Gene

tbxta

ID

ZDB-GENE-980526-437

Name

T-box transcription factor Ta

Symbol

tbxta Nomenclature History

Previous Names

T
ta
ZF-T (1)
zft
brachyury
cb240 (1)
id:ibd5074 (1)
no tail a
ntl
ntla
wu:fc80a01 (1)
ZF-NTL (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including convergent extension; notochord development; and regionalization. Located in nucleus. Part of chromatin. Is expressed in several structures, including blastoderm; germ ring; mesoderm; presumptive structure; and tail bud. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

548 figures from 382 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb240 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 52 figures from 35 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tbxta Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Sacral agenesis with vertebral anomalies	615709
		{Neural tube defects, susceptibility to}	182940

Associated With tbxta Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018186	Transcription factor, T-box, conserved site
Domain	IPR046360	T-box transcription factor, DNA-binding domain
Family	IPR001699	T-box transcription factor
Family	IPR002070	Transcription factor, Brachyury
Homologous_superfamily	IPR036960	T-box superfamily

Domain Details Per Protein

Protein	Length	T-box superfamily	T-box transcription factor	T-box transcription factor, DNA-binding domain	Transcription factor, Brachyury	Transcription factor, T-box, conserved site
UniProtKB:Q07998 InterPro	423

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	tbxta-201 (1) Ensembl	2211 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ta-002 (1) Ensembl	851 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Citations
Ab1-ta	polyclonal	tbxta		Rabbit	IHC	40
AB3-ta	monoclonal	tbxta	IgG1	Mouse		2
Ab2-ta	monoclonal	tbxta		Mouse		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations