Gene

foxc1a

ID
ZDB-GENE-010302-1
Name
forkhead box C1a
Symbol
foxc1a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Exhibits chromatin binding activity. Involved in several processes, including animal organ development; regulation of signal transduction; and vasculature development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including eye disease (multiple); lymphedema; lymphedema-distichiasis syndrome; obesity; and type 2 diabetes mellitus. Is expressed in several structures, including cardiovascular system; head; mesenchyme; mesoderm; and somite. Orthologous to several human genes including FOXC1 (forkhead box C1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
48 figures from 33 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
43 figures from 16 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
el542Allele with one deletionUnknownUnknownTALEN
el543Allele with one deletionUnknownUnknownTALEN
mw711Allele with one deletionUnknownUnknownCRISPR
mw717Allele with one deletionUnknownUnknownCRISPR
mw718Allele with one deletionUnknownUnknownCRISPR
mw719Allele with one deletionUnknownUnknownCRISPR
mw720Allele with one deletionUnknownUnknownCRISPR
mw721Allele with one deletionUnknownUnknownCRISPR
nju18Allele with one delinsUnknownUnknownTALEN
nju19Allele with one insertionUnknownUnknownTALEN
1 - 10 of 16
Show
Sequence Targeting Reagents
Human Disease
Associated With foxc1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
anterior segment dysgenesis 3 Alliance Anterior segment dysgenesis 3, multiple subtypes 601631
Axenfeld-Rieger syndrome type 3 Alliance Axenfeld-Rieger syndrome, type 3 602482
iridogoniodysgenesis syndrome Alliance Anterior segment dysgenesis 3, multiple subtypes 601631
1 - 3 of 3
Associated With foxc1a Via Experimental Models
1 - 1 of 1
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018122 Fork head domain conserved site1
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Domain IPR047391 Forkhead box protein C1/C2-like, forkhead domain
Family IPR050211 Forkhead box domain-containing protein
1 - 5 of 7 Show all
Domain Details Per Protein
Protein Length Forkhead box domain-containing protein Forkhead box protein C1/C2-like, forkhead domain Fork head domain Fork head domain conserved site1 Fork head domain conserved site 2 Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q9DE25 476
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 2
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA foxc1a-201 (1) Ensembl 2,175 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(UAS:foxc1a,cryaa:Cerulean)
  • Danio rerio
1Xu et al., 2018
1 - 1 of 1
Show
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-434G19ZFIN Curated Data
EncodescDNAMGC:63879
    ZFIN Curated Data
    1 - 2 of 2
    Show
    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanFOXC16
    Amino acid sequence comparison (1)
    MouseFoxc113
    Amino acid sequence comparison (1)
    Citations
    1 - 10 of 69
    Show