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ZIRC
ZFIN ID: ZDB-GENE-980526-44
Gene Name: patched 2
Gene Symbol: ptch2
Sequence Ontology ID : SO:0000704

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Previous Names: ptc-1, ptc1, blowout (1), blw (1), etID309849.2 (1)

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(Including Attributions)
Location: Chr: 2 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in several processes, including animal organ development; negative  ...
GENE EXPRESSION
All Expression Data: 193 figures from 135 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2005 [eu467]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
au1 Point Mutation Acceptor Splice Site of Intron 4 Unknown ENU
hu1602 Point Mutation Donor Splice Site of Intron 10 Unknown ENU
la010757Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014919Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028797Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19807 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38340 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39869 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44536 Point Mutation Unknown Unknown ENU
    tc294z Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH ptch2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    medulloblastoma Medulloblastoma, somatic 155255
    nevoid basal cell carcinoma syndrome Basal cell nevus syndrome 109400
    Basal cell carcinoma, somatic 605462
    DISEASE ASSOCIATED WITH ptch2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    coloboma ptch2tc294z/tc294z standard conditions Gordon et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardioblast differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function hedgehog receptor activity (more)
    GO Terms (all 14)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ptch2-202 (1) 4420
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    PLASMIDSNo data available
    MARKER RELATIONSHIPS
    ptch2Contained in: [BAC] CH211-226H23 (1) (order this)
    ptch2Encodes: [EST] eu467 (1)
    [cDNA] MGC:162571 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130988 (1) 3672bp
    Genomic GenBank:BX649493 (1) 175551bp
    Select Tool
    Polypeptide UniProtKB:F1Q8S0 (1) 1442aa
    Sequence Clusters UniGene:75755 (1)
    Sequence Information (all 18)
    ORTHOLOGY for ptch2 (Chr: 2)
    CITATIONS (282)