FIGURE

Fig. 5

ID

ZDB-FIG-110622-123

Publication

Lupo et al., 2011 - Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme

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Fig. 5

Exogenous RA activates genes expressed in the VR/OS and in POM. (A and B) Lateral views of eyes from 31-hpf hybridized embryos treated with DMSO or 1 μM RA from 18s. (A) Arrowheads point at the expression of vax1, dact1, nlz2, and itgA5 in the VR/OS. RA treatment reduces vax1 expression in the VR/OS while inducing it ectopically in the dorsal telencephalon (triangle) and diencephalon (arrow). The RA-treated embryos show dact1 and nlz2 expression throughout the retina and ectopic itgA5 expression in the dorsal retina (triangle). (B) RA treatment increases foxC1a, nlz1, lmx1b1, and pitx2 expression in anterior-ventral (arrowheads) and/or anterior-dorsal (triangles) POM. Approximately 20 embryos for each condition and probe were used for these analyses.

Expression Data

Genes:	dact1 foxc1a itga5 lmx1bb pitx2 vax1 znf503 znf703
Fish:	WT
Condition:	chemical treatment: all-trans-retinoic acid
Anatomical Terms:	diencephalon optic stalk periocular mesenchyme retina retina dorsal region retina ventral region telencephalon dorsal region
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA