ZFIN ID: ZDB-GENE-980526-41
Gene Name: sonic hedgehog b
Gene Symbol: shhb
Previous Names: tiggy winkle hedgehog, twh, twhh
Location: Chr: 2   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 46 figures from 35 publications
Directly Submitted Expression Data: 7 figures (30 images) from Thisse et al., 2005 [eu390]
Wild-type Stages, Structures: Blastula:256-cell (2.5h-2.75h) to Adult (90d-730d, breeding adult)
  axis, diencephalon, endoderm, floor plate (all 23) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-shhb (1), MO2-shhb (1), MO3-shhb (1), MO4-shhb (1)

Allele Type Mutagen Suppliers
la023573Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028783Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in: blood circulation, odontogenesis, somite

    Phenotype of Human Orthologue OMIM Phenotype ID
    Holoprosencephaly-3 142945
    Microphthalmia with coloboma 5 611638
    Schizencephaly 269160
    Single median maxillary central incisor 147250
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic neurocranium morphogenesis (more)
    Cellular Component extracellular region (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000320 (1)
  • InterPro:IPR001657 (1)
  • InterPro:IPR001767 (1)
  • InterPro:IPR003586 (1)
  • InterPro:IPR003587 (1)
  • InterPro:IPR009045 (1)
  • InterPro:IPR028992 (1)
  • Pfam:PF01079 (1)
  • Pfam:PF01085 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA shhb-001 (1) 2019
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM shhb
    Et(shhb:GAL4TA4,UAS:mCherry), Et(shhb:KalTA4,UAS-E1b:mCherry), Tg(-5.2shhb:GFP), Tg(shhb:GAL4), Tg(shhb:GAL4TA4,5xUAS:mRFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    shhb Contained in: [BAC] DKEY-265A7 (1) (order this)
    shhb Encodes: [EST] eu390 (1)
    [cDNA] MGC:101003 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131199 (1) 1990 bp
    Genomic GenBank:BX510360 (1) 213323 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q6DBX7 (1) 416 aa
    Sequence Clusters UniGene:75752 (1)
    Sequence Information (all 18)
    OTHER shhb GENE PAGES
  • Gene:30444 (1)
  • VEGA:OTTDARG00000018411 (1)
  • Ensembl(Zv9):ENSDARG00000038867 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish shhb 2  
    Human SHH 7 (7q36)
  • OMIM:600725
  • Gene:6469
  • Mouse Shh 5 ( 14.39 cM)
  • MGI:98297
  • Gene:20423
  • Orthology Details
    CITATIONS (122)