Gene
piwil1
- ID
- ZDB-GENE-030813-2
- Name
- piwi-like RNA-mediated gene silencing 1
- Symbol
- piwil1 Nomenclature History
- Previous Names
-
- ziwi (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables piRNA binding activity. Involved in anatomical structure morphogenesis; germ cell development; and piRNA processing. Located in P granule. Is expressed in several structures, including blastodisc; central nervous system; eye; reproductive system; and unfertilized egg. Orthologous to several human genes including PIWIL1 (piwi like RNA-mediated gene silencing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Houwing et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh219 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| fh220 | Allele with one point mutation | Unknown | Unknown | ENU | |
| fh221 | Allele with one point mutation | Unknown | Unknown | ENU | |
| hu2410 | Allele with one point mutation | Unknown | Unknown | ENU | |
| hu2479 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la016400Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026576Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| piwil1_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa7619 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa8531 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GAGE | PAZ domain | PAZ domain superfamily | Piwi domain | Ribonuclease H-like superfamily | Ribonuclease H superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8UVX0 | InterPro | 858 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
piwil1-201
(1)
|
Ensembl | 3,206 nt | ||
| mRNA |
piwil1-203
(1)
|
Ensembl | 549 nt | ||
| mRNA |
piwil1-204
(1)
|
Ensembl | 762 nt | ||
| mRNA |
piwil1-205
(1)
|
Ensembl | 3,257 nt | ||
| mRNA |
piwil1-206
(1)
|
Ensembl | 915 nt | ||
| ncRNA |
piwil1-006
(1)
|
Ensembl | 898 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-piwil1 | polyclonal | Rabbit |
|
1 | |||
| Ab5-piwil1 | polyclonal | Rabbit |
|
3 | |||
| AB4-piwil1 | polyclonal | Rabbit |
|
2 | |||
| Ab1-piwil1 | polyclonal | Rabbit |
|
6 |
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-308B14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-245G2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_183338 (1) | 3258 nt | ||
| Genomic | GenBank:CR450819 (1) | 168244 nt | ||
| Polypeptide | UniProtKB:Q8UVX0 (1) | 858 aa |
- Wilson, M.L., Romano, S.N., Khatri, N., Aharon, D., Liu, Y., Kaufman, O.H., Draper, B.W., Marlow, F.L. (2024) Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios. Nature communications. 15:52485248
- Zanardini, M., Zhang, W., Habibi, H.R. (2024) Arginine Vasotocin Directly Regulates Spermatogenesis in Adult Zebrafish (Danio rerio) Testes. International Journal of Molecular Sciences. 25(12):
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Islam, K.N., Ajao, A., Venkataramani, K., Rivera, J., Pathania, S., Henke, K., Siegfried, K.R. (2023) The RNA-binding protein Adad1 is necessary for germ cell maintenance and meiosis in zebrafish. PLoS Genetics. 19:e1010589e1010589
- Wang, X., Zhu, J., Wang, H., Deng, W., Jiao, S., Wang, Y., He, M., Zhang, F., Liu, T., Hao, Y., Ye, D., Sun, Y. (2023) Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Nature communications. 14:79187918
- Ye, D., Liu, T., Li, Y., Wang, Y., Hu, W., Zhu, Z., Sun, Y. (2023) Identification of fish spermatogenic cells through high-throughput immunofluorescence against testis with an antibody set. Frontiers in endocrinology. 14:10443181044318
- Jamieson-Lucy, A.H., Kobayashi, M., James Aykit, Y., Elkouby, Y., Escobar-Aguirre, M., Vejnar, C., Giraldez, A., Mullins, M.C. (2022) A proteomics approach identifies novel resident zebrafish Balbiani body proteins Cirbpa and Cirbpb. Developmental Biology. 484:1-11
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Bertho, S., Kaufman, O., Lee, K., Santos-Ledo, A., Dellal, D., Marlow, F.L. (2021) A transgenic system for targeted ablation of reproductive and maternal-effect genes. Development (Cambridge, England). 148(12):
- Dai, X., Cheng, X., Huang, J., Gao, Y., Wang, D., Feng, Z., Zhai, G., Lou, Q., He, J., Wang, Z., Yin, Z. (2021) Rbm46, a novel germ cell specific factor, modulates meiotic progression and spermatogenesis. Biology of reproduction. 104(5):1139-1153
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