Gene
tph1a
- ID
- ZDB-GENE-030317-1
- Name
- tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a
- Symbol
- tph1a Nomenclature History
- Previous Names
-
- tph1-1 (1)
- tph1
- tph
- tphD1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation and response to hypoxia. Predicted to be active in neuron projection. Is expressed in nervous system; neural tube; and ovary. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and heroin dependence. Orthologous to human TPH1 (tryptophan hydroxylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73202 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
| Domain | IPR002912 | ACT domain |
| Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
| Domain | IPR041904 | Tryptophan 5-hydroxylase, catalytic domain |
| Family | IPR001273 | Aromatic amino acid hydroxylase |
| Family | IPR005963 | Tryptophan 5-monooxygenase |
| Family | IPR019773 | Tyrosine 3-monooxygenase-like |
| Homologous_superfamily | IPR036329 | Aromatic amino acid monoxygenase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036951 | Aromatic amino acid hydroxylase superfamily |
| Homologous_superfamily | IPR045865 | ACT-like domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | ACT domain | ACT-like domain | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tryptophan 5-hydroxylase, catalytic domain | Tryptophan 5-monooxygenase | Tyrosine 3-monooxygenase-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YYD4 | InterPro | 477 | ||||||||||
| UniProtKB:Q6PBX4 | InterPro | 483 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids