ZFIN Gene: tbxta

ZFIN ID: ZDB-GENE-980526-437

ZFIN ID: ZDB-GENE-980526-437

Gene Name:

T-box transcription factor Ta

Gene Symbol:

tbxta

Sequence Ontology ID :

Previous Names:

T, ta, ZF-T (1), zft, brachyury, cb240 (1), id:ibd5074 (1), no tail a, ntl, ntla, wu:fc80a01 (1), ZF-NTL (1)

Location:

Chr: 19 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Exhibits sequence-specific DNA binding activity and transcription regulatory region DNA binding activity. Involved in several processes, including Kupffer's vesicle development; animal organ ...

GENE EXPRESSION
All Expression Data:	525 figures from 366 publications
Directly Submitted Expression Data:	7 figures (18 images) from Thisse et al., 2001 [cb240]
	1 figure (2 images) from Kudoh et al., 2001 [ibd5074]
Wild-type Stages, Structures:	Blastula:128-cell (2.25h-2.5h) to Adult (90d-730d, breeding adult)
	anatomical structure anterior axial hypoblast axial chorda mesoderm nucleus axial chorda mesoderm axial hypoblast posterior region axial hypoblast axial mesoderm nucleus axial mesoderm axis dorsal region axis blastoderm margin blastoderm blastodisc posterior margin blastodisc brain cell cell junction chordo neural hinge DEL embryonic structure epiblast nucleus epiblast EVL nucleus floor plate forerunner cell group germ ring hypoblast nucleus hypoblast Kupffer's vesicle margin marginal blastomere nucleus marginal blastomere mesoderm dorsal-most region mesoderm posterior region mesoderm neuroectoderm notochord cell notochord distal region notochord notochord posterior region post-vent region prechordal plate presumptive dorsal mesoderm presumptive mesoderm presumptive neural plate presumptive shield segmental plate shield tail bud dorsal region tail bud epiblast tail bud mesenchyme tail bud mesodermal cell tail bud presumptive mesoderm tail bud ventral region tail bud trunk unspecified whole organism dorsal region whole organism dorsal side whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
b160	Insertion	Unknown	Unknown	G_RAYS
b195	Insertion	Unknown	Unknown	SPONTANEOUS	Zebrafish International Resource Center (ZIRC) (order this)
b459	Unknown	Unknown	Unknown
b487	Unknown	Unknown	Unknown
kt338	Unknown	Unknown	Unknown
kt501a	Unknown	Unknown	Unknown
kt633	Unknown	Unknown	Unknown
m147	Unknown	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
m550	Unknown	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa13983	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
tb244e	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tbxta_unspecified	Unspecified	Unknown	Unknown
tc41	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
ts260	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
w181	Complex	Unknown	Unknown	SPONTANEOUS

Targeting reagents:

PHENOTYPE

Data:

51 figures from 34 publications

Observed in:

DISEASE ASSOCIATED WITH tbxta HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
	Sacral agenesis with vertebral anomalies	615709
	{Neural tube defects, susceptibility to}	182940

DISEASE ASSOCIATED WITH tbxta VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	convergent extension involved in axis elongation (more)
Cellular Component	nuclear chromatin (more)
Molecular Function	DNA binding (more)

GO Terms (all 41)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001699 (1) InterPro:IPR002070 (1) InterPro:IPR008967 (1) InterPro:IPR018186 (1) InterPro:IPR036960 (1)	PROSITE:PS01264 (1) PROSITE:PS01283 (1) PROSITE:PS50252 (1)	Pfam:PF00907 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	ta-002 (1)	851	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tbxta-201 (1)	2211	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIES

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM tbxta

MARKER RELATIONSHIPS

tbxta Contained in:	[BAC] CH73-285B23 (1) (order this)
tbxta Encodes:	[EST] cb240 (1), fc80a01 (1), ibd5074 (1) (order this) [cDNA] MGC:193897 (1) (order this), MGC:193903 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131162 (1)	2238 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU633985 (1)	108421 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q07998 (1)	423 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:1468 (1)

Sequence Information (all 24)

OTHER tbxta GENE PAGES

Alliance (1)

Gene:30399 (1)

VEGA:OTTDARG00000032979 (1)

Ensembl(GRCz11):ENSDARG00000101576 (1)

ORTHOLOGY for tbxta ( Chr: 19 )

CITATIONS (826)

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