Gene

tph1a

ID
ZDB-GENE-030317-1
Name
tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a
Symbol
tph1a Nomenclature History
Previous Names
  • tph1-1 (1)
  • tph1
  • tph
  • tphD1
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have tryptophan 5-monooxygenase activity. Involved in regulation of hematopoietic stem cell differentiation. Predicted to localize to neuron projection. Is expressed in nervous system; neural tube; and ovary. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; mental depression (multiple); and scoliosis. Orthologous to human TPH1 (tryptophan hydroxylase 1).
Genome Resources
Note
None
Expression
All Expression Data
25 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tph1a Human Ortholog
No data available
Associated With tph1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018301 Aromatic amino acid hydroxylase, iron/copper binding site
Domain IPR002912 ACT domain
Domain IPR019774 Aromatic amino acid hydroxylase, C-terminal
Domain IPR041904 Tryptophan 5-hydroxylase, catalytic domain
Family IPR001273 Aromatic amino acid hydroxylase
Family IPR005963 Tryptophan 5-monooxygenase
Family IPR019773 Tyrosine 3-monooxygenase-like
Homologous_superfamily IPR036329 Aromatic amino acid monoxygenase, C-terminal domain superfamily
Homologous_superfamily IPR036951 Aromatic amino acid hydroxylase superfamily
Domain Details Per Protein
Protein Length ACT domain Aromatic amino acid hydroxylase Aromatic amino acid hydroxylase, C-terminal Aromatic amino acid hydroxylase, iron/copper binding site Aromatic amino acid hydroxylase superfamily Aromatic amino acid monoxygenase, C-terminal domain superfamily Tryptophan 5-hydroxylase, catalytic domain Tryptophan 5-monooxygenase Tyrosine 3-monooxygenase-like
UniProtKB:Q8AY71 471
UniProtKB:Q6PBX4 483
UniProtKB:F1R1D3 483
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations