ZFIN ID: ZDB-GENE-980526-41
Gene Name: sonic hedgehog b
Gene Symbol: shhb
Previous Names: tiggy winkle hedgehog, twh, twhh
Location: Chr: 2 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 47 figures from 36 publications
Directly Submitted Expression Data: 7 figures (30 images) from Thisse et al., 2005 [eu390]
Wild-type Stages, Structures: Blastula:256-cell (2.5h-2.75h) to Adult (90d-730d, breeding adult)
  axis, diencephalon, endoderm, floor plate (all 24) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023573Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028783Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-shhb (1), MO2-shhb (1), MO3-shhb (1), MO4-shhb (1)
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in: blood circulation, odontogenesis, somite
    DISEASE ASSOCIATED WITH shhb HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    holoprosencephaly Holoprosencephaly 3 142945
    Schizencephaly 269160
    Single median maxillary central incisor 147250
    Microphthalmia with coloboma 5 611638
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic neurocranium morphogenesis (more)
    Cellular Component extracellular region (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000320 (1)
  • InterPro:IPR001657 (1)
  • InterPro:IPR001767 (1)
  • InterPro:IPR003586 (1)
  • InterPro:IPR003587 (1)
  • InterPro:IPR009045 (1)
  • InterPro:IPR028992 (1)
  • Pfam:PF01079 (1)
  • Pfam:PF01085 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA shhb-001 (1) 2019
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM shhb
    Et(shhb:GAL4TA4,UAS:mCherry), Et(shhb:KALTA4,UAS-E1b:mCherry), Tg(-5.2shhb:GFP), Tg(shhb:GAL4), Tg(shhb:GAL4TA4,5xUAS:mRFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    shhbContained in: [BAC] DKEY-265A7 (1) (order this)
    shhbEncodes: [EST] eu390 (1)
    [cDNA] MGC:101003 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131199 (1) 1990bp
    Genomic GenBank:BX510360 (1) 213323bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0B5JJZ7 (1) 416aa
    Sequence Clusters UniGene:75752 (1)
    Sequence Information (all 21)
    OTHER shhb GENE PAGES
  • Gene:30444 (1)
  • VEGA:OTTDARG00000018411 (1)
  • Ensembl(GRCz10):ENSDARG00000038867 (1)
  • ORTHOLOGY for shhb (Chr: 2)
    Species Symbol Chromosome Accession # Evidence
    Human SHH 7
  • Gene:6469
  • OMIM:600725
  • HGNC:10848
  • Amino acid sequence comparison (5)
    Conserved genome location (synteny) (1)
    Mouse Shh 5
  • MGI:98297
  • Gene:20423
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (134)