ZFIN ID: ZDB-GENE-980526-41
Gene Name: sonic hedgehog b
Gene Symbol: shhb

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: tiggy winkle hedgehog, twh, twhh

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 2 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 47 figures from 36 publications
Directly Submitted Expression Data: 7 figures (30 images) from Thisse et al., 2005 [eu390]
Wild-type Stages, Structures: Blastula:256-cell (2.5h-2.75h) to Adult (90d-730d, breeding adult)
  axis, diencephalon, endoderm, floor plate (all 24) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023573Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028783Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2069 Point Mutation Unknown Premature Stop ENU
    sa5719 Point Mutation Unknown Premature Stop ENU
    sa8431 Point Mutation Unknown Premature Stop ENU
    sa25111 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: MO1-shhb (1), MO2-shhb (1), MO3-shhb (1), MO4-shhb (1)
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in: blood circulation, odontogenesis, somite
    DISEASE ASSOCIATED WITH shhb HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    holoprosencephaly Holoprosencephaly 3 142945
    Schizencephaly 269160
    Single median maxillary central incisor 147250
    Microphthalmia with coloboma 5 611638
    Ontology GO Term
    Biological Process embryonic neurocranium morphogenesis (more)
    Cellular Component extracellular region (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000320 (1)
  • InterPro:IPR001657 (1)
  • InterPro:IPR001767 (1)
  • InterPro:IPR003586 (1)
  • InterPro:IPR003587 (1)
  • InterPro:IPR009045 (1)
  • InterPro:IPR028992 (1)
  • Pfam:PF01079 (1)
  • Pfam:PF01085 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA shhb-001 (1) 2019
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM shhb
    Et(shhb:GAL4TA4,UAS:mCherry), Et(shhb:KALTA4,UAS-E1b:mCherry), Tg(-5.2shhb:GFP), Tg(shhb:GAL4), Tg(shhb:GAL4TA4,5xUAS:mRFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    shhbContained in: [BAC] DKEY-265A7 (1) (order this)
    shhbEncodes: [EST] eu390 (1)
    [cDNA] MGC:101003 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131199 (1) 1990bp
    Genomic GenBank:BX510360 (1) 213323bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0B5JJZ7 (1) 416aa
    Sequence Clusters UniGene:75752 (1)
    Sequence Information (all 21)
    OTHER shhb GENE PAGES
  • Gene:30444 (1)
  • VEGA:OTTDARG00000018411 (1)
  • Ensembl(GRCz10):ENSDARG00000038867 (1)
  • ORTHOLOGY for shhb (Chr: 2)
    CITATIONS (136)