Gene

foxc1a

ID
ZDB-GENE-010302-1
Name
forkhead box C1a
Symbol
foxc1a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Exhibits chromatin binding activity. Involved in several processes, including animal organ development; regulation of signal transduction; and vasculature development. Predicted to localize to nucleus. Is expressed in several structures, including cardiovascular system; head; mesenchyme; mesoderm; and somite. Human ortholog(s) of this gene implicated in several diseases, including eye disease (multiple); lymphedema; lymphedema-distichiasis syndrome; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including FOXC1 (forkhead box C1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
40 figures from 25 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
29 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With foxc1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
anterior segment dysgenesis 3 Alliance Anterior segment dysgenesis 3, multiple subtypes 601631
Axenfeld-Rieger syndrome type 3 Alliance Axenfeld-Rieger syndrome, type 3 602482
iridogoniodysgenesis syndrome Alliance Anterior segment dysgenesis 3, multiple subtypes 601631
Associated With foxc1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018122 Fork head domain conserved site1
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Family IPR033067 Forkhead box protein C1
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Forkhead box protein C1 Fork head domain Fork head domain conserved site1 Fork head domain conserved site 2 Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q9DE25 476
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations