Gene
foxc1a
- ID
- ZDB-GENE-010302-1
- Name
- forkhead box C1a
- Symbol
- foxc1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Exhibits chromatin binding activity. Involved in several processes, including animal organ development; regulation of signal transduction; and vasculature development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including eye disease (multiple); lymphedema; lymphedema-distichiasis syndrome; obesity; and type 2 diabetes mellitus. Is expressed in several structures, including cardiovascular system; head; mesenchyme; mesoderm; and somite. Orthologous to several human genes including FOXC1 (forkhead box C1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 48 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63879 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 43 figures from 16 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
el542 | Allele with one deletion | Unknown | Unknown | TALEN | |
el543 | Allele with one deletion | Unknown | Unknown | TALEN | |
mw711 | Allele with one deletion | Unknown | Unknown | CRISPR | |
mw717 | Allele with one deletion | Unknown | Unknown | CRISPR | |
mw718 | Allele with one deletion | Unknown | Unknown | CRISPR | |
mw719 | Allele with one deletion | Unknown | Unknown | CRISPR | |
mw720 | Allele with one deletion | Unknown | Unknown | CRISPR | |
mw721 | Allele with one deletion | Unknown | Unknown | CRISPR | |
nju18 | Allele with one delins | Unknown | Unknown | TALEN | |
nju19 | Allele with one insertion | Unknown | Unknown | TALEN |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
anterior segment dysgenesis 3 | Alliance | Anterior segment dysgenesis 3, multiple subtypes | 601631 |
Axenfeld-Rieger syndrome type 3 | Alliance | Axenfeld-Rieger syndrome, type 3 | 602482 |
iridogoniodysgenesis syndrome | Alliance | Anterior segment dysgenesis 3, multiple subtypes | 601631 |
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Human Disease | Fish | Conditions | Citations |
---|---|---|---|
Axenfeld-Rieger syndrome | foxc1anju18/nju18; f1Tg | standard conditions | Zhang et al., 2020 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018122 | Fork head domain conserved site1 |
Conserved_site | IPR030456 | Fork head domain conserved site 2 |
Domain | IPR001766 | Fork head domain |
Domain | IPR047391 | Forkhead box protein C1/C2-like, forkhead domain |
Family | IPR050211 | Forkhead box domain-containing protein |
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Domain Details Per Protein
Protein | Length | Forkhead box domain-containing protein | Forkhead box protein C1/C2-like, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q9DE25
|
476 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
foxc1a-201
(1)
|
Ensembl | 2,175 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(UAS:foxc1a,cryaa:Cerulean) |
|
| 1 | Xu et al., 2018 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-434G19 | ZFIN Curated Data | |
Encodes | cDNA | MGC:63879 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131728 (1) | 2193 nt | ||
Genomic | GenBank:CU929125 (2) | 28376 nt | ||
Polypeptide | UniProtKB:Q9DE25 (1) | 476 aa |
- Shin, M., Yin, H.M., Shih, Y.H., Nozaki, T., Portman, D., Toles, B., Kolb, A., Luk, K., Isogai, S., Ishida, K., Hanasaka, T., Parsons, M.J., Wolfe, S.A., Burns, C.E., Burns, C.G., Lawson, N.D. (2023) Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish. Developmental Cell. 58(22):2614-2626.e7
- Chang, N.C., Rovira, Q., Wells, J.N., Feschotte, C., Vaquerizas, J.M. (2022) Zebrafish transposable elements show extensive diversification in age, genomic distribution, and developmental expression. Genome research. 32(7):1408-1423
- Duan, X., Shi, Y., Zhao, S., Yao, L., Sheng, J., Liu, D. (2022) Foxc1a regulates zebrafish vascular integrity and brain vascular development through targeting amotl2a and ctnnb1. Microvascular Research. 143:104400
- Ferre-Fernández, J.J., Muheisen, S., Thompson, S., Semina, E.V. (2022) CRISPR-Cas9-mediated functional dissection of the foxc1 genomic region in zebrafish identifies critical conserved cis-regulatory elements. Human genomics. 16:49
- Hawkey-Noble, A., Pater, J.A., Kollipara, R., Fitzgerald, M., Maekawa, A.S., Kovacs, C.S., Young, T.L., French, C.R. (2022) Mutation of foxl1 Results in Reduced Cartilage Markers in a Zebrafish Model of Otosclerosis. Genes. 13(7):
- Vöcking, O., Van Der Meulen, K., Patel, M.K., Famulski, J.K. (2022) Zebrafish anterior segment mesenchyme progenitors are defined by function of tfap2a but not sox10. Differentiation; research in biological diversity. 130:324232-42
- Watanabe, A., Muraki, K., Tamaoki, J., Kobayashi, M. (2022) Soy-Derived Equol Induces Antioxidant Activity in Zebrafish in an Nrf2-Independent Manner. International Journal of Molecular Sciences. 23(9)
- Brown, C., Mullins, L.J., Wesencraft, K., McConnell, G., Beltran, M., Henderson, N.C., Conway, B., Hoffmann, S., Rider, S., Mullins, J.J. (2021) scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 55:35-47
- Chrystal, P.W., French, C.R., Jean, F., Havrylov, S., van Baarle, S., Peturson, A.M., Xu, P., Crump, J.G., Pilgrim, D.B., Lehmann, O.J., Waskiewicz, A.J. (2021) The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning. Genes. 12(2):
- He, L., Zhang, Q., Jiang, D., Zhang, Y., Wei, Y., Yang, Y., Li, N., Wang, S., Yue, Y., Zhao, Q. (2021) Zebrafish foxc1a controls ventricular chamber maturation by directly regulating wwtr1 and nkx2.5 expression. Journal of genetics and genomics = Yi chuan xue bao. 49(6):559-568
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