Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-406
Gene Name: orthodenticle homeobox 2
Gene Symbol: otx2
Previous Names: zotx-2, zOtx2 (1), etID309955.17 (1), id:ibd2915, zgc:136535
Location: Chr: 17   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 171 figures from 125 publications
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd2915]
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
  anterior neural plate, blastoderm, blastoderm dorsal region, brain (all 44) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 5 genotypes
Alleles: hu3237, hu3625
Knockdown reagents: MO1-otx2 (1), MO2-otx2 (1), MO3-otx2 (1)
PHENOTYPE
Data: Fig. 3 from Chassaing et al., 2012
Observed in: ceratobranchial cartilage, eye, mandibular arch skeleton

Phenotype of Human Orthologue OMIM Phenotype ID
Microphthalmia, syndromic 5 610125
Pituitary hormone deficiency, combined, 6 613986
Retinal dystrophy, early-onset, and pituitary dysfunction 610125
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular response to alcohol (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003022 (1)
  • InterPro:IPR003025 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR013851 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF03529 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA otx2-001 (1) 2212
    otx2-002 (1) 2162
    otx2-003 (1) 922
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM otx2
    Tg(otx2:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    otx2 Contained in: [BAC] DKEY-166F24 (1)
    otx2 Encodes: [EST] ibd2915 (1) (order this)
    [cDNA] MGC:136535 (1) (order this), MGC:191828 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131251 (1) 2161 bp
    Genomic GenBank:CR936482 (1) 39394 bp
    Select Tool
    Polypeptide UniProtKB:Q1RM25 (1) 289 aa
    Sequence Clusters UniGene:334 (1)
    Sequence Information (all 22)
    OTHER otx2 GENE PAGES
  • Gene:30501 (1)
  • VEGA:OTTDARG00000020531 (1)
  • Ensembl(Zv9):ENSDARG00000011235 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish otx2 17  
    Human OTX2 14 (14q22.3)
  • OMIM:600037
  • Gene:5015
  • Mouse Otx2 14 ( 25.36 cM)
  • MGI:97451
  • Gene:18424
  • Orthology Details
    CITATIONS (227)