Gene

six3b

ID
ZDB-GENE-990415-128
Name
SIX homeobox 3b
Symbol
six3b Nomenclature History
Previous Names
  • six3.2
  • six6 (1)
  • cb347 (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic camera-type eye morphogenesis; nervous system development; and sensory epithelium regeneration. Predicted to localize to nucleus and transcription regulator complex. Is expressed in several structures, including ectoderm; hypoblast; immature eye; nervous system; and neural keel. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3).
Genome Resources
Note
None
Expression
All Expression Data
71 figures from 47 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With six3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
holoprosencephaly 2 Alliance Holoprosencephaly 2 157170
Schizencephaly 269160
Associated With six3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001356 Homeobox domain
Domain IPR031701 Homeobox protein SIX1, N-terminal SD domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox domain Homeobox-like domain superfamily Homeobox protein SIX1, N-terminal SD domain
UniProtKB:O73709 293
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations