Gene

sox3

ID
ZDB-GENE-980526-333
Name
SRY-box transcription factor 3
Symbol
sox3 Nomenclature History
Previous Names
  • id:ibd2036 (1)
  • sb:cb493 (1)
  • wu:fd02a08 (1)
  • zgc:110279 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Contributes to DNA-binding transcription factor activity. Involved in several processes, including nervous system development; otic placode development; and otic placode formation. Predicted to localize to nuclear chromatin. Is expressed in several structures, including ectoderm; nervous system; neural keel; neural tube; and presumptive structure. Human ortholog(s) of this gene implicated in X-linked panhypopituitarism. Orthologous to human SOX3 (SRY-box transcription factor 3).
Genome Resources
Note
None
Expression
All Expression Data
101 figures from 50 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
16 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sox3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
X-linked panhypopituitarism Alliance Panhypopituitarism, X-linked 312000
Mental retardation, X-linked, with isolated growth hormone deficiency 300123
Associated With sox3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009071 High mobility group box domain
Family IPR022097 Transcription factor SOX
Homologous_superfamily IPR036910 High mobility group box domain superfamily
Domain Details Per Protein
Protein Length High mobility group box domain High mobility group box domain superfamily Transcription factor SOX
UniProtKB:Q6EJB7 300
UniProtKB:A9JSZ3 300
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-sox3 polyclonal IgG Rabbit
  • IHC
  • WB
GeneTex
3
Ab1-Sox3 polyclonal Rabbit
  • IHC
1
Ab4-sox2 polyclonal IgG Goat
  • WB
R&D Systems
6
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations