PUBLICATION
Knockdown of tgfb1a partially improves ALS phenotype in a transient zebrafish model
- Authors
- Gonzalez, D., Cuenca, X., Allende, M.L.
- ID
- ZDB-PUB-240422-6
- Date
- 2024
- Source
- Frontiers in Cellular Neuroscience 18: 13840851384085 (Journal)
- Registered Authors
- Allende, Miguel L.
- Keywords
- amyotrophic lateral sclerosis, danio rerio, motor neuron, neurodegenerative disease, transforming growth factor type β, zebrafish
- MeSH Terms
- none
- PubMed
- 38644973 Full text @ Front. Cell. Neurosci.
Citation
Gonzalez, D., Cuenca, X., Allende, M.L. (2024) Knockdown of tgfb1a partially improves ALS phenotype in a transient zebrafish model. Frontiers in Cellular Neuroscience. 18:13840851384085.
Abstract
Amyotrophic lateral sclerosis (ALS) corresponds to a neurodegenerative disorder marked by the progressive degeneration of both upper and lower motor neurons located in the brain, brainstem, and spinal cord. ALS can be broadly categorized into two main types: sporadic ALS (sALS), which constitutes approximately 90% of all cases, and familial ALS (fALS), which represents the remaining 10% of cases. Transforming growth factor type-β (TGF-β) is a cytokine involved in various cellular processes and pathological contexts, including inflammation and fibrosis. Elevated levels of TGF-β have been observed in the plasma and cerebrospinal fluid (CSF) of both ALS patients and mouse models. In this perspective, we explore the impact of the TGF-β signaling pathway using a transient zebrafish model for ALS. Our findings reveal that the knockdown of tgfb1a lead to a partial prevention of motor axon abnormalities and locomotor deficits in a transient ALS zebrafish model at 48 h post-fertilization (hpf). In this context, we delve into the proposed distinct roles of TGF-β in the progression of ALS. Indeed, some evidence suggests a dual role for TGF-β in ALS progression. Initially, it seems to exert a neuroprotective effect in the early stages, but paradoxically, it may contribute to disease progression in later stages. Consequently, we suggest that the TGF-β signaling pathway emerges as an attractive therapeutic target for treating ALS. Nevertheless, further research is crucial to comprehensively understand the nuanced role of TGF-β in the pathological context.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping