Gene
hsd11b2
- ID
- ZDB-GENE-030131-6030
- Name
- hydroxysteroid (11-beta) dehydrogenase 2
- Symbol
- hsd11b2 Nomenclature History
- Previous Names
-
- wu:fi31d01
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity. Acts upstream of or within cortisol metabolic process and multicellular organismal response to stress. Predicted to be located in membrane. Is expressed in several structures, including brain; cardiovascular system; digestive system; endocrine system; and eye. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77132 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Theodoridi et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| apparent mineralocorticoid excess syndrome | Alliance | Apparent mineralocorticoid excess | 218030 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NAD(P)-binding domain superfamily | Short-chain dehydrogenase/reductase, conserved site | Short-chain dehydrogenase/reductase SDR |
|---|---|---|---|---|---|
| UniProtKB:F1QLP1 | InterPro | 414 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hsd11b2-201
(1)
|
Ensembl | 2,592 nt |
Interactions and Pathways
No data available
Plasmids
No data available