ZFIN ID: ZDB-GENE-980526-406
Gene Name: orthodenticle homeobox 2
Gene Symbol: otx2

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: zotx-2, zOtx2 (1), etID309955.17 (1), id:ibd2915, zgc:136535

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 195 figures from 144 publications
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd2915]
Wild-type Stages, Structures: Blastula:Dome (4.33h-4.66h) to Adult (90d-730d, breeding adult)
  anatomical structure, anterior neural plate, anterior presumptive neural plate, axial hypoblast (all 70) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3237 Point Mutation Unknown Premature Stop ENU
hu3625 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36505 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: MO1-otx2 (1), MO2-otx2 (1), MO3-otx2 (1)
    PHENOTYPE
    Data: Fig. 3 from Chassaing et al., 2012
    Observed in: ceratobranchial cartilage, eye, mandibular arch skeleton
    DISEASE ASSOCIATED WITH otx2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hypopituitarism Pituitary hormone deficiency, combined, 6 613986
    microphthalmia Microphthalmia, syndromic 5 610125
    Retinal dystrophy, early-onset, with or without pituitary dysfunction 610125
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to alcohol (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003022 (1)
  • InterPro:IPR003025 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR013851 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF03529 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA otx2-001 (1) 2212
    otx2-002 (1) 2162
    otx2-003 (1) 922
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM otx2
    Tg(otx2:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    otx2Contained in: [BAC] DKEY-166F24 (1) (order this)
    otx2Encodes: [EST] ibd2915 (1) (order this)
    [cDNA] MGC:136535 (1) (order this), MGC:191828 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131251 (1) 2161bp
    Genomic GenBank:CR936482 (1) 39394bp
    Select Tool
    Polypeptide UniProtKB:Q1RM25 (1) 289aa
    Sequence Clusters UniGene:334 (1)
    Sequence Information (all 24)
    OTHER otx2 GENE PAGES
  • Gene:30501 (1)
  • VEGA:OTTDARG00000020531 (1)
  • Ensembl(GRCz10):ENSDARG00000011235 (1)
  • ORTHOLOGY for otx2 (Chr: 17)
    Species Symbol Chromosome Accession # Evidence
    Human OTX2 14
  • Gene:5015
  • OMIM:600037
  • HGNC:8522
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (1)
    Mouse Otx2 14
  • MGI:97451
  • Gene:18424
  • Amino acid sequence comparison (5)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (267)