- Title
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Fertility impairment with defective spermatogenesis and steroidogenesis in male zebrafish lacking androgen receptor
- Authors
- Tang, H., Chen, Y., Wang, L., Yin, Y., Li, G., Guo, Y., Liu, Y., Lin, H., Cheng, C.H.K., Liu, X.
- Source
- Full text @ Biol. Reprod.
Phenotypic characterization of the ar−/− male zebrafish. (A) Gross and gonad morphology of the ar+/+ and ar−/–fish. The testis size was significantly decreased in the homozygotes. (B–D) Body length (B), body weight (C), and GSI (D) of the ar+/+ and ar−/–fish. (E) The reproductive capacity of males from the indicated genotypes crossed with wild-type females (n = 12). Each value represents the mean value ± SEM (n = 6) (***, P < 0.001 vs control). PHENOTYPE:
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Testicular histology, sperm morphology, and sperm quality of the ar +/+ and ar −/− male zebrafish at 90 dpf. (A) Testicular histology and sperm morphology of adult male zebrafish of ar +/+ and ar −/–genotypes. A pronounced reduction in germ cell number was observed in the ar mutant fish, while a very small number of mature spermatozoa of normal morphology could still be found in the ar mutant fish. (B–D) Sperm motility (B), VCL (C), SRT (D) in adult male zebrafish of the indicated genotypes. (E) Fertilization rate of sperm obtained from the ar mutant fish performed by in vitro fertilization. sz: Spermatozoa; VCL: average curvilinear velocity; STR: average straightness. Each value represents the mean value ± SEM (n = 6) (***, P < 0.001 vs control). PHENOTYPE:
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ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. |
ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. |
ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. |