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ZIRC
ZFIN ID: ZDB-GENE-030321-1
Gene Name: GLI family zinc finger 1
Gene Symbol: gli1    Nomenclature History

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Previous Names: detour, dtr

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have DNA binding activity and metal ion binding activity. Involved in several processes, including muscle cell fate specification; nervous system development; and positive regulation of smoothened signaling pathway. Localizes to the Hedgehog signaling complex. Is expressed in several structures, including central nervous system; head; neural plate; neural tube; and paraxial mesoderm. Orthologous to human GLI1 (GLI family zinc finger 1).
Genome Resources: Alliance (1),  Gene:352930 (1),  Ensembl(GRCz11):ENSDARG00000101244 (1)
GENE EXPRESSION
All Expression Data: 46 figures from 35 publications
Directly Submitted Expression Data: 6 figures (15 images) from Thisse et al., 2005 [eu934]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gli1_unspecified Unspecified Unknown Unknown
la028128Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8554 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31210 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32697 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38271 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • te370a Point Mutation Unknown Premature Stop ENU
    tm276b Point Mutation Unknown Missense ENU
    ts269 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko599a Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gli1 1
    MO1-gli1 N/A 12
    MO2-gli1 N/A 1
    DISEASE ASSOCIATED WITH gli1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Polydactyly, postaxial, type A8 618123
    Polydactyly, preaxial I 174400
    DISEASE ASSOCIATED WITH gli1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component Hedgehog signaling complex (more)
    Molecular Function protein binding (more)
    GO Terms (all 31)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gli1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(bitetre:gli1,nls-mcherry) TETRE gli1mCherryNLS Danio rerio 0 1
    Tg(gli1:GFP) gli1 GFP Danio rerio 1 2
    Tg(hsp70l:GFP-gli1) hsp70l GFPgli1 Danio rerio 1 3
    Tg(hsp70l:gli1) hsp70l gli1 Danio rerio 1 2
    Tg(hsp70l:gli1-EGFP) hsp70l EGFPgli1 Danio rerio 1 3
    MARKER RELATIONSHIPS
    gli1 Encodes: [EST] eu934 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_178296 (1) 4726 bp
    Genomic GenBank:CU855923 (1) 81257 bp
    Select Tool
    Polypeptide UniProtKB:F1QAC4 (1) 1404 aa
    Sequence Clusters UniGene:88778 (1)
    Sequence Information (all 12)
    ORTHOLOGY for gli1 ( Chr: 6 )
    CITATIONS (141)