Gene

tbxta

ID

ZDB-GENE-980526-437

Name

T-box transcription factor Ta

Symbol

tbxta Nomenclature History

Previous Names

T
ta
ZF-T (1)
zft
brachyury
cb240 (1)
id:ibd5074 (1)
no tail a
ntl
ntla
wu:fc80a01 (1)
ZF-NTL (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including Kupffer's vesicle development; animal organ development; and regulation of embryonic development. Localizes to nuclear chromatin. Is expressed in several structures, including blastoderm; germ ring; mesoderm; presumptive structure; and tail bud. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T).

Genome Resources

Note

None

Expression

All Expression Data

530 figures from 370 publications

Cross-Species Comparison

High Throughput Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 51 figures from 34 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tbxta Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Sacral agenesis with vertebral anomalies	615709
		{Neural tube defects, susceptibility to}	182940

Associated With tbxta Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018186	Transcription factor, T-box, conserved site
Family	IPR001699	Transcription factor, T-box
Family	IPR002070	Transcription factor, Brachyury
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding
Homologous_superfamily	IPR036960	T-box superfamily

Domain Details Per Protein

Protein	Length	p53-like transcription factor, DNA-binding	T-box superfamily	Transcription factor, Brachyury	Transcription factor, T-box	Transcription factor, T-box, conserved site
UniProtKB:Q07998 InterPro	423

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	tbxta-201 (1) Ensembl	2211 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ta-002 (1) Ensembl	851 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Citations
Ab1-ta	polyclonal	tbxta		Rabbit	IHC	40
AB3-ta	monoclonal	tbxta	IgG1	Mouse		2
Ab2-ta	monoclonal	tbxta		Mouse		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Ensembl Gene Tree

Citations