Gene
amh
- ID
- ZDB-GENE-050706-192
- Name
- anti-Mullerian hormone
- Symbol
- amh Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity. Acts upstream of or within several processes, including negative regulation of androgen secretion; regulation of ovarian follicle development; and sperm capacitation. Predicted to be located in extracellular region. Is expressed in female organism; granulosa cell; male organism; and reproductive system. Human ortholog(s) of this gene implicated in disorder of sexual development; ovarian carcinoma; and persistent Mullerian duct syndrome. Orthologous to human AMH (anti-Mullerian hormone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 68 figures from 51 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1373 | Allele with one delins | Unknown | Unknown | CRISPR | |
| b1374 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| b1375 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb361 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb397 | Allele with one deletion | Exon 6 | Frameshift, Premature Stop | CRISPR | |
| ihb398 | Allele with one insertion | Exon 6 | Frameshift, Premature Stop | CRISPR | |
| sa24159 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uc28 | Allele with one deletion | Unknown | Unknown | TALEN | |
| umo17 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-amh | Lin et al., 2017 | |
| CRISPR2-amh | (2) | |
| CRISPR3-amh | Yan et al., 2019 | |
| CRISPR4-amh | (3) | |
| TALEN1-amh | Yan et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| persistent Mullerian duct syndrome | Alliance | Persistent Mullerian duct syndrome, type I | 261550 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Anti-Mullerian hormone, N-terminal | Cystine-knot cytokine | Muellerian-inhibiting factor | Transforming growth factor-beta, C-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:A8E7B8 | InterPro | 549 | ||||
| UniProtKB:Q6B6Q2 | InterPro | 549 |
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Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-211F22 | von Hofsten et al., 2005 | |
| Encodes | EST | fo84g06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007779 (1) | 1650 nt | ||
| Genomic | GenBank:BX005098 (2) | 100658 nt | ||
| Polypeptide | UniProtKB:A8E7B8 (1) | 549 aa |
- Ruan, Y., Li, X., Zhai, G., Lou, Q., Jin, X., He, J., Yin, Z. (2024) Estrogen Signaling Inhibits the Expression of anti-Müllerian hormone (amh) and gonadal-soma-derived factor (gsdf) during the Critical Time of Sexual Fate Determination in Zebrafish. International Journal of Molecular Sciences. 25(3):
- Chu, W.K., Huang, S.C., Chang, C.F., Wu, J.L., Gong, H.Y. (2023) Infertility control of transgenic fluorescent zebrafish with targeted mutagenesis of the dnd1 gene by CRISPR/Cas9 genome editing. Frontiers in genetics. 14:10292001029200
- Colella, M., Cuomo, D., Nittoli, V., Amoresano, A., Porciello, A., Reale, C., Roberto, L., Russo, F., Russo, N.A., De Felice, M., Mallardo, M., Ambrosino, C. (2023) A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging. International Journal of Molecular Sciences. 24(3):
- Liao, X., Tao, B., Zhang, X., Chen, L., Chen, J., Song, Y., Hu, W. (2023) Loss of gdnfa disrupts spermiogenesis and male courtship behavior in zebrafish. Molecular and Cellular Endocrinology. 576:112010
- Wang, X., Zhu, J., Wang, H., Deng, W., Jiao, S., Wang, Y., He, M., Zhang, F., Liu, T., Hao, Y., Ye, D., Sun, Y. (2023) Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Nature communications. 14:79187918
- Doretto, L.B., Butzge, A.J., Nakajima, R.T., Martinez, E.R.M., de Souza, B.M., Rodrigues, M.D.S., Rosa, I.F., Ricci, J.M.B., Tovo-Neto, A., Costa, D.F., Malafaia, G., Shao, C., Nóbrega, R.H. (2022) Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Cells. 11(8):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Rodrigues, M.S., Tovo-Neto, A., Rosa, I.F., Doretto, L.B., Fallah, H.P., Habibi, H.R., Nóbrega, R.H. (2022) Thyroid Hormones Deficiency Impairs Male Germ Cell Development: A Cross Talk Between Hypothalamic-Pituitary-Thyroid, and-Gonadal Axes in Zebrafish. Frontiers in cell and developmental biology. 10:865948
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Valdivieso, A., Anastasiadi, D., Ribas, L., Piferrer, F. (2022) Development of epigenetic biomarkers for the identification of sex and thermal stress in fish using DNA methylation analysis and machine learning procedures. Molecular Ecology Resources. 23(2):453-470
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