Gene
mmp9
- ID
- ZDB-GENE-040426-2132
- Name
- matrix metallopeptidase 9
- Symbol
- mmp9 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Involved in positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including collagen fibril organization; fin regeneration; and positive regulation of granuloma formation. Predicted to be located in extracellular matrix and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; female organism; hematopoietic cell; hematopoietic system; and muscle. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 154 figures from 111 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64165 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Metaphyseal anadysplasia 2 | 613073 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR021158 | Peptidase M10A, cysteine switch, zinc binding site |
| Domain | IPR000562 | Fibronectin type II domain |
| Domain | IPR000585 | Hemopexin-like domain |
| Domain | IPR001818 | Peptidase M10, metallopeptidase |
| Domain | IPR006026 | Peptidase, metallopeptidase |
| Domain | IPR033739 | Peptidase M10A, catalytic domain |
| Family | IPR021190 | Peptidase M10A |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036365 | PGBD-like superfamily |
| Homologous_superfamily | IPR036375 | Hemopexin-like domain superfamily |
| Homologous_superfamily | IPR036943 | Fibronectin type II domain superfamily |
| Repeat | IPR018487 | Hemopexin-like repeats |
Domain Details Per Protein
| Protein | Length | Fibronectin type II domain | Fibronectin type II domain superfamily | Hemopexin-like domain | Hemopexin-like domain superfamily | Hemopexin-like repeats | Kringle-like fold | Metallopeptidase, catalytic domain superfamily | Peptidase M10A | Peptidase M10A, catalytic domain | Peptidase M10A, cysteine switch, zinc binding site | Peptidase M10, metallopeptidase | Peptidase, metallopeptidase | PGBD-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T317
|
680 |
Interactions and Pathways
No data available
Plasmids
No data available