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ZIRC
ZFIN ID: ZDB-GENE-030508-1
Gene Name: orthodenticle homolog 5
Gene Symbol: otx5    Nomenclature History

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Previous Name: cb828 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Involved in circadian regulation of gene expression and positive regulation of transcription, DNA-templated. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Is expressed in forebrain; optic vesicle; and visual system. Orthologous to human CRX (cone-rod homeobox).
Genome Resources: Alliance (1), Gene:353179 (1), Ensembl(GRCz11):ENSDARG00000043483 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-otx5 N/A 8
DISEASE ASSOCIATED WITH otx5 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cone-rod dystrophy 2 Alliance Cone-rod retinal dystrophy-2 120970
Leber congenital amaurosis 7 Alliance Leber congenital amaurosis 7 613829
DISEASE ASSOCIATED WITH otx5 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of transcription, DNA-templated (more)
Cellular Component nucleus (more)
Molecular Function sequence-specific DNA binding (more)
GO Terms (all 8)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA otx5-201 (1)    Ensembl 1747
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIESNo data available
PLASMIDSNo data available
CONSTRUCTS WITH SEQUENCES FROM otx5No data available
MARKER RELATIONSHIPS
otx5Contained in: [Fosmid] CH1073-111C8 (1) (order this)
otx5Encodes: [EST] cb828 (1) (order this)
[cDNA] MGC:65752 (1) (order this), MGC:76843 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_181331 (1) 1877bp
Genomic GenBank:CU633848 (1) 35813bp
Select Tool
Polypeptide UniProtKB:F1R982 (1) 289aa
Sequence Clusters UniGene:15426 (1)
Sequence Information (all 17)
ORTHOLOGY for otx5 (Chr: 15)
CITATIONS (86)