ZFIN ID: ZDB-GENE-980526-44
Gene Name: patched 2
Gene Symbol: ptch2    Nomenclature History

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Previous Names: ptc-1, ptc1, blowout (1), blw (1), etID309849.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in several processes, including cardioblast differentiation; negative regulation of smoothened signaling pathway; and retinal ganglion cell axon guidance. Predicted to localize to plasma membrane. Is expressed in several structures, including central nervous system; digestive system; head; mesoderm; and musculature system. Used to study coloboma. Human ortholog(s) of this gene implicated in basal cell carcinoma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH2 (patched 2).
Genome Resources: Alliance (1),  Gene:30181 (1),  Ensembl(GRCz11):ENSDARG00000055026 (2)
GENE EXPRESSION
All Expression Data: 193 figures from 136 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2005 [eu467]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
au1 Point Mutation Acceptor Splice Site of Intron 4 Unknown ENU
hu1602 Point Mutation Donor Splice Site of Intron 10 Unknown ENU
la010757Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014919Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028797Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19807 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38340 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39869 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44536 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tc294z Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ptch2 N/A 10
    MO2-ptch2 N/A 1
    MO3-ptch2 N/A 2
    MO4-ptch2 N/A 1
    DISEASE ASSOCIATED WITH ptch2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    medulloblastoma Alliance Medulloblastoma, somatic 155255
    nevoid basal cell carcinoma syndrome Alliance Basal cell nevus syndrome 109400
    Basal cell carcinoma, somatic 605462
    DISEASE ASSOCIATED WITH ptch2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    coloboma ptch2tc294z/tc294z standard conditions Gordon et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardioblast differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function hedgehog receptor activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ptch2-202 (1)    Ensembl 4420
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ptch2 Goat IHC Everest Biotech
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ptch2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(GBS-ptch2:EGFP) ptch2 EGFP Danio rerio 1 7
    Tg(GBS-ptch2:EGFP-CAAX) ptch2 EGFP Danio rerio 1 2
    Tg(GBS-ptch2:h2az2a-mCherry) GBSptch2 h2az2amCherry Danio rerio 1 1
    Tg(GBS-ptch2:mCherry) ptch2 mCherry Danio rerio 1 2
    Tg(GBS-ptch2:mCherry-CAAX) ptch2 mCherry Danio rerio 1 2
    Tg(GBS-ptch2:NLS-EGFP) ptch2 EGFP Danio rerio 1 6
    Tg(GBS-ptch2:NLS-mCherry) ptch2 mCherry Danio rerio 1 2
    tg(gbs-ptch2:rtta-ha) GBSptch2 HARTTA Danio rerio 0 1
    TgBAC(ptch2:HA-EGFP) ptch2 EGFP Danio rerio 1 3
    TgBAC(ptch2:Kaede) ptch2 Kaede Danio rerio 1 9
    MARKER RELATIONSHIPS
    ptch2 Contained in: [BAC] CH211-226H23 (1)
    ptch2 Encodes: [EST] eu467 (1)
    [cDNA] MGC:162571 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_130988 (1) 3672 nt
    Genomic GenBank:BX649493 (1) 175551 nt
    Select Tool
    Polypeptide UniProtKB:F1Q8S0 (1) 1442 aa
    Sequence Information (all 17)
    ORTHOLOGY for ptch2 ( Chr: 2 )
    CITATIONS (289)