Gene
foxc1a
- ID
- ZDB-GENE-010302-1
- Name
- forkhead box C1a
- Symbol
- foxc1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Exhibits chromatin binding activity. Involved in several processes, including animal organ development; regulation of signal transduction; and vasculature development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including eye disease (multiple); lymphedema; lymphedema-distichiasis syndrome; obesity; and type 2 diabetes mellitus. Is expressed in several structures, including cardiovascular system; head; mesenchyme; mesoderm; and somite. Orthologous to several human genes including FOXC1 (forkhead box C1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 48 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63879 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 43 figures from 16 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anterior segment dysgenesis 3 | Alliance | Anterior segment dysgenesis 3, multiple subtypes | 601631 |
| Axenfeld-Rieger syndrome type 3 | Alliance | Axenfeld-Rieger syndrome, type 3 | 602482 |
| iridogoniodysgenesis syndrome | Alliance | Anterior segment dysgenesis 3, multiple subtypes | 601631 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Axenfeld-Rieger syndrome | foxc1anju18/nju18; f1Tg | standard conditions | Zhang et al., 2020 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR047391 | Forkhead box protein C1/C2-like, forkhead domain |
| Family | IPR050211 | Forkhead box domain-containing protein |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Forkhead box domain-containing protein | Forkhead box protein C1/C2-like, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9DE25
|
476 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxc1a-201
(1)
|
Ensembl | 2,175 nt |
Interactions and Pathways
No data available
Plasmids
No data available