Gene

otx5

ID
ZDB-GENE-030508-1
Name
orthodenticle homolog 5
Symbol
otx5 Nomenclature History
Previous Names
  • cb828 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Involved in circadian regulation of gene expression and positive regulation of transcription, DNA-templated. Predicted to localize to nucleus. Is expressed in forebrain; optic vesicle; and visual system. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to human CRX (cone-rod homeobox).
Genome Resources
Note
None
Expression
All Expression Data
77 figures from 50 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With otx5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cone-rod dystrophy 2 Alliance Cone-rod retinal dystrophy-2 120970
Leber congenital amaurosis 7 Alliance Leber congenital amaurosis 7 613829
Associated With otx5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR013851 Transcription factor Otx, C-terminal
Family IPR003025 Transcription factor Otx
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Transcription factor Otx Transcription factor Otx, C-terminal
UniProtKB:Q6PH22 289
UniProtKB:Q6NYT9 289
UniProtKB:F1R982 289
UniProtKB:Q8UUZ5 289
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations