Gene

itga5

ID

ZDB-GENE-031116-52

Name

integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

Symbol

itga5 Nomenclature History

Previous Names

bfe (1)
before eight (1)
sb:cb665
wu:fe02h07

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Exhibits fibronectin binding activity and protein heterodimerization activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; chordate embryonic development; and lens fiber cell morphogenesis. Predicted to localize to integrin complex. Is expressed in several structures, including cardiovascular system; ectoderm; head; mesoderm; and somite. Orthologous to human ITGA5 (integrin subunit alpha 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

23 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb665 (17 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 25 figures from 12 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With itga5 Human Ortholog

No data available

Associated With itga5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Domain	IPR013649	Integrin alpha, first immunoglubulin-like domain
Domain	IPR048285	Integrin alpha, second immunoglobulin-like domain
Domain	IPR048286	Integrin alpha, third immunoglobulin-like domain
Family	IPR000413	Integrin alpha chain
Homologous_superfamily	IPR028994	Integrin alpha, N-terminal
Homologous_superfamily	IPR032695	Integrin domain superfamily
Repeat	IPR013517	FG-GAP repeat
Repeat	IPR013519	Integrin alpha beta-propellor