Gene

ptch2

ID
ZDB-GENE-980526-44
Name
patched 2
Symbol
ptch2 Nomenclature History
Previous Names
  • ptc-1
  • ptc1
  • blowout (1)
  • blw (1)
  • etID309849.2 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in several processes, including cardioblast differentiation; negative regulation of smoothened signaling pathway; and retinal ganglion cell axon guidance. Predicted to localize to plasma membrane. Is expressed in several structures, including central nervous system; digestive system; head; mesoderm; and musculature system. Used to study coloboma. Human ortholog(s) of this gene implicated in basal cell carcinoma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH2 (patched 2).
Genome Resources
Note
None
Expression
All Expression Data
194 figures from 137 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
29 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptch2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
medulloblastoma Alliance Medulloblastoma, somatic 155255
nevoid basal cell carcinoma syndrome Alliance Basal cell nevus syndrome 109400
Basal cell carcinoma, somatic 605462
Associated With ptch2 Via Experimental Models
Human Disease Fish Conditions Citations
coloboma ptch2tc294z/tc294z standard conditions Gordon et al., 2018
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000731 Sterol-sensing domain
Family IPR003392 Protein patched/dispatched
Family IPR004766 Transmembrane receptor, patched
Domain Details Per Protein
Protein Length Protein patched/dispatched Sterol-sensing domain Transmembrane receptor, patched
UniProtKB:Q98864 1220
UniProtKB:F1R837 1383
UniProtKB:A4QP09 108
UniProtKB:F1Q8S0 1442
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ptch2 Goat
  • IHC
Everest Biotech
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations