Gene
znf703
- ID
- ZDB-GENE-010717-1
- Name
- zinc finger protein 703
- Symbol
- znf703 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables histone deacetylase binding activity and identical protein binding activity. Acts upstream of or within several processes, including cilium assembly; embryonic camera-type eye morphogenesis; and negative regulation of DNA-templated transcription. Located in nucleus. Part of histone deacetylase complex. Is expressed in several structures, including anterior neural keel; mesoderm; nervous system; optic cup; and tail bud. Orthologous to human ZNF703 (zinc finger protein 703).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb514 (19 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-znf703 | Dutta et al., 2015 | |
| CRISPR2-znf703 | (2) | |
| CRISPR3-znf703 | (2) | |
| CRISPR4-znf703 | (2) | |
| CRISPR5-znf703 | (2) | |
| CRISPR6-znf703 | (2) | |
| CRISPR7-znf703 | (2) | |
| CRISPR8-znf703 | (2) | |
| CRISPR9-znf703 | (2) | |
| CRISPR10-znf703 | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Elbow/Noc Zinc Finger | Transcriptional repressor NocA-like | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:B2GT14 | InterPro | 589 | |||
| UniProtKB:Q90ZE2 | InterPro | 589 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
znf703-201
(1)
|
Ensembl | 2,948 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-158J20 | ZFIN Curated Data | |
| Encodes | EST | cb514 | Thisse et al., 2001 | |
| Encodes | EST | fc45d06 | ZFIN Curated Data | |
| Encodes | EST | fk28e09 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111927 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192810 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131822 (1) | 2978 nt | ||
| Genomic | GenBank:BX927172 (2) | 79111 nt | ||
| Polypeptide | UniProtKB:B2GT14 (1) | 589 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | ZNF703 | 8 | Amino acid sequence comparison (3) |
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- George, A., Lee, J., Liu, J., Kim, S., Brooks, B.P. (2022) Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(4):495-509
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Xu, J., Zhang, R., Zhang, T., Zhao, G., Huang, Y., Wang, H., Liu, J.X. (2017) Copper impairs zebrafish swimbladder development by down-regulating Wnt signaling. Aquatic toxicology (Amsterdam, Netherlands). 192:155-164
- Xu, S., Cao, S., Zou, B., Yue, Y., Gu, C., Chen, X., Wang, P., Dong, X., Xiang, Z., Li, K., Zhu, M., Zhao, Q., Zhou, G. (2016) An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease. Genome biology. 17:186
- Dutta, S., Sriskanda, S., Boobalan, E., Alur, R.P., Elkahloun, A., Brooks, B.P. (2015) nlz1 Is required for cilia formation in zebrafish embryogenesis. Developmental Biology. 406(2):203-11
- Labalette, C., Wassef, M.A., Desmarquet-Trin Dinh, C., Bouchoucha, Y.X., Le Men, J., Charnay, P., Gilardi-Hebenstreit, P. (2015) Molecular dissection of segment formation in the developing hindbrain. Development (Cambridge, England). 142:185-95
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Babcock, H.E., Dutta, S., Alur, R.P., Brocker, C., Vasiliou, V., Vitale, S., Abu-Asab, M., Brooks, B.P. (2014) aldh7a1 Regulates Eye and Limb Development in Zebrafish. PLoS One. 9:e101782
- Bouchoucha, Y.X., Reingruber, J., Labalette, C., Wassef, M.A., Thierion, E., Desmarquet-Trin Dinh, C., Holcman, D., Gilardi-Hebenstreit, P., and Charnay, P. (2013) Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning. Molecular Systems Biology. 9:690
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