ZFIN ID: ZDB-GENE-980526-406
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Gene Name: orthodenticle homeobox 2
Gene Symbol: otx2
Sequence Ontology ID : SO:0000704

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Previous Names: zotx-2, zOtx2 (1), etID309955.17 (1), id:ibd2915, zgc:136535

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(Including Attributions)
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 201 figures from 148 publications
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd2915]
Wild-type Stages, Structures: Blastula:Dome (4.33h-4.66h) to Adult (90d-730d, breeding adult)
  anatomical structure, anterior neural plate, anterior presumptive neural plate, axial hypoblast (all 71) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3237 Point Mutation Unknown Premature Stop ENU
hu3625 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa36505 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: MO1-otx2 (1), MO2-otx2 (1), MO3-otx2 (1)
    PHENOTYPE
    Data: Fig. 3 from Chassaing et al., 2012
    Observed in: ceratobranchial cartilage, eye, mandibular arch skeleton
    DISEASE ASSOCIATED WITH otx2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hypopituitarism Pituitary hormone deficiency, combined, 6 613986
    microphthalmia Microphthalmia, syndromic 5 610125
    Retinal dystrophy, early-onset, with or without pituitary dysfunction 610125
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to alcohol (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003022 (1)
  • InterPro:IPR003025 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR013851 (1)
  • InterPro:IPR017970 (1)
    		•
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
    		•
  • Pfam:PF00046 (1)
  • Pfam:PF03529 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA otx2-001 (1) 2212
    Select Tool
    otx2-002 (1) 2162
    Select Tool
    otx2-003 (1) 922
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM otx2
    Tg(otx2:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    otx2Contained in: [BAC] DKEY-166F24 (1) (order this)
    otx2Encodes: [EST] ibd2915 (1) (order this)
    [cDNA] MGC:136535 (1) (order this), MGC:191828 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131251 (1) 2161bp
    Select Tool
    Genomic GenBank:CR936482 (1) 39394bp
    Select Tool
    Polypeptide UniProtKB:Q1RM25 (1) 289aa
    Select Tool
    Sequence Clusters UniGene:334 (1)
    Sequence Information (all 24)
    OTHER otx2 GENE PAGES
  • Gene:30501 (1)
  • VEGA:OTTDARG00000020531 (1)
  • Ensembl(GRCz10):ENSDARG00000011235 (1)
    • ORTHOLOGY for otx2 (Chr: 17)
    CITATIONS (276)