Gene
hsd3b2
- ID
- ZDB-GENE-030828-2
- Name
- hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
- Symbol
- hsd3b2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Exhibits 3-beta-hydroxy-delta5-steroid dehydrogenase activity. Involved in embryonic morphogenesis and steroid biosynthetic process. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Is expressed in brain; gonad; head kidney; and yolk syncytial layer. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2).
- Genome Resources
- Note
-
The name of this gene was changed because another gene was found to have very strong orthology with human HSD3B1. The current name of this gene, hsd3b2, reflects this gene's relationship to other hsd3b2 genes in fish and not its orthology to human HSD3B2
- Comparative Information
-
- All Expression Data
- 23 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb723 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lin et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | 3-beta hydroxysteroid dehydrogenase/isomerase | Bifunctional lipid A modification and metabolic enzymes | NAD(P)-binding domain superfamily |
|---|---|---|---|---|
|
UniProtKB:Q7ZZC3
|
374 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hsd3b2-201
(1)
|
Ensembl | 1,369 nt | ||
| mRNA |
hsd3b2-202
(1)
|
Ensembl | 1,258 nt |
Interactions and Pathways
No data available
Plasmids
No data available