Gene
fshr
- ID
- ZDB-GENE-020423-5
- Name
- follicle stimulating hormone receptor
- Symbol
- fshr Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Exhibits follicle-stimulating hormone receptor activity. Involved in male gonad development; ovarian follicle development; and spermatogenesis. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Is expressed in Leydig cell; gonad; and kidney. Orthologous to human FSHR (follicle stimulating hormone receptor).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 23 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu86 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
ovarian dysgenesis 1 | Alliance | Ovarian dysgenesis 1 | 233300 |
ovarian hyperstimulation syndrome | Alliance | Ovarian hyperstimulation syndrome | 608115 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR017452 | GPCR, rhodopsin-like, 7TM |
Family | IPR000276 | G protein-coupled receptor, rhodopsin-like |
Family | IPR002131 | Glycoprotein hormone receptor family |
Family | IPR002274 | Thyrotropin receptor |
Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
Repeat | IPR001611 | Leucine-rich repeat |
Repeat | IPR026906 | BspA-type LRR region |
Domain Details Per Protein
Protein | Length | BspA-type LRR region | Glycoprotein hormone receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Thyrotropin receptor |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q6TCF9
|
668 |
Interactions and Pathways
No data available
Plasmids