Gene

hsd11b2

ID
ZDB-GENE-030131-6030
Name
hydroxysteroid (11-beta) dehydrogenase 2
Symbol
hsd11b2 Nomenclature History
Previous Names
  • wu:fi31d01
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity. Involved in cortisol metabolic process and multicellular organismal response to stress. Predicted to localize to integral component of membrane. Is expressed in several structures, including brain; cardiovascular system; digestive system; eye; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2).
Genome Resources
Note
None
Expression
All Expression Data
25 figures from 16 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hsd11b2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
apparent mineralocorticoid excess syndrome Alliance Apparent mineralocorticoid excess 218030
Associated With hsd11b2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020904 Short-chain dehydrogenase/reductase, conserved site
Family IPR002347 Short-chain dehydrogenase/reductase SDR
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length NAD(P)-binding domain superfamily Short-chain dehydrogenase/reductase, conserved site Short-chain dehydrogenase/reductase SDR
UniProtKB:Q6P0H9 400
UniProtKB:F1QLP1 414
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations