Gene

cdh2

ID
ZDB-GENE-990415-171
Name
cadherin 2, type 1, N-cadherin (neuronal)
Symbol
cdh2 Nomenclature History
Previous Names
  • bib
  • glass onion (1)
  • glo (1)
  • labyrinth (1)
  • lyr (1)
  • n-cadherin (1)
  • ncad
  • neural cadherin
  • pac (1)
  • parachute (1)
  • wu:fb47h04
  • zncad
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have cadherin binding activity; calcium ion binding activity; and cytoskeletal protein binding activity. Involved in several processes, including animal organ development; embryonic morphogenesis; and nervous system development. Localizes to catenin complex; perinuclear region of cytoplasm; and presynaptic membrane. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy. Is expressed in several structures, including germ ring; immature eye; mesoderm; nervous system; and pericardial region. Orthologous to human CDH2 (cadherin 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
61 figures from 40 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
93 figures from 32 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
cdh2_unspecifiedUnspecified AlleleUnknownUnknownnot specified
fr7Allele with one point mutationUnknownPremature StopENU
hi1389TgTransgenic insertionIntron 2UnknownDNA
hi3096TgTransgenic insertionIntron 2UnknownDNA
hi3644TgTransgenic insertionIntron 2UnknownDNA
la013796TgTransgenic insertionUnknownUnknownDNA
la021425TgTransgenic insertionUnknownUnknownDNA
la021426TgTransgenic insertionUnknownUnknownDNA
la021427TgTransgenic insertionUnknownUnknownDNA
m117Allele with one point mutationUnknownMissenseENU
1 - 10 of 28
Show
Sequence Targeting Reagents
Human Disease
Associated With cdh2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
agenesis of corpus callosum, cardiac, ocular, and genital syndrome Alliance Agenesis of corpus callosum, cardiac, ocular, and genital syndrome 618929
arrhythmogenic right ventricular dysplasia 14 Alliance Arrhythmogenic right ventricular dysplasia 14 618920
?Attention deficit-hyperactivity disorder 8 619957
1 - 3 of 3
Associated With cdh2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020894 Cadherin conserved site
Domain IPR000233 Cadherin, Y-type LIR-motif
Domain IPR002126 Cadherin-like
Domain IPR014868 Cadherin prodomain
Family IPR039808 Cadherin
1 - 5 of 7 Show all
Domain Details Per Protein
Protein Length Cadherin Cadherin conserved site Cadherin-like Cadherin-like superfamily Cadherin prodomain Cadherin, Y-type LIR-motif Catenin binding domain superfamily
UniProtKB:Q90275 893
UniProtKB:Q1L8K3 893
1 - 2 of 2
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 20
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cdh2-201 (1) Ensembl 4,853 nt
mRNA cdh2-202 (1) Ensembl 2,429 nt
mRNA cdh2-203 (1) Ensembl 2,809 nt
1 - 3 of 3
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pan-Cadherin polyclonal Rabbit
  • IHC
  • WB
Sigma-Aldrich
29
Ab4-cdh2 polyclonal Rabbit
  • WB
2
Ab1-cdh2 polyclonal Rabbit
  • IHC
  • WB
9
1 - 3 of 3
Plasmids
Constructs
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-317E11ZFIN Curated Data
Contained inBACDKEYP-38F5ZFIN Curated Data
EncodesESTfb47h04
EncodesESTft03g07
EncodescDNAMGC:158217ZFIN Curated Data
1 - 5 of 5
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCDH218
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseCdh218
Amino acid sequence comparison (1)
Citations
1 - 10 of 191
Show