Gene
hsd11b2
- ID
- ZDB-GENE-030131-6030
- Name
- hydroxysteroid (11-beta) dehydrogenase 2
- Symbol
- hsd11b2 Nomenclature History
- Previous Names
-
- wu:fi31d01
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity. Involved in cortisol metabolic process and multicellular organismal response to stress. Predicted to localize to integral component of membrane. Is expressed in several structures, including brain; cardiovascular system; digestive system; eye; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2).
- Genome Resources
- Note
- None
- All Expression Data
- 25 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
- Thisse Expression Data
-
- MGC:77132 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
apparent mineralocorticoid excess syndrome | Alliance | Apparent mineralocorticoid excess | 218030 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | NAD(P)-binding domain superfamily | Short-chain dehydrogenase/reductase, conserved site | Short-chain dehydrogenase/reductase SDR |
---|---|---|---|---|
UniProtKB:Q6P0H9
|
400 | |||
UniProtKB:F1QLP1
|
414 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
hsd11b2-201
(1)
|
2592 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl