Gene

cdh2

ID
ZDB-GENE-990415-171
Name
cadherin 2, type 1, N-cadherin (neuronal)
Symbol
cdh2 Nomenclature History
Previous Names
  • bib
  • glass onion (1)
  • glo (1)
  • labyrinth (1)
  • lyr (1)
  • n-cadherin (1)
  • ncad
  • neural cadherin
  • pac (1)
  • parachute (1)
  • wu:fb47h04
  • zncad
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have cadherin binding activity and calcium ion binding activity. Involved in several processes, including animal organ development; embryonic morphogenesis; and nervous system development. Localizes to catenin complex; perinuclear region of cytoplasm; and presynaptic membrane. Is expressed in several structures, including germ ring; immature eye; mesoderm; nervous system; and pericardial region. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy. Orthologous to human CDH2 (cadherin 2).
Genome Resources
Note
None
Expression
All Expression Data
58 figures from 37 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
89 figures from 30 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdh2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Agenesis of corpus callosum, cardiac, ocular, and genital syndrome 618929
Arrhythmogenic right ventricular dysplasia, familial, 14 618920
Associated With cdh2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020894 Cadherin conserved site
Domain IPR000233 Cadherin, cytoplasmic domain
Domain IPR002126 Cadherin-like
Domain IPR014868 Cadherin prodomain
Family IPR030051 N-cadherin
Family IPR039808 Cadherin
Homologous_superfamily IPR015919 Cadherin-like superfamily
Homologous_superfamily IPR027397 Catenin binding domain superfamily
Domain Details Per Protein
Protein Length Cadherin Cadherin conserved site Cadherin, cytoplasmic domain Cadherin-like Cadherin-like superfamily Cadherin prodomain Catenin binding domain superfamily N-cadherin
UniProtKB:A0A2R8QKB4 909
UniProtKB:Q90275 893
UniProtKB:A0A2R8RZF2 782
UniProtKB:G1K2E7 893
UniProtKB:Q1L8K3 893
UniProtKB:A0A2R8Q5E6 868
UniProtKB:A0A0B5JK11 710
UniProtKB:A0A2R8RN51 869
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pan-Cadherin polyclonal Rabbit
  • IHC
  • WB
Sigma-Aldrich
26
Ab4-cdh2 polyclonal Rabbit
  • WB
2
Ab1-cdh2 polyclonal Rabbit
  • IHC
  • WB
9
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations