Gene
esr2b
- ID
- ZDB-GENE-030116-1
- Name
- estrogen receptor 2b
- Symbol
- esr2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables estradiol binding activity; nuclear estrogen receptor activity; and steroid hormone binding activity. Involved in sex determination. Acts upstream of or within response to estrogen. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including forebrain; head; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103724 (1 image)
- aj414566 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa77 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uab127 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| ulg079 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| umo13 | Allele with one deletion | Exon 1 | Premature Stop | CRISPR | |
| zf3760 | unknown | Unknown | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-esr2b | (4) | |
| CRISPR2-esr2b | (3) | |
| CRISPR3-esr2b | (2) | |
| MO1-esr2b | N/A | (4) |
| MO2-esr2b | N/A | (6) |
| MO3-esr2b | N/A | Bugel et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ovarian dysgenesis 8 | Alliance | ?Ovarian dysgenesis 8 | 618187 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR021064 | Estrogen receptor beta-like, N-terminal |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR024178 | Estrogen receptor/oestrogen-related receptor |
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Domain Details Per Protein
| Protein | Length | Estrogen receptor beta/gamma | Estrogen receptor beta-like, N-terminal | Estrogen receptor/oestrogen-related receptor | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B359
|
600 | |||||||||
|
UniProtKB:Q5PR29
|
592 | |||||||||
|
UniProtKB:B8JJL3
|
592 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(esr2b:EGFP) |
|
| 1 | Wang et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-249P9 | ZFIN Curated Data | |
| Encodes | EST | aj414566 | Bertrand et al., 2007 | |
| Encodes | cDNA | MGC:103724 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191967 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_174862 (1) | 2718 nt | ||
| Genomic | GenBank:CT025749 (1) | 188450 nt | ||
| Polypeptide | UniProtKB:A0A8M2B359 (1) | 600 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | ESR2 | 14 | Phylogenetic tree (1) Amino acid sequence comparison (4) Conserved genome location (synteny) (1) Nucleotide sequence comparison (1) | |
| Mouse | Esr2 | 12 | Phylogenetic tree (1) Nucleotide sequence comparison (1) Amino acid sequence comparison (3) Conserved genome location (synteny) (1) |
- Ai, N., Han, C.R., Zhao, H., Cheng, S.Y., Ge, W. (2024) Disruption of thyroid hormone receptor thrab leads to female infertility in zebrafish. Endocrinology. 165(5):
- Guerrero-Limón, G., Muller, M. (2024) Exploring Estrogen antagonism using CRISPR/Cas9 to generate specific mutants for each of the receptors. Chemosphere. 364:143100
- Peng, W., Zhang, Y., Song, B., Yang, P., Liu, L. (2024) Developmental Delay and Male-Biased Sex Ratio in esr2b Knockout Zebrafish. Genes. 15(5):
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Shaw, K., Lu, C., Liu, X., Trudeau, V.L. (2023) Arginine vasopressin injection rescues delayed oviposition in cyp19a1b-/- mutant female zebrafish. Frontiers in endocrinology. 14:13086751308675
- Wesselman, H.M., Gatz, A.E., Pfaff, M.R., Arceri, L., Wingert, R.A. (2023) Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney. Cells. 12(4):
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Boland, R., Heemskerk, M.T., Forn-Cuní, G., Korbee, C.J., Walburg, K.V., Esselink, J.J., Carvalho Dos Santos, C., de Waal, A.M., van der Hoeven, D.C.M., van der Sar, E., de Ries, A.S., Xie, J., Spaink, H.P., van der Vaart, M., Haks, M.C., Meijer, A.H., Ottenhoff, T.H.M. (2022) Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis. mBio. 14(1):e0302422
- Chen, X., Zheng, J., Zhang, J., Duan, M., Xu, H., Zhao, W., Yang, Y., Wang, C., Xu, Y. (2022) Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior. The Science of the total environment. 838(Pt 1):155610
- Duan, M., Guo, X., Chen, X., Guo, M., Xu, H., Hao, L., Wang, C., Yang, Y. (2022) Life Cycle Exposure to Cyhalofop-Butyl Induced Reproductive Toxicity in Zebrafish. Toxics. 10(9)
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