ZFIN ID: ZDB-GENE-980526-437
Gene Name: T-box transcription factor Ta
Gene Symbol: tbxta    Nomenclature History

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Previous Names: T, ta, ZF-T (1), zft, brachyury, cb240 (1), id:ibd5074 (1), no tail a, ntl, ntla, wu:fc80a01 (1), ZF-NTL (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including Kupffer's vesicle development; animal organ development; and regulation of embryonic development. Localizes to nuclear chromatin. Is expressed in several structures, including blastoderm; germ ring; mesoderm; presumptive structure; and tail bud. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T).
Genome Resources: Alliance (1),  Gene:30399 (1),  Ensembl(GRCz11):ENSDARG00000101576 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b160 Insertion Unknown Unknown G_RAYS
b195 Insertion Unknown Unknown SPONTANEOUS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • b459 Unknown Unknown Unknown
    b487 Unknown Unknown Unknown
    kt338 Unknown Unknown Unknown
    kt501a Unknown Unknown Unknown
    kt633 Unknown Unknown Unknown
    m147 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m550 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13983 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tb244e Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tbxta_unspecified Unspecified Unknown Unknown
    tc41 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ts260 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • w181 Complex Unknown Unknown SPONTANEOUS
    PHENOTYPE
    Data: 51 figures from 34 publications
    Observed in:
    DISEASE ASSOCIATED WITH tbxta HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Sacral agenesis with vertebral anomalies 615709
    {Neural tube defects, susceptibility to} 182940
    DISEASE ASSOCIATED WITH tbxta VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in axis elongation (more)
    Cellular Component nuclear chromatin (more)
    Molecular Function DNA binding (more)
    GO Terms (all 41)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbxta-201 (1)    Ensembl 2211
    ncRNA ta-002 (1)    Ensembl 851
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ta polyclonal Rabbit IHC 40
    AB3-ta monoclonal IgG1 Mouse 2
    Ab2-ta monoclonal Mouse 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbxta
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1tbxta:CFP) tbxta CFP Danio rerio 1 3
    Tg(HSE:ntla-MYC,EGFP) EGFPtbxta Danio rerio 1 4
    Tg(ntla:GAL4-VP16) tbxta GAL4VP16 Danio rerio 1 3
    Tg(tbxta:Kaede) tbxta Kaede Danio rerio 1 1
    Tg(tbxta:LY-Tomato) tbxta LYTomato Danio rerio 1 3
    tg(tbxta:mcherry-2a-cre) tbxta 2ACremCherry Danio rerio 1 1
    TgBAC(tbxta:tbxta-FLAG) tbxta tbxta Danio rerio 1 2
    MARKER RELATIONSHIPS
    tbxta Contained in: [BAC] CH73-285B23 (1)
    tbxta Encodes: [EST] cb240 (1), fc80a01 (1), ibd5074 (1)
    [cDNA] MGC:193897 (1), MGC:193903 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131162 (1) 2238 nt
    Genomic GenBank:CU633985 (1) 108421 nt
    Select Tool
    Polypeptide UniProtKB:Q07998 (1) 423 aa
    Sequence Information (all 23)
    ORTHOLOGY for tbxta ( Chr: 19 )
    CITATIONS (837)