Gene

hsd11b2

ID

ZDB-GENE-030131-6030

Name

hydroxysteroid (11-beta) dehydrogenase 2

Symbol

hsd11b2 Nomenclature History

Previous Names

wu:fi31d01

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity. Involved in cortisol metabolic process and multicellular organismal response to stress. Predicted to localize to integral component of membrane. Is expressed in several structures, including brain; cardiovascular system; digestive system; eye; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2).

Genome Resources

Note

None

Expression

All Expression Data

25 figures from 16 publications

Cross-Species Comparison

High Throughput Data

No data available

Thisse Expression Data

MGC:77132 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hsd11b2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
apparent mineralocorticoid excess syndrome	Alliance	Apparent mineralocorticoid excess	218030

Associated With hsd11b2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020904	Short-chain dehydrogenase/reductase, conserved site
Family	IPR002347	Short-chain dehydrogenase/reductase SDR
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily