Gene

hsd3b2

ID
ZDB-GENE-030828-2
Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Symbol
hsd3b2 Nomenclature History
Previous Names
  • hsd3b1
  • 3 beta hsd (1)
  • cb723 (1)
  • zgc:122972
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Exhibits 3-beta-hydroxy-delta5-steroid dehydrogenase activity. Involved in embryonic morphogenesis and steroid biosynthetic process. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Is expressed in brain; gonad; head kidney; and yolk syncytial layer. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2).
Genome Resources
Note
The name of this gene was changed because another gene was found to have very strong orthology with human HSD3B1. The current name of this gene, hsd3b2, reflects this gene's relationship to other hsd3b2 genes in fish and not its orthology to human HSD3B2
Comparative Information
Expression
All Expression Data
22 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Lin et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hsd3b2 Human Ortholog
No data available
Associated With hsd3b2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length 3-beta hydroxysteroid dehydrogenase/isomerase NAD(P)-binding domain superfamily
UniProtKB:F1QR80 374
UniProtKB:Q5RIL8 283
UniProtKB:Q7ZZC3 374
UniProtKB:Q567M6 374
UniProtKB:Q32PQ7 311
UniProtKB:Q5RIL7 374
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations