Lam et al., 2011 - Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. BMC Medical Genomics   4(1):41 Full text @ BMC Med. Genomics

Fig. 1

Expression profile of zebrafish estrogen-responsive genes. A. Total of 1092 estrogen-responsive genes (715 up-regulated and 377 down-regulated) following E2 treatment which are also partially suppressed or normalized in E2+ICI treatment. B. Selected estrogen-responsive genes having their estrogen-induced transcriptional changes almost completely suppressed or normalized by E2+ICI treatment. C. Selected estrogen-responsive genes having their estrogen-induced transcriptional changes partially suppressed by E2+ICI treatment.

Fig. 2

Validation of microarray data by qRT-PCR. A. Expression levels of vtg1 and vtg3 and B. esr1. C. Selection of representative up-regulated genes. D. Selection of representative down-regulated genes. The data represents average of 3 replicates and presented as mean and standard deviation.

Acknowledgments:
ZFIN wishes to thank the journal BMC Medical Genomics for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ BMC Med. Genomics