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ZIRC
ZFIN ID: ZDB-GENE-990714-27
Gene Name: paired-like homeodomain 2
Gene Symbol: pitx2
Sequence Ontology ID : SO:0001217

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Previous Names: pitx2a, pitx2b, pitx2c, zpitx2c, zgc:110508

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have RNA polymerase II proximal promoter sequence-specific DNA binding activity and RNA polymerase II transcription factor binding activity. Involved in several processes, including  ...
GENE EXPRESSION
All Expression Data: 116 figures from 88 publications
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mw709 Small Deletion Unknown Premature Stop TALEN
sa250 Point Mutation Unknown Premature Stop ENU
sa22522 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sny3 Small Deletion Unknown Frameshift, Premature Stop TALEN
    sny6 Indel Unknown Frameshift, Premature Stop TALEN
    sny7 Small Deletion Unknown Frameshift, Premature Stop TALEN
    sny15 Indel Unknown Frameshift, Premature Stop TALEN
    ups6 Indel Unknown Frameshift TALEN
    Targeting reagents:
    PHENOTYPE
    Data: 29 figures from 7 publications
    Observed in:
    DISEASE ASSOCIATED WITH pitx2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Axenfeld-Rieger syndrome type 1 Axenfeld-Rieger syndrome, type 1 180500
    iridogoniodysgenesis syndrome Anterior segment dysgenesis 4 137600
    Ring dermoid of cornea 180550
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of digestive tract left/right asymmetry (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 29)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA pitx2-003 (1) 804
    pitx2-004 (1) 488
    mRNA pitx2-201 (1) 1947
    pitx2-203 (1) 1887
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM pitx2
    MARKER RELATIONSHIPS
    pitx2 Contained in: [BAC] DKEYP-96B6 (1)
    pitx2 Encodes: [cDNA] MGC:110508 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130975 (1) 1968 bp
    Genomic GenBank:BX511223 (1) 190254 bp
    Select Tool
    Polypeptide UniProtKB:Q9W5Z2 (1) 314 aa
    Sequence Clusters UniGene:81292 (1)
    Sequence Information (all 23)
    ORTHOLOGY for pitx2 ( Chr: 14 )
    CITATIONS (177)