-545
Cerda, G.A., Thomas, J.E., Allende, M.L., Karlstrom, R.O., and Palma, V. (2006) Electroporation of DNA, RNA, and morpholinos into zebrafish embryos. Methods (San Diego, Calif.). 39(3):207-211
Allende, M.L., Manzanares, M., Tena, J.J., Feijoo, C.G., and Gomez-Skarmeta, J.L. (2006) Cracking the genome's second code: Enhancer detection by combined phylogenetic footprinting and transgenic fish and frog embryos. Methods (San Diego, Calif.). 39(3):212-219
Villablanca, E.J., Renucci, A., Sapede, D., Lec, V., Soubiran, F., Sandoval, P.C., Dambly-Chaudiere, C., Ghysen, A., and Allende, M.L. (2006) Control of cell migration in the zebrafish lateral line: Implication of the gene "Tumour-Associated Calcium Signal Transducer," tacstd. Developmental dynamics : an official publication of the American Association of Anatomists. 235(6):1578-1588
Hernandez, P.P., Moreno, V., Olivari, F.A., and Allende, M.L. (2006) Sub-lethal concentrations of waterborne copper are toxic to lateral line neuromasts in zebrafish (Danio rerio). Hearing Research. 213(1-2):1-10
de la Calle-Mustienes, E., Feijoo, C.G., Manzanares, M., Tena, J.J., Rodriguez-Seguel, E., Leticia, A., Allende, M.L., and Gomez-Skarmeta, J.L. (2005) A functional survey of the enhancer activity of conserved non-coding sequences from vertebrate Iroquois cluster gene deserts. Genome research. 15(8):1061-1072
Cavodeassi, F., Carreira-Barbosa, F., Young, R., Concha, M., Allende, M.L., Houart, C., Tada, M., and Wilson, S. (2005) Early Stages of Zebrafish Eye Formation Require the Coordinated Activity of Wnt11, Fz5, and the Wnt/Catenin Pathway. Neuron. 47(1):43-56
Armas, P., Cachero, S., Lombardo, V.A., Weiner, A., Allende, M.L., and Calcaterra, N.B. (2004) Zebrafish cellular nucleic acid-binding protein: gene structure and developmental behaviour. Gene. 337:151-161
Glavic, A., Maris Honoré, S., Gloria Feijóo, C., Bastidas, F., Allende, M.L., and Mayor, R. (2004) Role of BMP signaling and the homeoprotein iroquois in the specification of the cranial placodal field. Developmental Biology. 272(1):89-103
Feijoo, C.G., Manzanares, M., De La Calle-Mustienes, E., Gómez-Skarmeta, J.L., and Allende, M.L. (2004) The Irx gene family in zebrafish: genomic structure, evolution and initial characterization of irx5b. Development genes and evolution. 214(6):277-284
Mackenzie, N.C., Brito, M., Reyes, A.E., and Allende, M.L. (2004) Cloning, expression pattern and essentiality of the high-affinity copper transporter 1 (ctr1) gene in zebrafish. Gene. 328:113-120
O'Brien, E.K., d'Alencon, C., Bonde, G., Li, W., Schoenebeck, J., Allende, M.L., Gelb, B.D., Yelon, D., Eisen, J.S., and Cornell, R.A. (2004) Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. Developmental Biology. 265(1):246-261
Young, R., Reyes, A., and Allende, M. (2002) Expression and splice variant analysis of the zebrafish tcf4 transcription factor. Mechanisms of Development. 117(1-2):269-273
Young, R.M., Marty, S., Nakano, Y., Wang, H., Yamamoto, D., Lin, S., and Allende, M.L. (2002) Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 223(2):298-305
Semino, C.E. and Allende, M.L. (2000) Chitin oligosaccharides as candidate patterning agents in zebrafish embryogenesis. The International journal of developmental biology. 44(2):183-193
Becker, T.S., Burgess, S.M., Amsterdam, A.H., Allende, M.L., and Hopkins, N. (1998) not really finished is crucial for development of the zebrafish outer retina and encodes a transcription factor highly homologous to human Nuclear Respiratory Factor-1 and avian Initiation Binding Repressor. Development (Cambridge, England). 125:4369-4378
Semino, C.E., Allende, M.L., Bakkers, J., Sapink, H.P., and Robbins, P.P. (1998) Expression of Rhizobium Chitin Oligosaccharide Fucosyltransferase in zebrafish embryos disrupts normal development. Annals of the New York Academy of Sciences. 842:49-54
Ekker, M., Akimenko, M.-A., Allende, M.L., Smith, R., Drouin, G., Langille, R.M., Weinberg, E.S., and Westerfield, M. (1997) Relationships among msx gene structure and function in zebrafish and other vertebrates. Mol. Biol. Evol.. 14:1008-1022
Amsterdam, A., Yoon, C., Allende, M., Becker, T., Kawakami, K., Burgess, S., Gaiano, N., and Hopkins, N. (1997) Retrovirus-mediated insertional mutagenesis in zebrafish and identification of a molecular marker for embryonic germ cells. Cold Spring Harbor symposia on quantitative biology. 62:437-450
Allende, M.L., Amsterdam, A., Becker, T., Kawakami, K., Gaiano, N., and Hopkins, N. (1996) Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development. Genes & Development. 10(24):3141-3155
van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki-, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development (Cambridge, England). 123:153-164
Odenthal, J., Haffter, P., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting the formation of the notochord in the zebrafish, Danio rerio. Development (Cambridge, England). 123:103-115
Gaiano, N., Amsterdam, A., Kawakami, K., Allende, M., Becker, T., and Hopkins, N. (1996) Insertional mutagenesis and rapid cloning of essential genes in zebrafish. Nature. 383(6603):829-832
Gaiano, N., Allende, M., Amsterdam, A., Kawakami, K., and Hopkins, N. (1996) Highly efficient germ-line transmission of proviral insertions in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 93(15):7777-7782
Weinberg, E.S., Allende, M.L., Kelly, C.S., Abdelhamid, A., Murakami, T., Andermann, P., Doerre, O.G., Grunwald, D.J., and Riggleman, B. (1996) Developmental regulation of zebrafish MyoD in wild-type, no-tail and spadetail embryos. Development (Cambridge, England). 122:271-280
Li, Y., Allende, M.L., Finkelstein, R., and Weinberg, E.S. (1994) Expression of two zebrafish orthodenticle-related genes in the embryonic brain. Mechanisms of Development. 48(3):229-244
Allende, M.L. and Weinberg, E.S. (1994) The expression pattern of two zebrafish achaete-scute homolog (ash) genes is altered in the embryonic brain of the cyclops mutant. Developmental Biology. 166:509-530
Daniotti, J.L., Allende, M.L., Weinberg, E.S., and Allende, J.E. (1994) Cloning and expression of genes coding for protein kinase CK2 alpha and beta subunits in zebrafish (Danio rerio). Cellular & molecular biology research. 40:431-439
Allende, M.L. (1994) Characterization and embryonic expression of two zebrafish Achaete-Scute homolog genes. Ph.D. Thesis.

Vidal EA, Moyano TC, Bustos BI, Pérez-Palma E, Moraga C, Riveras E, Montecinos A, Azócar L, Soto DC, Vidal M, Di Genova A, Puschel K, Nürnberg P, Buch S, Hampe J, Allende ML, Cambiazo V, González M, Hodar C, Montecino M, Muñoz-Espinoza C, Orellana A, Reyes-Jara A, Travisany D, Vizoso P, Moraga M, Eyheramendy S, Maass A, De Ferrari GV, Miquel JF, Gutiérrez RA. (2019) Whole Genome Sequence, Variant Discovery and Annotation in Mapuche-Huilliche Native South Americans. Sci Rep. 9(1):2132.

Rojas A, Sepulveda H, Henriquez B, Aguilar R, Opazo T, Nardocci G, Bustos F, Lian JB, Stein JL, Stein GS, van Zundert B, van Wijnen AJ, Allende ML, Montecino M. (2019) Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts. J Cell Physiol. 234(5):6244-6253.