Gene
cyp19a1a
- ID
- ZDB-GENE-990415-43
- Name
- cytochrome P450, family 19, subfamily A, polypeptide 1a
- Symbol
- cyp19a1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Acts upstream of with a positive effect on ovarian follicle development. Acts upstream of or within several processes, including primary sex determination, germ-line; regulation of estrogen biosynthetic process; and response to estradiol. Predicted to be located in membrane. Is expressed in several structures, including endocrine system; eye; female organism; male organism; and reproductive system. Used to study disorder of sexual development. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 87 figures from 61 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Aromatase deficiency | 613546 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| disorder of sexual development | cyp19a1azf1031/zf1031 (AB) | standard conditions | Yin et al., 2017 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 Monooxygenases | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:O42145
|
509 | |||||
|
UniProtKB:Q1LV36
|
517 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp19a1a-201
(1)
|
Ensembl | 1,862 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB2-cyp19a1a | polyclonal | Rabbit |
|
1 | |||
| Ab1-cyp19a1a | polyclonal | IgG | Rabbit |
|
AnaSpec
|
4 |
Plasmids
No data available