ZFIN ID: ZDB-GENE-980526-41
Gene Name: sonic hedgehog signaling molecule b
Gene Symbol: shhb    Nomenclature History

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Previous Names: tiggy winkle hedgehog, twh, twhh

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and patched binding activity. Involved in several processes, including embryonic cranial skeleton morphogenesis; endocardial cell differentiation; and nervous system development. Predicted to localize to extracellular space. Is expressed in several structures, including axis; forebrain; head; neural keel; and neural plate. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Orthologous to human SHH (sonic hedgehog signaling molecule).
Genome Resources: Alliance (1),  Gene:30444 (1),  Ensembl(GRCz11):ENSDARG00000038867 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023573Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028783Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2069 Point Mutation Unknown Premature Stop ENU
    sa5719 Point Mutation Unknown Premature Stop ENU
    sa8431 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25111 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-shhb N/A 3
    MO2-shhb N/A 12
    MO3-shhb N/A 4
    MO4-shhb N/A 1
    MO5-shhb N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH shhb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    holoprosencephaly 3 Alliance Holoprosencephaly 3 142945
    solitary median maxillary central incisor Alliance Single median maxillary central incisor 147250
    Microphthalmia with coloboma 5 611638
    Schizencephaly 269160
    DISEASE ASSOCIATED WITH shhb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic neurocranium morphogenesis (more)
    Cellular Component extracellular region (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA shhb-201 (1)    Ensembl 2019
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM shhb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Et(shhb:GAL4TA4,UAS:mCherry) shhb GAL4TA4mCherry Danio rerio 1 5
    Et(shhb:KALTA4,UAS-E1B:mCherry) E1BshhbUAS KALTA4mCherry Danio rerio 23 45
    Tg(-5.2shhb:GFP) shhb GFP Danio rerio 1 6
    Tg(shhb:GAL4) shhb GAL4 Danio rerio 1 4
    Tg(shhb:GAL4TA4,5xUAS:mRFP) shhb GAL4TA4mRFP Danio rerio 1 5
    MARKER RELATIONSHIPS
    shhb Contained in: [BAC] DKEY-265A7 (1) (order this)
    shhb Encodes: [EST] eu390 (1)
    [cDNA] MGC:101003 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131199 (1) 1990 nt
    Genomic GenBank:BX510360 (1) 213323 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0B5JJZ7 (1) 416 aa
    Sequence Information (all 20)
    ORTHOLOGY for shhb ( Chr: 2 )
    CITATIONS (153)