Gene

cyp11a1

ID
ZDB-GENE-010306-1
Name
cytochrome P450, family 11, subfamily A, polypeptide 1
Symbol
cyp11a1 Nomenclature History
Previous Names
  • cb957 (1)
  • P450scc (1)
  • scc (1)
  • side-chain cleavage enzyme (1)
  • wu:fj97d10
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including C21-steroid hormone biosynthetic process; epiboly; and positive regulation of microtubule polymerization. Predicted to localize to mitochondrial inner membrane. Is expressed in brain; endocrine system; female organism; interrenal primordium; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
46 figures from 28 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyp11a1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital adrenal insufficiency Alliance Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete 613743
Associated With cyp11a1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017972 Cytochrome P450, conserved site
Family IPR001128 Cytochrome P450
Family IPR002399 Cytochrome P450, mitochondrial
Family IPR002401 Cytochrome P450, E-class, group I
Family IPR033283 Cholesterol side-chain cleavage enzyme, mitochondrial
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
Domain Details Per Protein
Protein Length Cholesterol side-chain cleavage enzyme, mitochondrial Cytochrome P450 Cytochrome P450, conserved site Cytochrome P450, E-class, group I Cytochrome P450, mitochondrial Cytochrome P450 superfamily
UniProtKB:X1WFM9 235
UniProtKB:X1WH33 266
UniProtKB:Q7SYJ6 509
UniProtKB:Q8JH93 509
UniProtKB:A8KC03 509
UniProtKB:X1WBB6 245
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations