Gene

mmp9

ID
ZDB-GENE-040426-2132
Name
matrix metallopeptidase 9
Symbol
mmp9 Nomenclature History
Previous Names
  • fj05a08
  • gelatinase B (1)
  • wu:fb02g06 (1)
  • wu:fb07b05 (1)
  • wu:fi98c09 (1)
  • wu:fj05a08 (1)
  • zgc:64165
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity. Involved in several processes, including collagen fibril organization; fin regeneration; and positive regulation of granuloma formation. Predicted to localize to extracellular space. Is expressed in several structures, including cardiovascular system; female organism; head; hematopoietic cell; and hematopoietic system. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune hypersensitivity disease (multiple); and lung disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9).
Genome Resources
Note
None
Expression
All Expression Data
103 figures from 73 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mmp9 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Metaphyseal anadysplasia 2 613073
Associated With mmp9 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021158 Peptidase M10A, cysteine switch, zinc binding site
Domain IPR000562 Fibronectin type II domain
Domain IPR000585 Hemopexin-like domain
Domain IPR001818 Peptidase M10, metallopeptidase
Domain IPR002477 Peptidoglycan binding-like
Domain IPR006026 Peptidase, metallopeptidase
Domain IPR033739 Peptidase M10A, catalytic domain
Family IPR021190 Peptidase M10A
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036365 PGBD-like superfamily
Homologous_superfamily IPR036366 PGBD superfamily
Homologous_superfamily IPR036375 Hemopexin-like domain superfamily
Homologous_superfamily IPR036943 Fibronectin type II domain superfamily
Repeat IPR018487 Hemopexin-like repeats
Domain Details Per Protein
Protein Length Fibronectin type II domain Fibronectin type II domain superfamily Hemopexin-like domain Hemopexin-like domain superfamily Hemopexin-like repeats Kringle-like fold Metallopeptidase, catalytic domain superfamily Peptidase M10A Peptidase M10A, catalytic domain Peptidase M10A, cysteine switch, zinc binding site Peptidase M10, metallopeptidase Peptidase, metallopeptidase Peptidoglycan binding-like PGBD-like superfamily PGBD superfamily
UniProtKB:Q7T317 680
UniProtKB:F8QXP1 310
UniProtKB:F1QC76 680
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations