ZFIN ID: ZDB-GENE-980526-44
Gene Name: patched 2
Gene Symbol: ptch2
Sequence Ontology ID : SO:0000704

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Previous Names: ptc-1, ptc1, blowout (1), blw (1), etID309849.2 (1)

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(Including Attributions)
Location: Chr: 2 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 179 figures from 123 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2005 [eu467]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Days 21-29 (21d-30d, 7.8mm, 10 teeth)
  adaxial cell, anatomical structure, axial hypoblast, axis (all 83) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
au1 Point Mutation Acceptor Splice Site of Intron 4 Unknown ENU
hu1602 Point Mutation Unknown Unknown ENU
la010757Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014919Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028797Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19807 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38340 Point Mutation Unknown Premature Stop ENU
    sa39869 Point Mutation Unknown Splice Site ENU
    tc294z Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-ptch2 (1), MO2-ptch2 (1), MO3-ptch2 (1)
    PHENOTYPE
    Data: 20 figures from 8 publications
    Observed in: brain, caudal fin skeleton osteoclast, ceratohyal cartilage, diencephalon (all 40) expand
    DISEASE ASSOCIATED WITH ptch2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    basal cell carcinoma Basal cell carcinoma, somatic 605462
    medulloblastoma Medulloblastoma 155255
    nevoid basal cell carcinoma syndrome Basal cell nevus syndrome 109400
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardioblast differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function hedgehog receptor activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000731 (1)
  • InterPro:IPR003392 (1)
  • InterPro:IPR004766 (1)
  • PROSITE:PS50156 (1)
  • Pfam:PF02460 (1)
  • Pfam:PF12349 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ptch2-001 (1) 4420
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Ab1-ptch2 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ptch2
    Tg(GBS-ptch2:EGFP), Tg(GBS-ptch2:EGFP-CAAX), Tg(GBS-ptch2:mCherry), Tg(GBS-ptch2:mCherry-CAAX), Tg(GBS-ptch2:NLS-EGFP) (all 8) expand
    MARKER RELATIONSHIPS
    ptch2Contained in: [BAC] CH211-226H23 (1) (order this)
    ptch2Encodes: [EST] eu467 (1)
    [cDNA] MGC:162571 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130988 (1) 3672bp
    Genomic GenBank:BX649493 (1) 175551bp
    Select Tool
    Polypeptide UniProtKB:F1Q8S0 (1) 1442aa
    Sequence Clusters UniGene:75755 (1)
    Sequence Information (all 18)
    OTHER ptch2 GENE PAGES
  • Alliance (1)
  • Gene:30181 (1)
  • VEGA:OTTDARG00000019874 (1)
  • Ensembl(GRCz10):ENSDARG00000055026 (1)
  • ORTHOLOGY for ptch2 (Chr: 2)
    CITATIONS (256)