ZFIN ID: ZDB-PUB-060323-33
Control of cell migration in the zebrafish lateral line: Implication of the gene "Tumour-Associated Calcium Signal Transducer," tacstd
Villablanca, E.J., Renucci, A., Sapede, D., Lec, V., Soubiran, F., Sandoval, P.C., Dambly-Chaudiere, C., Ghysen, A., and Allende, M.L.
Date: 2006
Source: Developmental dynamics : an official publication of the American Association of Anatomists   235(6): 1578-1588 (Journal)
Registered Authors: Allende, Miguel L., Ghysen, Alain, Renucci, Armand, Sapede, Dora, Soubiran, Fabien
Keywords: lateral line, morpholino, 4-Di-2-ASP, cell migration, EpCAM, trop2
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Antigens, Neoplasm/genetics
  • Calcium Signaling/genetics*
  • Calcium Signaling/physiology
  • Cell Adhesion Molecules/genetics
  • Cell Movement/genetics*
  • Cell Movement/physiology
  • Humans
  • Membrane Glycoproteins/genetics*
  • Membrane Glycoproteins/metabolism
  • Molecular Sequence Data
  • Zebrafish/embryology*
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
  • Zebrafish Proteins/physiology
PubMed: 16552761 Full text @ Dev. Dyn.
The sensory organs of the zebrafish lateral-line system (neuromasts) originate from migrating primordia that move along precise pathways. The posterior primordium, which deposits the neuromasts on the body and tail of the embryo, migrates along the horizontal myoseptum from the otic region to the tip of the tail. This migration is controlled by the chemokine SDF1, which is expressed along the prospective pathway, and by its receptor CXCR4, which is expressed by the migrating cells. In this report, we describe another zebrafish gene that is heterogeneously expressed in the migrating cells, tacstd. This gene codes for a membrane protein that is homologous to the TACSTD1/2 mammalian proteins. Inactivation of the zebrafish tacstd gene results in a decrease in proneuromast deposition, suggesting that tacstd is required for the deposition process.