Gene

tbxta

ID
ZDB-GENE-980526-437
Name
T-box transcription factor Ta
Symbol
tbxta Nomenclature History
Previous Names
  • T
  • ta
  • ZF-T (1)
  • zft
  • brachyury
  • cb240 (1)
  • id:ibd5074 (1)
  • no tail a
  • ntl
  • ntla
  • wu:fc80a01 (1)
  • ZF-NTL (1)
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including Kupffer's vesicle development; animal organ development; and regulation of embryonic development. Localizes to nuclear chromatin. Is expressed in several structures, including blastoderm; germ ring; mesoderm; presumptive structure; and tail bud. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T).
Genome Resources
Note
None
Expression
All Expression Data
530 figures from 370 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
51 figures from 34 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbxta Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Sacral agenesis with vertebral anomalies 615709
{Neural tube defects, susceptibility to} 182940
Associated With tbxta Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Family IPR001699 Transcription factor, T-box
Family IPR002070 Transcription factor, Brachyury
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR036960 T-box superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding T-box superfamily Transcription factor, Brachyury Transcription factor, T-box Transcription factor, T-box, conserved site
UniProtKB:Q07998 423
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ta polyclonal Rabbit
  • IHC
40
AB3-ta monoclonal IgG1 Mouse
2
Ab2-ta monoclonal Mouse
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations