Gene
dact1
- ID
- ZDB-GENE-040623-3
- Name
- dishevelled-binding antagonist of beta-catenin 1
- Symbol
- dact1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Acts upstream of or within Wnt signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including germ ring; immature eye; mesoderm; nervous system; and neural plate. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome. Orthologous to human DACT1 (dishevelled binding antagonist of beta catenin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu31 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Waxman et al., 2004
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-dact1 | N/A | Waxman et al., 2004 |
| MO2-dact1 | N/A | Waxman et al., 2004 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Townes-Brocks syndrome 2 | 617466 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR024843 | Dapper |
Domain Details Per Protein
| Protein | Additional Resources | Length | Dapper |
|---|---|---|---|
| UniProtKB:Q6QZN6 | InterPro | 821 | |
| UniProtKB:A0A8M1PR00 | InterPro | 821 |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-185A18 | ZFIN Curated Data | |
| Encodes | EST | eu31 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:152821 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193036 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214731 (1) | 3366 nt | ||
| Genomic | GenBank:CU179699 (1) | 147475 nt | ||
| Polypeptide | UniProtKB:A0A8M1PR00 (1) | 821 aa |
- Carroll, S.H., Schafer, S., Kawasaki, K., Tsimbal, C., Jule, A.M., Hallett, S.A., Li, E., Liao, E.C. (2024) Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis. eLIFE. 13:
- Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
- Zhou, S., Zhao, H., Thongda, W., Zhang, D., Su, B., Yu, D., Peatman, E., Li, C. (2016) Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Fish & shellfish immunology. 49:324-35
- Bouleau, A., Desvignes, T., Traverso, J.M., Nguyen, T., Chesnel, F., Fauvel, C., Bobe, J. (2014) Maternally-Inherited npm2 mRNA Is Crucial for Egg Developmental Competence in Zebrafish. Biology of reproduction. 91(2):43
- Mandal, A., Waxman, J. (2014) Retinoic acid negatively regulates dact3b expression in the hindbrain of zebrafish embryos. Gene expression patterns : GEP. 16(2):122-9
- Lee, M.T., Bonneau, A.R., Takacs, C.M., Bazzini, A.A., Divito, K.R., Fleming, E.S., and Giraldez, A.J. (2013) Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition. Nature. 503(7476):360-4
- Krol, A.J., Roellig, D., Dequéant, M.L., Tassy, O., Glynn, E., Hattem, G., Mushegian, A., Oates, A.C., and Pourquié, O. (2011) Evolutionary plasticity of segmentation clock networks. Development (Cambridge, England). 138(13):2783-2792
- Lupo, G., Gestri, G., O'Brien, M., Denton, R.M., Chandraratna, R.A., Ley, S.V., Harris, W.A., and Wilson, S.W. (2011) Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Proceedings of the National Academy of Sciences of the United States of America. 108(21):8698-8703
- Katoh, M., and Katoh, M. (2005) Identification and characterization of rat Dact1 and Dact2 genes in silico. International journal of molecular medicine. 15(6):1045-1049
- Waxman, J.S. (2005) Regulation of the early expression patterns of the zebrafish Dishevelled-interacting proteins Dapper1 and Dapper2. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(1):194-200
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