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ZIRC
ZFIN ID: ZDB-MRPHLNO-060815-1
Morpholino Name: MO1-cdh2
Target: cdh2 (2)
Previous Names: N-cad MO (1), ncad-MO1 (1)

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Sequence:
5' - TCTGTATAAAGAAACCGATAGAGTT - 3'
   
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  (Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.)
TARGET LOCATION
No data available
CONSTRUCTS WITH SEQUENCES FROM MO1-cdh2 No data available
GENE EXPRESSION
Gene expression in Wild Types + MO1-cdh2
Expressed Gene Anatomy Figures
cdh2 Fig. S5 with image from Harrington et al., 2007
gli1 Fig. 4 from Chalasani et al., 2011
gli2a Fig. 4 from Chalasani et al., 2011
otx2b Fig. S2 with image from von der Hardt et al., 2007
otx5 Fig. 4 with image from Aquilina-Beck et al., 2007
ptch2 Fig. 4 from Chalasani et al., 2011
shhb Fig. 4 from Chalasani et al., 2011
six3b Fig. 6 with image from von der Hardt et al., 2007
sox3 Fig. S1 with image from Harrington et al., 2007
szl Fig. 6 with imageFig. S2 with image from von der Hardt et al., 2007
tbxta Fig. 5 with image from Yang et al., 2011
PHENOTYPE
Phenotype resulting from MO1-cdh2
Phenotype Figures
branchiomotor neuron decreased cellular motility, abnormal Fig. 6 with imageFig. 7 with imageFig. 8 with image from Wanner et al., 2013
branchiomotor neuron detached from medial longitudinal fasciculus, abnormal Fig. 8 with image from Wanner et al., 2013
branchiomotor neuron neuron migration decreased velocity, abnormal Fig. 6 with imageFig. 7 with imageFig. 8 with image from Wanner et al., 2013
epiphysis split, abnormal Fig. 4 with image from Aquilina-Beck et al., 2007
fourth ventricle increased size, abnormal Fig. 3 with image from Lele et al., 2002
hindbrain disorganized, abnormal Fig. 3 with image from Lele et al., 2002
hindbrain neural tube ptch2 expression increased distribution, abnormal Fig. 4 from Chalasani et al., 2011
hindbrain neural tube gli2a expression increased distribution, abnormal Fig. 4 from Chalasani et al., 2011
hindbrain neural tube gli1 expression increased distribution, abnormal Fig. 4 from Chalasani et al., 2011
intersegmental vessel malformed, abnormal Fig. 6 from Agarwal et al., 2014
midbrain disorganized, abnormal Fig. 3 with image from Lele et al., 2002
neuroepithelial cell displaced to fourth ventricle, abnormal Fig. 3 with image from Lele et al., 2002
neuron cell-cell adhesion disrupted, abnormal Fig. 7 with imageFig. 8 with image from Wanner et al., 2013
posterior lateral line neuromast decreased amount, abnormal Fig. 3 from Xing et al., 2015
posterior lateral line neuromast far from posterior lateral line neuromast, abnormal Fig. 3 from Xing et al., 2015
posterior neural tube T-shaped, abnormal Fig. S1 with image from Harrington et al., 2007
smoothened signaling pathway increased process quality, abnormal Fig. 4 from Chalasani et al., 2011
whole organism morphology, abnormal Fig. 4 with image from Warga et al., 2007

Phenotype of all Fish created by or utilizing MO1-cdh2
Phenotype Fish Conditions Figures
whole organism morphology, abnormal cdh2tb8/tb8 + MO1-cdh2 standard conditions Fig. 4 with image from Warga et al., 2007
hindbrain neural tube gli2a expression increased distribution, abnormal TL + MO1-cdh2 standard conditions Fig. 4 from Chalasani et al., 2011
hindbrain neural tube gli1 expression increased distribution, abnormal TL + MO1-cdh2 standard conditions Fig. 4 from Chalasani et al., 2011
smoothened signaling pathway increased process quality, abnormal TL + MO1-cdh2 standard conditions Fig. 4 from Chalasani et al., 2011
hindbrain neural tube ptch2 expression increased distribution, abnormal TL + MO1-cdh2 standard conditions Fig. 4 from Chalasani et al., 2011
posterior neural tube T-shaped, abnormal WT + MO1-cdh2 standard conditions Fig. S1 with image from Harrington et al., 2007
epiphysis split, abnormal WT + MO1-cdh2 standard conditions Fig. 4 with image from Aquilina-Beck et al., 2007
neuroepithelial cell displaced to fourth ventricle, abnormal WT + MO1-cdh2 standard conditions Fig. 3 with image from Lele et al., 2002
hindbrain disorganized, abnormal WT + MO1-cdh2 standard conditions Fig. 3 with image from Lele et al., 2002
midbrain disorganized, abnormal WT + MO1-cdh2 standard conditions Fig. 3 with image from Lele et al., 2002
fourth ventricle increased size, abnormal WT + MO1-cdh2 standard conditions Fig. 3 with image from Lele et al., 2002
pectoral fin bud cartilage element disorganized, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 4 with image from Liu et al., 2003
cranial nerve II defasciculated, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 3 with image from Liu et al., 2003
midbrain disorganized, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 3 with image from Liu et al., 2003
pectoral fin development disrupted, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 3 with imageFig. 4 with image from Liu et al., 2003
fourth ventricle cell mislocalised, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 3 with image from Liu et al., 2003
hair cell posterior macula kinocilium decreased length, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 1 from Babb-Clendenon et al., 2006
hindbrain disorganized, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 3 with image from Liu et al., 2003
semicircular canal aplastic, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 5 from Babb-Clendenon et al., 2006
hair cell anterior macula kinocilium decreased length, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 1 from Babb-Clendenon et al., 2006
pectoral fin bud cartilage element absent, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 4 with image from Liu et al., 2003
hair cell posterior macula stereocilium bundle decreased length, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 5 from Babb-Clendenon et al., 2006
fourth ventricle increased size, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 3 with image from Liu et al., 2003
midbrain fourth ventricle mislocalised anteriorly, abnormal WT + MO1-cdh2 + MO2-cdh2 standard conditions Fig. 3 with image from Liu et al., 2003
whole organism morphology, abnormal cdh2tb8/+ + MO1-cdh2 standard conditions Fig. 4 with image from Warga et al., 2007
branchiomotor neuron detached from medial longitudinal fasciculus, abnormal ch100Tg + MO1-cdh2 standard conditions Fig. 8 with image from Wanner et al., 2013
neuron cell-cell adhesion disrupted, abnormal ch100Tg + MO1-cdh2 standard conditions Fig. 7 with imageFig. 8 with image from Wanner et al., 2013
branchiomotor neuron decreased cellular motility, abnormal ch100Tg + MO1-cdh2 standard conditions Fig. 7 with imageFig. 8 with image from Wanner et al., 2013
branchiomotor neuron neuron migration decreased velocity, abnormal ch100Tg + MO1-cdh2 standard conditions Fig. 7 with imageFig. 8 with image from Wanner et al., 2013
posterior lateral line neuromast far from posterior lateral line neuromast, abnormal zf106Tg + MO1-cdh2 standard conditions Fig. 3 from Xing et al., 2015
posterior lateral line neuromast decreased amount, abnormal zf106Tg + MO1-cdh2 standard conditions Fig. 3 from Xing et al., 2015
branchiomotor neuron neuron migration decreased velocity, abnormal ch100Tg; knu3Tg + MO1-cdh2 standard conditions Fig. 6 with image from Wanner et al., 2013
branchiomotor neuron decreased cellular motility, abnormal ch100Tg; knu3Tg + MO1-cdh2 standard conditions Fig. 6 with image from Wanner et al., 2013
lens epithelium cell migration process quality, abnormal kca6Tg ; oki011Tg ; kca66Tg + MO1-cdh2 control Fig. 2Fig. 4 with image from Mochizuki et al., 2017
lens epithelium tension, abnormal kca6Tg ; oki011Tg ; kca66Tg + MO1-cdh2 light ablation: lens epithelium Fig. 5 with image from Mochizuki et al., 2017
lens epithelium cell migration process quality, abnormal kca6Tg ; oki011Tg ; kca66Tg + MO1-cdh2 light ablation: lens epithelium Fig. 5 with image from Mochizuki et al., 2017
intersegmental vessel malformed, abnormal sd2Tg; y1Tg + MO1-cdh2 chemical treatment: ligand Fig. 6 from Agarwal et al., 2014
intersegmental vessel malformed, abnormal sd2Tg; y1Tg + MO1-cdh2 standard conditions Fig. 6 from Agarwal et al., 2014
dorsal convergence disrupted, abnormal WT + MO1-cdh2 + MO1-chrd standard conditions Fig. 6 with image from von der Hardt et al., 2007
lateral mesoderm mislocalised, abnormal WT + MO1-cdh2 + MO1-chrd standard conditions Fig. 6 with image from von der Hardt et al., 2007
axis melanoblast mislocalised medially, abnormal WT + MO1-cdh2 + MO2-ovol1a standard conditions Fig. 4 with image from Piloto et al., 2010
whole organism has extra parts of type post-vent region, abnormal WT + MO1-cdh2 + MO2-tll1 standard conditions Fig. 5 with image from Yang et al., 2011
notochord morphogenesis disrupted, abnormal WT + MO1-cdh2 + MO2-tll1 standard conditions Fig. 5 with image from Yang et al., 2011
post-anal tail morphogenesis disrupted, abnormal WT + MO1-cdh2 + MO2-tll1 standard conditions Fig. 5 with image from Yang et al., 2011
post-vent region deformed, abnormal WT + MO1-cdh2 + MO2-tll1 standard conditions Fig. 5 with image from Yang et al., 2011
post-anal tail morphogenesis having extra processual parts post-anal tail morphogenesis, abnormal WT + MO1-cdh2 + MO2-tll1 standard conditions Fig. 5 with image from Yang et al., 2011
post-anal tail morphogenesis disrupted, abnormal WT + MO1-cdh2 + MO1-dvl2 + MO1-dvl3a standard conditions Fig. 5 with image from Yang et al., 2011
post-anal tail morphogenesis having extra processual parts post-anal tail morphogenesis, abnormal WT + MO1-cdh2 + MO1-dvl2 + MO1-dvl3a standard conditions Fig. 5 with image from Yang et al., 2011
whole organism has extra parts of type post-vent region, abnormal WT + MO1-cdh2 + MO1-dvl2 + MO1-dvl3a standard conditions Fig. 5 with image from Yang et al., 2011
post-vent region deformed, abnormal WT + MO1-cdh2 + MO1-dvl2 + MO1-dvl3a standard conditions Fig. 5 with image from Yang et al., 2011
neuroepithelial cell catenin complex spatial pattern, abnormal ctnna1ct3aGt + MO1-cdh2 standard conditions Fig. 3 with image from Zigman et al., 2011
secondary neural tube formation decreased process quality, abnormal ctnna1ct3aGt + MO1-cdh2 standard conditions Fig. 3 with image from Zigman et al., 2011
establishment of mitotic spindle orientation decreased process quality, abnormal ctnna1ct3aGt + MO1-cdh2 standard conditions Fig. 3 with image from Zigman et al., 2011
OTHER MO1-cdh2 MORPHOLINO PAGESNo links to external sites
CITATIONS (28)