ZFIN ID: ZDB-GENE-990415-171
Gene Name: cadherin 2, type 1, N-cadherin (neuronal)
Gene Symbol: cdh2    Nomenclature History

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Previous Names: bib, glass onion (1), glo (1), labyrinth (1), lyr (1), n-cadherin (1), ncad, neural cadherin, pac (1), parachute (1), wu:fb47h04, zncad

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have cadherin binding activity; calcium ion binding activity; and cytoskeletal protein binding activity. Involved in several processes, including animal organ development; embryonic morphogenesis; and nervous system development. Localizes to catenin complex; perinuclear region of cytoplasm; and presynaptic membrane. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy. Is expressed in several structures, including germ ring; immature eye; mesoderm; nervous system; and pericardial region. Orthologous to human CDH2 (cadherin 2).
Genome Resources: Alliance (1),  Gene:30291 (1),  Ensembl(GRCz11):ENSDARG00000018693 (1)
GENE EXPRESSION
All Expression Data: 58 figures from 37 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cdh2_unspecified Unspecified Unknown Unknown
fr7 Point Mutation Unknown Premature Stop ENU
hi1389Tg Transgenic Insertion Intron 2 Unknown DNA
hi3096Tg Transgenic Insertion Intron 2 Unknown DNA
hi3644Tg Transgenic Insertion Intron 2 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la013796Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021425Tg Transgenic Insertion Unknown Unknown DNA
    la021426Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021427Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m117 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • p79emcf Point Mutation Unknown Missense ENU
    r210 Point Mutation Unknown Unknown ENU
    rw95 Point Mutation Unknown Missense ENU
    rw707 Unknown Unknown Unknown
    sa206 Point Mutation Unknown Premature Stop ENU
    sa11989 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15918 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa16882 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32283 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tb8 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tc248c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tg1a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tg299b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tj250a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm101 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • vu91 Point Mutation Unknown Missense ENU
    vu125 Point Mutation Unknown Missense ENU
    wi440Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cdh2
    2
    CRISPR2-cdh2
    2
    CRISPR3-cdh2
    1
    CRISPR4-cdh2
    1
    MO1-cdh2 N/A 29
    MO2-cdh2 N/A 3
    MO3-cdh2 N/A 2
    PHENOTYPE
    Data: 89 figures from 30 publications
    Observed in:
    DISEASE ASSOCIATED WITH cdh2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cdh2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal convergence (more)
    Cellular Component catenin complex (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 73)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdh2-201 (1)    Ensembl 4853
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-pan-Cadherin polyclonal Rabbit IHC, WB Sigma-Aldrich
    26
    Ab4-cdh2 polyclonal Rabbit WB 2
    Ab1-cdh2 polyclonal Rabbit IHC, WB 9
    CONSTRUCTS WITH SEQUENCES FROM cdh2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:cdh2-GFP) hsp70l cdh2GFP Danio rerio 1 1
    Tg(hsp70l:cdh2_W2G-GFP) hsp70l cdh2GFP Danio rerio 1 1
    Tg(isl1-hsp70l:dncdh2-mCherry) hsp70lisl1 cdh2mCherry Danio rerio 2 1
    Tg(myl7:cdh2-Tomato) myl7 cdh2Tomato Danio rerio 1 2
    TgBAC(cdh2:cdh2-EGFP,crybb1:ECFP) cdh2crybb1 cdh2ECFPEGFP Danio rerio 1 8
    tgbac(cdh2:cdh2-mcherry) cdh2 cdh2mCherry Danio rerio 1 1
    TgBAC(cdh2:cdh2-sfGFP-TagRFP,crybb1:ECFP) cdh2 cdh2crybb1ECFPGFPTagRFP Danio rerio 1 10
    TgBAC(cdh2:cdh2-TagRFP,crybb1:ECFP) cdh2crybb1 cdh2ECFPTagRFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    cdh2 Contained in: [BAC] CH73-317E11 (1), DKEYP-38F5 (1)
    cdh2 Encodes: [EST] fb47h04, ft03g07
    [cDNA] MGC:158217 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131081 (1) 2446 nt
    Genomic RefSeq:NW_018395066 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QKB4 (1) 909 aa
    Sequence Information (all 34)
    ORTHOLOGY for cdh2 ( Chr: 20 )
    CITATIONS (190)