Gene

otx2b

ID
ZDB-GENE-980526-406
Name
orthodenticle homeobox 2b
Symbol
otx2b Nomenclature History
Previous Names
  • otx2
  • zotx-2
  • zOtx2 (1)
  • etID309955.17 (1)
  • id:ibd2915
  • zgc:136535
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in brain development; cellular response to alcohol; and retinal pigment epithelium development. Predicted to localize to nucleus. Is expressed in several structures, including immature eye; nervous system; neural plate; neural rod; and presumptive structure. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Orthologous to human OTX2 (orthodenticle homeobox 2).
Genome Resources
Note
None
Expression
All Expression Data
242 figures from 174 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With otx2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypopituitarism Alliance Pituitary hormone deficiency, combined, 6 613986
syndromic microphthalmia 5 Alliance Microphthalmia, syndromic 5 610125
syndromic microphthalmia 5 Alliance Retinal dystrophy, early-onset, with or without pituitary dysfunction 610125
Associated With otx2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR013851 Transcription factor Otx, C-terminal
Family IPR003022 Transcription factor Otx2
Family IPR003025 Transcription factor Otx
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Transcription factor Otx Transcription factor Otx2 Transcription factor Otx, C-terminal
UniProtKB:Q1RM25 289
UniProtKB:X1WDF1 205
UniProtKB:Q91981 289
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations