Gene
znf503
- ID
- ZDB-GENE-031113-5
- Name
- zinc finger protein 503
- Symbol
- znf503 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within embryonic camera-type eye morphogenesis and hindbrain development. Located in nucleus. Is expressed in several structures, including external yolk syncytial layer; mesoderm; nervous system; neural tube; and optic cup. Orthologous to human ZNF503 (zinc finger protein 503).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55570 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Brown et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-znf503 | N/A | Brown et al., 2009 |
MO2-znf503 | N/A | Brown et al., 2009 |
MO3-znf503 | N/A | (4) |
MO4-znf503 | N/A | (4) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Elbow/Noc Zinc Finger | Transcriptional repressor NocA-like | Zinc finger C2H2-type |
---|---|---|---|---|---|
UniProtKB:Q6UFS5 | InterPro | 563 | |||
UniProtKB:B2GRW1 | InterPro | 563 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
znf503-201
(1)
|
Ensembl | 2,492 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-70E17 | ZFIN Curated Data | |
Encodes | EST | fc47h01 | ||
Encodes | EST | fi34f11 | ZFIN Curated Data | |
Encodes | cDNA | MGC:55570 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192368 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_198840 (1) | 2206 nt | ||
Genomic | GenBank:CT025897 (2) | 115873 nt | ||
Polypeptide | UniProtKB:B2GRW1 (1) | 563 aa |
- Silic, M.R., Black, M.M., Zhang, G. (2021) Phylogenetic and developmental analyses indicate complex functions of Calcium-Activated Potassium Channels in zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(10):1477-1493
- Covello, G., Rossello, F.J., Filosi, M., Gajardo, F., Duchemin, A.L., Tremonti, B.F., Eichenlaub, M., Polo, J.M., Powell, D., Ngai, J., Allende, M.L., Domenici, E., Ramialison, M., Poggi, L. (2020) Transcriptome analysis of the zebrafish atoh7-/- Mutant, lakritz, highlights Atoh7-dependent genetic networks with potential implications for human eye diseases. FASEB bioAdvances. 2:434-448
- Pereira Piedade, W., Veith, S., Famulski, J.K. (2019) Ubiquitin-mediated proteasome degradation regulates optic fissure fusion. Biology Open. 8(6):
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Labalette, C., Wassef, M.A., Desmarquet-Trin Dinh, C., Bouchoucha, Y.X., Le Men, J., Charnay, P., Gilardi-Hebenstreit, P. (2015) Molecular dissection of segment formation in the developing hindbrain. Development (Cambridge, England). 142:185-95
- Babcock, H.E., Dutta, S., Alur, R.P., Brocker, C., Vasiliou, V., Vitale, S., Abu-Asab, M., Brooks, B.P. (2014) aldh7a1 Regulates Eye and Limb Development in Zebrafish. PLoS One. 9:e101782
- Bouchoucha, Y.X., Reingruber, J., Labalette, C., Wassef, M.A., Thierion, E., Desmarquet-Trin Dinh, C., Holcman, D., Gilardi-Hebenstreit, P., and Charnay, P. (2013) Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning. Molecular Systems Biology. 9:690
- Lupo, G., Gestri, G., O'Brien, M., Denton, R.M., Chandraratna, R.A., Ley, S.V., Harris, W.A., and Wilson, S.W. (2011) Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Proceedings of the National Academy of Sciences of the United States of America. 108(21):8698-8703
- Feng, L., Hernandez, R.E., Waxman, J.S., Yelon, D., and Moens, C.B. (2010) Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Developmental Biology. 338(1):1-14
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