ZFIN Gene: tbxta

ZFIN ID: ZDB-GENE-980526-437

ZFIN ID: ZDB-GENE-980526-437

Gene Name:

T-box transcription factor Ta

Gene Symbol:

tbxta Nomenclature History

Previous Names:

T, ta, ZF-T (1), zft, brachyury, cb240 (1), id:ibd5074 (1), no tail a, ntl, ntla, wu:fc80a01 (1), ZF-NTL (1)

Gene Type:

protein_coding_gene

Location:

Chr: 19 Mapping Details/Browsers

Description:

Exhibits sequence-specific DNA binding activity and transcription regulatory region DNA binding activity. Involved in several processes, including Kupffer's vesicle development; animal organ development; and regulation of embryonic development. Localizes to nuclear chromatin. Human ortholog(s) of this gene implicated in neural tube defect. Is expressed in several structures, including blastoderm; germ ring; mesoderm; presumptive structure; and tail bud. Orthologous to human TBXT (T-box transcription factor T).

Genome Resources:

Alliance (1), Gene:30399 (1), Ensembl(GRCz11):ENSDARG00000101576 (1)

GENE EXPRESSION
All Expression Data:	528 figures from 369 publications
Directly Submitted Expression Data:	7 figures (18 images) from Thisse et al., 2001 [cb240]
	1 figure (2 images) from Kudoh et al., 2001 [ibd5074]
Wild-type Stages, Structures:	Blastula:128-cell (2.25h-2.5h) to Adult (90d-730d, breeding adult)
	anatomical structure anterior axial hypoblast axial chorda mesoderm nucleus axial chorda mesoderm axial hypoblast posterior region axial hypoblast axial mesoderm nucleus axial mesoderm axis dorsal region axis blastoderm margin blastoderm blastodisc posterior margin blastodisc brain cell cell junction chordo neural hinge DEL embryonic structure epiblast nucleus epiblast EVL nucleus floor plate forerunner cell group germ ring hypoblast nucleus hypoblast Kupffer's vesicle margin marginal blastomere nucleus marginal blastomere mesoderm dorsal-most region mesoderm posterior region mesoderm neuroectoderm notochord cell notochord distal region notochord notochord posterior region post-vent region prechordal plate presumptive dorsal mesoderm presumptive mesoderm presumptive neural plate presumptive shield segmental plate shield tail bud dorsal region tail bud epiblast tail bud mesenchyme tail bud mesodermal cell tail bud presumptive mesoderm tail bud ventral region tail bud trunk unspecified whole organism dorsal region whole organism dorsal side whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
b160	Insertion	Unknown	Unknown	G_RAYS
b195	Insertion	Unknown	Unknown	SPONTANEOUS	Zebrafish International Resource Center (ZIRC) (order this)
b459	Unknown	Unknown	Unknown
b487	Unknown	Unknown	Unknown
kt338	Unknown	Unknown	Unknown
kt501a	Unknown	Unknown	Unknown
kt633	Unknown	Unknown	Unknown
m147	Unknown	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
m550	Unknown	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa13983	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
tb244e	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tbxta_unspecified	Unspecified	Unknown	Unknown
tc41	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
ts260	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
w181	Complex	Unknown	Unknown	SPONTANEOUS

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-tbxta		1
CRISPR2-tbxta		1
CRISPR3-tbxta		1
CRISPR4-tbxta		1
MO1-tbxta	N/A	30
MO2-tbxta	N/A	7
MO3-tbxta	N/A	14
MO4-tbxta	N/A	2
MO5-tbxta	N/A	2
TALEN1-tbxta		1
TALEN2-tbxta		1
TALEN3-tbxta		1
TALEN4-tbxta		1
TALEN5-tbxta		1
TALEN6-tbxta		1
TALEN7-tbxta		1

PHENOTYPE

Data:

51 figures from 34 publications

Observed in:

DISEASE ASSOCIATED WITH tbxta HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Sacral agenesis with vertebral anomalies	615709
		{Neural tube defects, susceptibility to}	182940

DISEASE ASSOCIATED WITH tbxta VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	convergent extension involved in axis elongation (more)
Cellular Component	nuclear chromatin (more)
Molecular Function	DNA binding (more)

GO Terms (all 41)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	tbxta-201 (1)	2211	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ta-002 (1)	851	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Publications
Ab1-ta	polyclonal		Rabbit	IHC	40
AB3-ta	monoclonal	IgG1	Mouse		2
Ab2-ta	monoclonal		Mouse		2

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM tbxta

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(-1tbxta:CFP)	tbxta	CFP	Danio rerio	1	3
Tg(HSE:ntla-MYC,EGFP)		EGFP, tbxta	Danio rerio	1	4
Tg(ntla:GAL4-VP16)	tbxta	GAL4, VP16	Danio rerio	1	3
Tg(tbxta:Kaede)	tbxta	Kaede	Danio rerio	1	1
Tg(tbxta:LY-Tomato)	tbxta	LY, Tomato	Danio rerio	1	3
tg(tbxta:mcherry-2a-cre)	tbxta	2A, Cre, mCherry	Danio rerio	1	1
TgBAC(tbxta:tbxta-FLAG)	tbxta	tbxta	Danio rerio	1	2

MARKER RELATIONSHIPS

tbxta Contained in:	[BAC] CH73-285B23 (1)
tbxta Encodes:	[EST] cb240 (1), fc80a01 (1), ibd5074 (1) [cDNA] MGC:193897 (1), MGC:193903 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131162 (1)	2238 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU633985 (1)	108421 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q07998 (1)	423 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 23)

ORTHOLOGY for tbxta ( Chr: 19 )

CITATIONS (836)

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