ZFIN ID: ZDB-GENE-980526-406
Gene Name: orthodenticle homeobox 2b
Gene Symbol: otx2b
Sequence Ontology ID : SO:0000704

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Previous Names: otx2, zotx-2, zOtx2 (1), etID309955.17 (1), id:ibd2915, zgc:136535

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Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 233 figures from 166 publications
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd2915]
Wild-type Stages, Structures: Blastula:Dome (4.33h-4.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3237 Point Mutation Unknown Premature Stop ENU
hu3625 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36505 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tud44a Small Deletion 5' UTR Unknown CRISPR
    tud44Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
    Targeting reagents:
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH otx2b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hypopituitarism Pituitary hormone deficiency, combined, 6 613986
    microphthalmia Microphthalmia, syndromic 5 610125
    Retinal dystrophy, early-onset, with or without pituitary dysfunction 610125
    DISEASE ASSOCIATED WITH otx2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to alcohol (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003022 (1)
  • InterPro:IPR003025 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR013851 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF03529 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA otx2-001 (1) 2212
    otx2-002 (1) 2162
    otx2-003 (1) 922
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM otx2b
    MARKER RELATIONSHIPS
    otx2bContained in: [BAC] DKEY-166F24 (1) (order this)
    otx2bEncodes: [EST] ibd2915 (1) (order this)
    [cDNA] MGC:136535 (1) (order this), MGC:191828 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131251 (1) 2161bp
    Genomic GenBank:CR936482 (1) 39394bp
    Select Tool
    Polypeptide UniProtKB:Q1RM25 (1) 289aa
    Sequence Clusters UniGene:334 (1)
    Sequence Information (all 25)
    OTHER otx2b GENE PAGES
  • Alliance (1)
  • Gene:30501 (1)
  • VEGA:OTTDARG00000020531 (1)
  • Ensembl(GRCz11):ENSDARG00000011235 (1)
  • ORTHOLOGY for otx2b (Chr: 17)
    CITATIONS (299)