Gene
cyp17a1
- ID
- ZDB-GENE-040213-2
- Name
- cytochrome P450, family 17, subfamily A, polypeptide 1
- Symbol
- cyp17a1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity and steroid 17-alpha-monooxygenase activity. Acts upstream of or within with a positive effect on female sex determination. Acts upstream of or within with a negative effect on male sex determination. Acts upstream of or within androst-4-ene-3,17-dione biosynthetic process and progesterone metabolic process. Predicted to be located in membrane. Is expressed in brain and endocrine system. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157435 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a259 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb144 | Allele with one deletion | Unknown | Unknown | TALEN | |
| sa7373 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa22316 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35505 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cyp17a1 | (2) | |
| CRISPR2-cyp17a1 | (2) | |
| CRISPR3-cyp17a1 | (2) | |
| CRISPR4-cyp17a1 | (3) | |
| MO1-cyp17a1 | N/A | Hsu et al., 2006 |
| MO2-cyp17a1 | N/A | Vishnolia et al., 2020 |
| TALEN1-cyp17a1 | (9) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital adrenal hyperplasia | Alliance | 17,20-lyase deficiency, isolated | 202110 |
| congenital adrenal hyperplasia | Alliance | 17-alpha-hydroxylase/17,20-lyase deficiency | 202110 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|
|
UniProtKB:B3DH80
|
519 | ||||
|
UniProtKB:A0A8M1PIC7
|
519 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp17a1-201
(1)
|
Ensembl | 2,799 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cyp17a1 | Rabbit |
|
3 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-67N3 | ZFIN Curated Data | |
| Contains | SNP | rs3728563 | ZFIN Curated Data | |
| Contains | SNP | rs3728564 | ZFIN Curated Data | |
| Contains | SNP | rs3728565 | ZFIN Curated Data | |
| Encodes | EST | fi13g04 | ||
| Encodes | EST | fi17b11 | ||
| Encodes | EST | fi31c08 | ||
| Encodes | EST | IMAGE:7157435 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:66494 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136516 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212806 (1) | 2799 nt | ||
| Genomic | GenBank:AL928951 (1) | 183050 nt | ||
| Polypeptide | UniProtKB:A0A8M1PIC7 (1) | 519 aa |
- Jia, J.Y., Chen, G.H., Shu, T.T., Lou, Q.Y., Jin, X., He, J.Y., Xiao, W.H., Zhai, G., Yin, Z. (2024) Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish. Zoological research. 45:355366355-366
- Li, C., Cai, R., Shi, W., Zhang, H., Liu, Z., Xie, F., Chen, Y., Hong, Q. (2024) Comparative transcriptome analysis of ovaries and testes reveals sex-biased genes and pathways in zebrafish. Gene. 901:148176
- Ruan, Y., Li, X., Wang, X., Zhai, G., Lou, Q., Jin, X., He, J., Mei, J., Xiao, W., Gui, J., Yin, Z. (2024) New insights into the all-testis differentiation in zebrafish with compromised endogenous androgen and estrogen synthesis. PLoS Genetics. 20:e1011170e1011170
- Ruan, Y., Li, X., Zhai, G., Lou, Q., Jin, X., He, J., Yin, Z. (2024) Estrogen Signaling Inhibits the Expression of anti-Müllerian hormone (amh) and gonadal-soma-derived factor (gsdf) during the Critical Time of Sexual Fate Determination in Zebrafish. International Journal of Molecular Sciences. 25(3):
- Zanardini, M., Zhang, W., Habibi, H.R. (2024) Arginine Vasotocin Directly Regulates Spermatogenesis in Adult Zebrafish (Danio rerio) Testes. International Journal of Molecular Sciences. 25(12):
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Dai, X., Pradhan, A., Liu, J., Liu, R., Zhai, G., Zhou, L., Dai, J., Shao, F., Yuan, Z., Wang, Z., Yin, Z. (2023) Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions. Biology of sex differences. 14:5353
- Liao, X., Tao, B., Zhang, X., Chen, L., Chen, J., Song, Y., Hu, W. (2023) Loss of gdnfa disrupts spermiogenesis and male courtship behavior in zebrafish. Molecular and Cellular Endocrinology. 576:112010
- Medkova, D., Hollerova, A., Blahova, J., Marsalek, P., Mares, J., Hodkovicova, N., Doubkova, V., Hesova, R., Tichy, F., Faldyna, M., Taştan, Y., Kotoucek, J., Svobodova, Z., Lakdawala, P. (2023) Medicine designed to combat diseases of affluence affects the early development of fish. How do plastic microparticles contribute?. The Science of the total environment. 904:166378
- Wang, X., Zhu, J., Wang, H., Deng, W., Jiao, S., Wang, Y., He, M., Zhang, F., Liu, T., Hao, Y., Ye, D., Sun, Y. (2023) Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Nature communications. 14:79187918
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