ZFIN ID: ZDB-GENE-051113-124
Gene Name: doublecortin domain containing 2B
Gene Symbol: dcdc2b    Nomenclature History

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Previous Name: zgc:123267

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Involved in pronephros development; sensory organ development; and sensory perception of sound. Predicted to colocalize with cortical actin cytoskeleton. Is expressed in otic vesicle. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autosomal recessive nonsyndromic deafness 66; dyslexia; nephronophthisis 19; and sclerosing cholangitis. Orthologous to several human genes including DCDC2B (doublecortin domain containing 2B).
Genome Resources: Alliance (1),  Gene:563259 (1),  Ensembl(GRCz11):ENSDARG00000053744 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1463 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42243 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dcdc2b N/A 1
    MO2-dcdc2b N/A 1
    MO3-dcdc2b N/A 1
    DISEASE ASSOCIATED WITH dcdc2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dcdc2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neuromast hair cell development (more)
    Cellular Component COLOCALIZES_WITH   cortical actin cytoskeleton (more)
    Molecular Function molecular_function (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dcdc2b-201 (1)    Ensembl 1712
    dcdc2b-202 (1)    Ensembl 640
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dcdc2b No data available
    MARKER RELATIONSHIPS
    dcdc2b Contained in: [BAC] DKEY-71P21 (1) (order this)
    dcdc2b Encodes: [cDNA] MGC:123267 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001037689 (1) 1720 nt
    Genomic GenBank:BX284673 (1) 171564 nt
    Select Tool
    Polypeptide UniProtKB:Q32PM1 (1) 448 aa
    Sequence Information (all 27)
    ORTHOLOGY for dcdc2b ( Chr: 13 )
    CITATIONS (23)