Gene
lhcgr
- ID
- ZDB-GENE-040806-3
- Name
- luteinizing hormone/choriogonadotropin receptor
- Symbol
- lhcgr Nomenclature History
- Previous Names
-
- lhr
- GTHR-II
- zfGTHR-II
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Exhibits luteinizing hormone receptor activity. Involved in gamete generation and gonad development. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Is expressed in digestive system; gonad; and hypophysis. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial male-limited precocious puberty | Alliance | Leydig cell adenoma, somatic, with precocious puberty | 176410 |
| familial male-limited precocious puberty | Alliance | Precocious puberty, male | 176410 |
| Leydig cell hypoplasia type I | Alliance | Leydig cell hypoplasia with hypergonadotropic hypogonadism | 238320 |
| Leydig cell hypoplasia type I | Alliance | Leydig cell hypoplasia with pseudohermaphroditism | 238320 |
| Leydig cell hypoplasia type I | Alliance | Luteinizing hormone resistance, female | 238320 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR017452 | GPCR, rhodopsin-like, 7TM |
| Family | IPR000276 | G protein-coupled receptor, rhodopsin-like |
| Family | IPR002131 | Glycoprotein hormone receptor family |
| Family | IPR002273 | Lutropin-choriogonadotropic hormone receptor |
| Family | IPR002274 | Thyrotropin receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR026906 | BspA-type LRR region |
Domain Details Per Protein
| Protein | Length | BspA-type LRR region | Glycoprotein hormone receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Leucine-rich repeat domain superfamily | Lutropin-choriogonadotropic hormone receptor | Thyrotropin receptor |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6TCF8
|
708 | |||||||
|
UniProtKB:A0A8M9QNC1
|
683 |
Interactions and Pathways
No data available
Plasmids
No data available