ZFIN ID: ZDB-GENE-980526-406
Gene Name: orthodenticle homeobox 2
Gene Symbol: otx2
Previous Names: zotx-2, zOtx2 (1), etID309955.17 (1), id:ibd2915, zgc:136535
Location: Chr: 17   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 187 figures from 137 publications
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd2915]
Wild-type Stages, Structures: Blastula:Dome (4.33h-4.66h) to Adult (90d-730d, breeding adult)
  anatomical structure, anterior neural plate, anterior presumptive neural plate, axial hypoblast (all 67) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 5 Genotypes
Knockdown reagents: MO1-otx2 (1), MO2-otx2 (1), MO3-otx2 (1)

Allele Type Mutagen Suppliers
hu3237 Point Mutation ENU
hu3625 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: Fig. 3 from Chassaing et al., 2012
    Observed in: ceratobranchial cartilage, eye, mandibular arch skeleton

    Phenotype of Human Orthologue OMIM Phenotype ID
    Microphthalmia, syndromic 5 610125
    Pituitary hormone deficiency, combined, 6 613986
    Retinal dystrophy, early-onset, and pituitary dysfunction 610125
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to alcohol (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003022 (1)
  • InterPro:IPR003025 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR013851 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF03529 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA otx2-001 (1) 2212
    otx2-002 (1) 2162
    otx2-003 (1) 922
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM otx2
    Tg(otx2:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    otx2 Contained in: [BAC] DKEY-166F24 (1) (order this)
    otx2 Encodes: [EST] ibd2915 (1) (order this)
    [cDNA] MGC:136535 (1) (order this), MGC:191828 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131251 (1) 2161 bp
    Genomic GenBank:CR936482 (1) 39394 bp
    Select Tool
    Polypeptide UniProtKB:Q1RM25 (1) 289 aa
    Sequence Clusters UniGene:334 (1)
    Sequence Information (all 24)
    OTHER otx2 GENE PAGES
  • Gene:30501 (1)
  • VEGA:OTTDARG00000020531 (1)
  • Ensembl(Zv9):ENSDARG00000011235 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish otx2 17  
    Human OTX2 14 (14q22.3)
  • OMIM:600037
  • Gene:5015
  • Mouse Otx2 14 ( 25.36 cM)
  • MGI:97451
  • Gene:18424
  • Orthology Details
    CITATIONS (239)