Gene

svila

ID
ZDB-GENE-990706-5
Name
supervillin a
Symbol
svila Nomenclature History
Previous Names
  • svil
  • sb:cb867
  • wu:fd05a09
  • zmp:0000000648 (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within cytoskeleton organization. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including adaxial cell; cardiovascular system; musculature system; optic vesicle; and sensory system. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Deo et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With svila Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
myofibrillar myopathy 10 Alliance Myofibrillar myopathy 10 619040
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Associated With svila Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003128 Villin headpiece
Domain IPR007123 Gelsolin-like domain
Family IPR007122 Villin/Gelsolin
Homologous_superfamily IPR029006 ADF-H/Gelsolin-like domain superfamily
Homologous_superfamily IPR036886 Villin headpiece domain superfamily
1 - 5 of 5
Domain Details Per Protein
Protein Additional Resources Length ADF-H/Gelsolin-like domain superfamily Gelsolin-like domain Villin/Gelsolin Villin headpiece Villin headpiece domain superfamily
UniProtKB:A0A8M9Q864 InterPro 2239
UniProtKB:A0A8M9QII8 InterPro 2264
UniProtKB:A0A8M9QE30 InterPro 2208
UniProtKB:A0A8M9PW23 InterPro 2241
UniProtKB:A0A8M9QIJ4 InterPro 1847
1 - 5 of 10 Show all
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
aberrant processed transcript svila-207 (1)
Ensembl
Ensembl 750 nt
ZFIN BLAST
mRNA svila-201 (1)
Ensembl
Ensembl 6,407 nt
ZFIN BLAST
mRNA svila-202 (1)
Ensembl
Ensembl 511 nt
ZFIN BLAST
mRNA svila-203 (1)
Ensembl
Ensembl 2,851 nt
ZFIN BLAST
mRNA svila-204 (1)
Ensembl
Ensembl 553 nt
ZFIN BLAST
1 - 5 of 9 Show all
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations
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