FIGURE

Fig. 7

ID

ZDB-FIG-110622-125

Publication

Lupo et al., 2011 - Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme

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Fig. 7

Pax2 regulates some VR/OS genes in parallel to RAR signaling. (A and B) Lateral views of 25- to 26-hpf eyes. Approximately 15–20 control or mutant embryos for each probe were used for these analyses. (A) The noi embryos show down-regulation of net1a, cyb5a, and itgA5, but not vax1, in the VR/OS (arrowheads). Arrows point to itgA5 expression in extraocular tissue at the back of the eye. (B) Expression of dact1, nlz2, dhrs3a, and rdh10a in ventral eye cells is not affected in the noi mutants (arrowheads). Triangles point to nlz2 dorsal retinal expression. (C) Proposed model of the molecular mechanisms of RAR signaling in the developing zebrafish VR/OS (highlighted in gray). See text for details.

Expression Data

Genes:	cyb5a dact1 dhrs3a itga5 ntn1a rdh10a vax1 znf503
Fish:	WT pax2a^tu29a/tu29a
Anatomical Terms:	eye ventral region optic fissure optic stalk
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA