ZFIN ID: ZDB-GENE-040213-2
Gene Name: cytochrome P450, family 17, subfamily A, polypeptide 1
Gene Symbol: cyp17a1    Nomenclature History

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Previous Names: cyp17 (1), P450c17 (1), wu:fi13g04, wu:fi17b11, wu:fi31c08, zgc:136516, zgc:66494

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; 17-alpha-hydroxyprogesterone aldolase activity; and steroid 17-alpha-monooxygenase activity. Involved in several processes, including androst-4-ene-3,17-dione biosynthetic process; female sex determination; and progesterone metabolic process. Is expressed in Leydig cell; brain; and gonad. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1).
Genome Resources: Alliance (1),  Gene:399692 (1),  Ensembl(GRCz11):ENSDARG00000033566 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a259 Small Deletion Unknown Unknown
ihb144 Small Deletion Unknown Unknown TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa7373 Point Mutation Unknown Missense ENU
    sa22316 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35505 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cyp17a1 1
    CRISPR2-cyp17a1 1
    CRISPR3-cyp17a1 1
    CRISPR4-cyp17a1 1
    MO1-cyp17a1 N/A 1
    DISEASE ASSOCIATED WITH cyp17a1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital adrenal hyperplasia Alliance 17,20-lyase deficiency, isolated 202110
    17-alpha-hydroxylase/17,20-lyase deficiency 202110
    DISEASE ASSOCIATED WITH cyp17a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process androst-4-ene-3,17-dione biosynthetic process (more)
    Cellular Component membrane (more)
    Molecular Function 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp17a1-201 (1)    Ensembl 2799
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cyp17a1 Rabbit IHC 3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp17a1 No data available
    MARKER RELATIONSHIPS
    cyp17a1 Contained in: [BAC] CH211-67N3 (1)
    cyp17a1 Contains: [SNP] rs3728563 (1), rs3728564 (1), rs3728565 (1)
    cyp17a1 Encodes: [EST] fi13g04, fi17b11, fi31c08, IMAGE:7157435 (1)
    [cDNA] MGC:66494 (1), MGC:136516 (1), MGC:194068 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212806 (1) 2794 nt
    Genomic GenBank:AL928951 (1) 183050 nt
    Select Tool
    Polypeptide UniProtKB:A2ATX9 (1) 519 aa
    Sequence Information (all 35)
    ORTHOLOGY for cyp17a1 ( Chr: 13 )
    CITATIONS (159)