Gene
cdh2
- ID
- ZDB-GENE-990415-171
- Name
- cadherin 2, type 1, N-cadherin (neuronal)
- Symbol
- cdh2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have cadherin binding activity; calcium ion binding activity; and cytoskeletal protein binding activity. Involved in several processes, including animal organ development; embryonic morphogenesis; and nervous system development. Localizes to catenin complex; perinuclear region of cytoplasm; and presynaptic membrane. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy. Is expressed in several structures, including germ ring; immature eye; mesoderm; nervous system; and pericardial region. Orthologous to human CDH2 (cadherin 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 61 figures from 40 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 93 figures from 32 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
cdh2_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
fr7 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
hi1389Tg | Transgenic insertion | Intron 2 | Unknown | DNA | |
hi3096Tg | Transgenic insertion | Intron 2 | Unknown | DNA | |
hi3644Tg | Transgenic insertion | Intron 2 | Unknown | DNA | |
la013796Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la021425Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la021426Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la021427Tg | Transgenic insertion | Unknown | Unknown | DNA | |
m117 | Allele with one point mutation | Unknown | Missense | ENU |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
agenesis of corpus callosum, cardiac, ocular, and genital syndrome | Alliance | Agenesis of corpus callosum, cardiac, ocular, and genital syndrome | 618929 |
arrhythmogenic right ventricular dysplasia 14 | Alliance | Arrhythmogenic right ventricular dysplasia 14 | 618920 |
?Attention deficit-hyperactivity disorder 8 | 619957 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Cadherin | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Cadherin prodomain | Cadherin, Y-type LIR-motif | Catenin binding domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q90275
|
893 | |||||||
UniProtKB:Q1L8K3
|
893 |
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Interactions and Pathways
No data available
Plasmids
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-317E11 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-38F5 | ZFIN Curated Data | |
Encodes | EST | fb47h04 | ||
Encodes | EST | ft03g07 | ||
Encodes | cDNA | MGC:158217 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131081 (1) | 4672 nt | ||
Genomic | RefSeq:NW_018395066 (1) | 234239 nt | ||
Polypeptide | UniProtKB:Q1L8K3 (1) | 893 aa |
- Chiang, D.Y., Verkerk, A.O., Victorio, R., Shneyer, B.I., van der Vaart, B., Jouni, M., Narendran, N., Kc, A., Sampognaro, J.R., Vetrano-Olsen, F., Oh, J.S., Buys, E., de Jonge, B., Shah, D.A., Kiviniemi, T., Burridge, P.W., Bezzina, C.R., Akhmanova, A., MacRae, C.A. (2023) The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction. Circulation research. 134(1):46-59
- Ruijmbeek, C.W., Housley, F., Idrees, H., Housley, M.P., Pestel, J., Keller, L., Lai, J.K.H., van der Linde, H.C., Willemsen, R., Piesker, J., Al-Hassnan, Z.N., Almesned, A., Dalinghaus, M., van den Bersselaar, L.M., van Slegtenhorst, M.A., Tessadori, F., Bakkers, J., van Ham, T.J., Stainier, D.Y., Verhagen, J.M., Reischauer, S. (2023) Bi-allelic variants in FLII cause pediatric cardiomyopathy by disrupting cardiomyocyte cell adhesion and myofibril organization. JCI insight. 8(17):
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochemical and Biophysical Research Communications. 652:768376-83
- Zhang, J., Li, P., Sun, L., Jiang, N., Guo, W., Wang, J., Gao, F., Li, J., Li, H., Zhang, J., Mu, H., Hu, Y., Cui, X. (2023) Knockout of miR-184 in zebrafish leads to ocular abnormalities by elevating p21 levels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22927e22927
- Li, J., Xu, Y., Jiang, Y., Li, N., Li, Z., Kong, D., Guo, X., Zhang, J., Zuo, R. (2022) Nongenomic effects and mechanistic study of butyl benzyl phthalate-induced thyroid disruption: Based on integrated in vitro, in silico assays and proteome analysis. The Science of the total environment. 836:155715
- Liu, M., Zou, X., Fu, M., Bai, X., Zhao, Y., Chen, X., Wang, X., Wang, P., Huang, S. (2022) Mild cold stress specifically disturbs clustering movement of DFCs and sequential organ left-right patterning in zebrafish. Frontiers in cell and developmental biology. 10:952844
- Marques, I.J., Ernst, A., Arora, P., Vianin, A., Hetke, T., Sanz-Morejón, A., Naumann, U., Odriozola, A., Langa, X., Andrés-Delgado, L., Zuber, B., Torroja, C., Osterwalder, M., Simões, F., Englert, C., Mercader, N. (2022) WT1 transcription factor impairs cardiomyocyte specification and drives a phenotypic switch from myocardium to epicardium. Development (Cambridge, England). 149(6):
- Mongera, A., Pochitaloff, M., Gustafson, H.J., Stooke-Vaughan, G.A., Rowghanian, P., Kim, S., Campàs, O. (2022) Mechanics of the cellular microenvironment as probed by cells in vivo during zebrafish presomitic mesoderm differentiation. Nature Materials. 22(1):135-143
- Naganathan, S.R., Popović, M., Oates, A.C. (2022) Left-right symmetry of zebrafish embryos requires somite surface tension. Nature. 605(7910):516-521
- Norcross, R.G., Abdelmoti, L., Rouchka, E.C., Andreeva, K., Tussey, O., Landestoy, D., Galperin, E. (2022) Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix. Developmental Biology. 492:156-171
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