ZFIN ID: ZDB-LAB-980202-1581
Sinnhuber Aquatic Research Lab (SARL)
PI/Director: Tanguay, Robert L.
Contact Person: Tanguay, Robert L.
Email: Robert.Tanguay@oregonstate.edu
URL: http://ehsc.oregonstate.edu/SARL
Address: Environmental Health Sciences Center Oregon State University 68245 E. HWY 34 Corvallis OR 97331 USA
Country: United States
Phone: (541) 737-6514
Fax: (541) 737-6074
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LABNo data available


STATEMENT OF RESEARCH INTERESTS
The Sinnhuber Aquatic Research Laboratory (SARL) is a University core facility that supports aquatic research at Oregon State University (OSU). The SARL offers essential services including production of high quality zebrafish at multiple life stages, tank space, fish husbandry services, standard and custom diets, microinjections, and study design. The SARL supports research programs for OSU, and other national and international research groups. The SARL also provides specific pathogen free (Pseudoloma neurophilia) zebrafish to the research community.


LAB MEMBERS
Barton, Carrie Research Staff Gonnerman, Greg Research Staff Johnson, Eric Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Chlebowski, A.C., Garcia, G.R., La Du, J.K., Bisson, W.H., Truong, L., Massey Simonich, S.L., Tanguay, R.L. (2017) Mechanistic Investigations Into the Developmental Toxicity of Nitrated and Heterocyclic PAHs. Toxicological sciences : an official journal of the Society of Toxicology. 157:246-259
Garcia, G.R., Goodale, B.C., Wiley, M.W., La Du, J.K., Hendrix, D.A., Tanguay, R.L. (2017) In vivo characterization of an AHR-dependent long non-coding RNA required for proper Sox9b expression. Molecular pharmacology. 91(6):609-619
Beaver, L.M., Nkrumah-Elie, Y.M., Truong, L., Barton, C.L., Knecht, A.L., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model. The Journal of Nutritional Biochemistry. 43:78-87
Zhang, G., Truong, L., Tanguay, R.L., Reif, D.M. (2017) A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish. PLoS One. 12:e0169408
McDougall, M., Choi, J., Kim, H.K., Bobe, G., Stevens, J.F., Cadenas, E., Tanguay, R., Traber, M.G. (2017) Lethal Dysregulation of Energy Metabolism During Embryonic Vitamin E Deficiency. Free radical biology & medicine. 104:324-332
Zhang, G., Roell, K.R., Truong, L., Tanguay, R.L., Reif, D.M. (2016) A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicol. Appl. Pharmacol.. 314:109-117
Chen, J., Saili, K.S., Liu, Y., Li, L., Zhao, Y., Jia, Y., Bai, C., Tanguay, R.L., Dong, Q., Huang, C. (2016) Developmental bisphenol A exposure impairs sperm function and reproduction in zebrafish. Chemosphere. 169:262-270
Noyes, P.D., Garcia, G.R., Tanguay, R.L. (2016) ZEBRAFISH AS AN IN VIVO MODEL FOR SUSTAINABLE CHEMICAL DESIGN. Green chemistry : an international journal and green chemistry resource : GC. 18:6410-6430
Truong, L., Gonnerman, G., Simonich, M.T., Tanguay, R.L. (2016) Assessment of the developmental and neurotoxicity of the mosquito control larvicide, pyriproxyfen, using embryonic zebrafish. Environmental pollution (Barking, Essex : 1987). 218:1089-1093
Haggard, D.E., Noyes, P.D., Waters, K.M., Tanguay, R.L. (2016) Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish. Toxicol. Appl. Pharmacol.. 308:32-45
Bugel, S.M., Bonventre, J.A., Tanguay, R.L. (2016) Comparative developmental toxicity of flavonoids using an integrative zebrafish system. Toxicological sciences : an official journal of the Society of Toxicology. 154(1):55-68
Chen, J., Wang, X., Ge, X., Wang, D., Wang, T., Zhang, L., Tanguay, R.L., Simonich, M., Huang, C., Dong, Q. (2016) Chronic perfluorooctanesulphonic acid (PFOS) exposure produces estrogenic effects in zebrafish. Environmental pollution (Barking, Essex : 1987). 218:702-708
Truong, L., Simonich, M.T., Tanguay, R.L. (2016) Better, Faster, Cheaper: Getting the Most Out of High-Throughput Screening with Zebrafish. Methods in molecular biology (Clifton, N.J.). 1473:89-98
Truong, L., Bugel, S.M., Chlebowski, A., Usenko, C.Y., Simonich, M.T., Massey Simonich, S.L., Tanguay, R.L. (2016) Optimizing multi-dimensional high throughput screening using zebrafish. Reproductive toxicology (Elmsford, N.Y.). 65:139-147
Planchart, A., Mattingly, C.J., Allen, D., Ceger, P., Casey, W., Hinton, D., Kanungo, J., Kullman, S.W., Tal, T., Bondesson, M., Burgess, S.M., Sullivan, C., Kim, C., Behl, M., Padilla, S., Reif, D.M., Tanguay, R.L., Hamm, J. (2016) Advancing toxicology research using in vivo high throughput toxicology with small fish models. Altex. 33(4):435-452
Chen, J., Tanguay, R.L., Xiao, Y., Haggard, D.E., Ge, X., Jia, Y., Zheng, Y., Dong, Q., Huang, C., Lin, K. (2016) TBBPA exposure during a sensitive developmental window produces neurobehavioral changes in larval zebrafish. Environmental pollution (Barking, Essex : 1987). 216:53-63
Chen, J., Tanguay, R.L., Simonich, M., Nie, S., Zhao, Y., Li, L., Bai, C., Dong, Q., Huang, C., Lin, K. (2016) TBBPA chronic exposure produces sex-specific neurobehavioral and social interaction changes in adult zebrafish. Neurotoxicology and teratology. 56:9-15
Gaulke, C.A., Barton, C.L., Proffitt, S., Tanguay, R.L., Sharpton, T.J. (2016) Triclosan Exposure Is Associated with Rapid Restructuring of the Microbiome in Adult Zebrafish. PLoS One. 11:e0154632
Wehmas, L.C., Tanguay, R.L., Punnoose, A., Greenwood, J.A. (2016) Developing a Novel Embryo-Larval Zebrafish Xenograft Assay to Prioritize Human Glioblastoma Therapeutics. Zebrafish. 13(4):317-29
Chlebowski, A.C., Tanguay, R.L., Simonich, S.L. (2016) Quantitation and prediction of sorptive losses during toxicity testing of polycyclic aromatic hydrocarbon (PAH) and nitrated PAH (NPAH) using polystyrene 96-well plates. Neurotoxicology and teratology. 57:30-38
Zhang, G., Marvel, S., Truong, L., Tanguay, R.L., Reif, D.M. (2016) Aggregate Entropy Scoring for Quantifying Activity across Endpoints with Irregular Correlation Structure. Reproductive toxicology (Elmsford, N.Y.). 62:92-9
Olivares, C.I., Sierra-Alvarez, R., Abrell, L., Chorover, J., Simonich, M., Tanguay, R.L., Field, J.A. (2016) Zebrafish embryo toxicity of anaerobic biotransformation products from the insensitive munitions compound 2,4-dinitroanisole (DNAN). Environmental toxicology and chemistry. 35(11):2774-2781
Garcia, G.R., Noyes, P.D., Tanguay, R.L. (2016) Advancements in zebrafish applications for 21st century toxicology. Pharmacology & Therapeutics. 161:11-21
Barton, C.L., Johnson, E.W., Tanguay, R.L. (2016) Facility Design and Health Management Program at the Sinnhuber Aquatic Research Laboratory. Zebrafish. 13 Suppl 1:S39-43
Reed, R.B., Zaikova, T., Barber, A., Simonich, M., Lankone, R., Marco, M., Hristovski, K., Herckes, P., Passantino, L., Fairbrother, D.H., Tanguay, R., Ranville, J.F., Hutchison, J.E., Westerhoff, P.K. (2016) Potential Environmental Impacts and Antimicrobial Efficacy of Silver- and Nanosilver-Containing Textiles. Environ. Sci. Technol.. 50(7):4018-26
Bugel, S.M., Wehmas, L.C., La Du, J.K., Tanguay, R.L. (2016) Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicol. Appl. Pharmacol.. 296:31-41
Lemaire, B., Kubota, A., O'Meara, C.M., Lamb, D.C., Tanguay, R.L., Goldstone, J.V., Stegeman, J.J. (2016) Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicol. Appl. Pharmacol.. 296:73-84
Olivares, C.I., Field, J.A., Simonich, M., Tanguay, R.L., Sierra-Alvarez, R. (2016) Arsenic (III, V), indium (III), and gallium (III) toxicity to zebrafish embryos using a high-throughput multi-endpoint in vivo developmental and behavioral assay. Chemosphere. 148:361-368
McDougall, M.Q., Choi, J., Stevens, J.F., Truong, L., Tanguay, R.L., Traber, M.G. (2016) Lipidomics and H2(18)O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos. Redox Biology. 8:165-174
Chibwe, L., Geier, M.C., Nakamura, J., Tanguay, R.L., Aitken, M.D., Simonich, S.L. (2015) Aerobic Bioremediation of PAH Contaminated Soil Results in Increased Genotoxicity and Developmental Toxicity. Environ. Sci. Technol.. 49(23):13889-98
Goodale, B.C., La Du, J., Tilton, S.C., Sullivan, C.M., Bisson, W.H., Waters, K.M., Tanguay, R.L. (2015) Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs. Toxicological sciences : an official journal of the Society of Toxicology. 147(2):397-411
Reif, D.M., Truong, L., Mandrell, D., Marvel, S., Zhang, G., Tanguay, R.L. (2015) High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes. Archives of toxicology. 90(6):1459-70
Elie, M.R., Choi, J., Nkrumah-Elie, Y.M., Gonnerman, G.D., Stevens, J.F., Tanguay, R.L. (2015) Metabolomic analysis to define and compare the effects of PAHs and oxygenated PAHs in developing zebrafish. Environmental research. 140:502-510
Osborn, A.R., Almabruk, K.H., Holzwarth, G., Asamizu, S., LaDu, J., Kean, K.M., Karplus, P.A., Tanguay, R.L., Bakalinsky, A.T., Mahmud, T. (2015) De novo synthesis of a sunscreen compound in vertebrates. eLIFE. 4
Noyes, P.D., Haggard, D.E., Gonnerman, G.D., Tanguay, R.L. (2015) Advanced morphological-behavioral test platform reveals neurodevelopmental defects in embryonic zebrafish exposed to comprehensive suite of halogenated and organophosphate flame retardants. Toxicological sciences : an official journal of the Society of Toxicology. 145(1):177-95
Pan, L., Shah, A.N., Phelps, I.G., Doherty, D., Johnson, E.A., Moens, C.B. (2015) Rapid identification and recovery of ENU-induced mutations with next-generation sequencing and Paired-End Low-Error analysis. BMC Genomics. 16:83
Chatterjee, P., Padmanarayana, M., Abdullah, N., Holman, C.L., LaDu, J., Tanguay, R.L., Johnson, C.P. (2015) Otoferlin Deficiency In Zebrafish Results In Defects In Balance And Hearing: Rescue Of The Balance And Hearing Phenotype With Full-length And Truncated Forms Of Mouse Otoferlin. Molecular and cellular biology. 35(6):1043-54
Wehmas, L.C., Anders, C., Chess, J., Punnoose, A., Pereira, C.B., Greenwood, J.A., Tanguay, R.L. (2015) Comparative Metal Oxide Nanoparticle Toxicity Using Embryonic Zebrafish. Toxicology reports. 2:702-715
Bugel, S.M., Tanguay, R.L., Planchart, A. (2014) Zebrafish: A marvel of high-throughput biology for 21(st) century toxicology. Current environmental health reports. 1:341-352
Gerlach, C.V., Das, S.R., Volz, D.C., Bisson, W.H., Kolluri, S.K., Tanguay, R.L. (2014) Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 154C:71-79
Flentke, G.R., Klingler, R.H., Tanguay, R.L., Carvan, M.J., and Smith, S.M. (2014) An evolutionarily conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of fetal alcohol spectrum disorders. Alcoholism Clin. Exp. Res.. 38(5):1255-65
Truong, L., Mandrell, D., Mandrell, R., Simonich, M., Tanguay, R.L. (2014) A rapid throughput approach identifies cognitive deficits in adult zebrafish from developmental exposure to polybrominated flame retardants. Neurotoxicology. 43:134-42
Miller, G.W., Truong, L., Barton, C.L., Labut, E.M., Lebold, K.M., Traber, M.G., Tanguay, R.L. (2014) The influences of parental diet and vitamin E intake on the embryonic zebrafish transcriptome. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 10C:22-29
Motorykin, I., Traber, M.G., Tanguay, R.L., and Maier, C.S. (2014) Proteome-Driven Elucidation of Adaptive Responses to Combined Vitamin E and C Deficiency in Zebrafish. Journal of Proteome Research. 13(3):1647-56
Kent, M.L., Buchner, C., Barton, C., and Tanguay, R.L. (2014) Toxicity of chlorine to zebrafish embryos. Diseases of aquatic organisms. 107(3):235-240
Lebold, K.M., Kirkwood, J.S., Taylor, A.W., Choi, J., Barton, C.L., Miller, G.W., Du, J.L., Jump, D.B., Stevens, J.F., Tanguay, R.L., and Traber, M.G. (2013) Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. Redox Biology. 2:105-113
Levard, C., Hotze, E.M., Colman, B., Dale, A.L., Truong, L., Yang, X., Bone, A., Brown, G.E., Tanguay, R.L., Di Giulio, R.T., Bernhardt, E., Meyer, J., Wiesner, M.R., and Lowry, G.V. (2013) Sulfidation of Silver Nanoparticles: Natural antidote to their toxicity. Environ. Sci. Technol.. 47(23):13440-8
Truong, L., Reif, D., St Mary, L., Geier, M., Truong, H.D., and Tanguay, R.L. (2013) Multi-dimensional in vivo hazard assessment using zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 137(1):212-33
Franzosa, J.A., Bugel, S.M., Tal, T.L., La Du, J.K., Tilton, S.C., Waters, K.M., and Tanguay, R.L. (2013) Retinoic acid-dependent regulation of miR-19 expression elicits vertebrate axis defects. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(12):4866-76
Knecht, A.L., Goodale, B.C., Truong, L., Simonich, M.T., Swanson, A.J., Matzke, M.M., Anderson, K.A., Waters, K.M., and Tanguay, R.L. (2013) Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicol. Appl. Pharmacol.. 271(2):266-75
Goodale, B.C., Tilton, S.C., Corvi, M.M., Wilson, G.R., Janszen, D.B., Anderson, K.A., Waters, K.M., and Tanguay, R.L. (2013) Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish. Toxicol. Appl. Pharmacol.. 272(3):656-70
Lebold, K.M., Löhr, C.V., Barton, C.L., Miller, G.W., Labut, E.M., Tanguay, R.L., and Traber, M.G. (2013) Chronic vitamin E deficiency promotes vitamin C deficiency in zebrafish leading to degenerative myopathy and impaired swimming behavior. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 157(4):382-9
Kim, K.T., Zaikova, T., Hutchison, J.E., and Tanguay, R.L. (2013) Gold Nanoparticles Disrupt Zebrafish Eye Development and Pigmentation. Toxicological sciences : an official journal of the Society of Toxicology. 133(2):275-88
Kim, K.T., and Tanguay, R.L. (2013) Integrating zebrafish toxicology and nanoscience for safer product development. Green Chemistry. 15(4):872-880
Paquette, C.E., Kent, M.L., Buchner, C., Tanguay, R.L., Guillemin, K., Mason, T.J., and Peterson, T.S. (2013) A Retrospective Study of the Prevalence and Classification of Intestinal Neoplasia in Zebrafish (Danio rerio). Zebrafish. 10(2):228-36
Saili, K.S., Tilton, S.C., Waters, K.M., and Tanguay, R.L. (2013) Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17beta-estradiol in embryonic zebrafish. Reproductive toxicology (Elmsford, N.Y.). 38:89-101
Kim, K.T., Truong, L., Wehmas, L., and Tanguay, R.L. (2013) Silver nanoparticle toxicity in the embryonic zebrafish is governed by particle dispersion and ionic environment. Nanotechnology. 24(11):115101
Truong, L., Tilton, S.C., Zaikova, T., Richman, E., Waters, K.M., Hutchison, J.E., and Tanguay, R.L. (2013) Surface functionalities of gold nanoparticles impact embryonic gene expression responses. Nanotoxicology. 7:192-201
Chen, J., Das, S.R., La Du, J., Corvi, M.M., Bai, C., Chen, Y., Liu, X., Zhu, G., Tanguay, R.L., Dong, Q., and Huang, C. (2013) Chronic PFOS exposures induce life stage-specific behavioral deficits in adult zebrafish and produce malformation and behavioral deficits in F1 offspring. Environmental toxicology and chemistry. 32(1):201-206
Chen, J., Huang, C., Truong, L., La Du, J., Tilton, S.C., Waters, K.M., Lin, K., Tanguay, R.L., and Dong, Q. (2012) Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish. Toxicology. 302(2-3):129-139
Allan, S.E., Smith, B.W., Tanguay, R.L., and Anderson, K.A. (2012) Bridging environmental mixtures and toxic effects. Environmental toxicology and chemistry. 31(12):2877-2887
Truong, L., Zaikova, T., Richman, E.K., Hutchison, J.E., and Tanguay, R.L. (2012) Media ionic strength impacts embryonic responses to engineered nanoparticle exposure. Nanotoxicology. 6:691-699
Miller, G.W., Ulatowski, L., Labut, E.M., Lebold, K.M., Manor, D., Atkinson, J., Barton, C.L., Tanguay, R.L., and Traber, M.G. (2012) The alpha-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis. PLoS One. 7(10):e47402
Corvi, M.M., Stanley, K.A., Peterson, T.S., Kent, M.L., Feist, S.W., La Du, J.K., Volz, D.C., Hosmer, A.J., and Tanguay, R.L. (2012) Investigating the Impact of Chronic Atrazine Exposure on Sexual Development in Zebrafish. Birth defects research. Part B, Developmental and reproductive toxicology. 95(4):276-288
Sengupta, S., Bisson, W.H., Mathew, L.K., Kolluri, S.K., and Tanguay, R.L. (2012) Alternate glucocorticoid receptor ligand binding structures influence outcomes in an in vivo tissue regeneration model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 156(2):121-129
Mandrell, D., Truong, L., Jephson, C., Sarker, M.R., Moore, A., Lang, C., Simonich, M.T., and Tanguay, R.L. (2012) Automated zebrafish chorion removal and single embryo placement: optimizing throughput of zebrafish developmental toxicity screens. Journal of Laboratory Automation. 17(1):66-74
Tal, T.L., Franzosa, J.A., Tilton, S.C., Philbrick, K.A., Iwaniec, U.T., Turner, R.T., Waters, K.M., and Tanguay, R.L. (2012) MicroRNAs control neurobehavioral development and function in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(4):1452-1461
Goodale, B.C., La Du, J.K., Bisson, W.H., Janszen, D.B., Waters, K.M., and Tanguay, R.L. (2012) AHR2 Mutant Reveals Functional Diversity of Aryl Hydrocarbon Receptors in Zebrafish. PLoS One. 7(1):e29346
Lal, S., La Du, J., Tanguay, R.L., and Greenwood, J.A. (2011) Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment. Journal of neuroscience research. 90(4):769-781
Kirkwood, J.S., Lebold, K.M., Miranda, C.L., Wright, C.L., Miller, G.W., Tanguay, R.L., Barton, C.L., Traber, M.G., and Stevens, J.F. (2011) Vitamin C deficiency activates the purine nucleotide cycle in zebrafish. The Journal of biological chemistry. 287(6):3833-3841
Saili, K.S., Corvi, M.M., Weber, D.N., Patel, A.U., Das, S.R., Przybyla, J., Anderson, K.A., and Tanguay, R.L. (2011) Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish. Toxicology. 291(1-3):83-92
Lebold, K.M., Jump, D.B., Miller, G.W., Wright, C.L., Labut, E.M., Barton, C.L., Tanguay, R.L., and Traber, M.G. (2011) Vitamin E Deficiency Decreases Long-Chain Polyunsaturated Fatty Acid Status in Zebrafish (Danio rerio). The Journal of nutrition. 141(12):2113-8
Chen, J., Huang, C., Zheng, L., Simonich, M., Bai, C., Tanguay, R., and Dong, Q. (2011) Trimethyltin chloride (TMT) neurobehavioral toxicity in embryonic zebrafish. Neurotoxicol. Teratol.. 33(6):721-6
Miller, G.W., Labut, E.M., Lebold, K.M., Floeter, A., Tanguay, R.L., and Traber, M.G. (2011) Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality. The Journal of Nutritional Biochemistry. 23(5):478-486
Wang, M., Chen, J., Lin, K., Chen, Y., Hu, W., Tanguay, R.L., Huang, C., and Dong, Q. (2011) Chronic zebrafish PFOS exposure alters sex ratio and maternal related effects in F1 offspring. Environmental toxicology and chemistry. 30(9):2073-80
Kent, M.L., Buchner, C., Watral, V.G., Sanders, J.L., Ladu, J., Peterson, T.S., and Tanguay, R.L. (2011) Development and maintenance of a specific pathogen-free (SPF) zebrafish research facility for Pseudoloma neurophilia. Diseases of aquatic organisms. 95(1):73-79
Ho, E., Dukovcic, S., Hobson, B., Wong, C.P., Miller, G., Hardin, K., Traber, M.G., and Tanguay, R.L. (2011) Zinc transporter expression in zebrafish (Danio rerio) during development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 155(1):26-32
Yang, D., Lauridsen, H., Buels, K., Chi, L.H., La Du, J., Bruun, D., Olson, J.R., Tanguay, R.L., and Lein, P. (2011) Chlorpyrifos-Oxon Disrupts Zebrafish Axonal Growth and Motor Behavior. Toxicological sciences : an official journal of the Society of Toxicology. 121(1):146-59
Silbergeld, E.K., Contreras, E.Q., Hartung, T., Hirsch, C., Hogberg, H., Jachak, A.C., Jordan, W., Landsiedel, R., Morris, J., Patri, A., Pounds, J.G., de Vizcaya Ruiz, A., Shvedova, A., Tanguay, R., Tatarazako, N., van Vliet, E., Walker, N.J., Wiesner, M., Wilcox, N., and Zurlo, J. (2011) Nanotoxicology: "The end of the beginning" - Signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials. Altex. 28(3):236-241
Truong, L., Harper, S.L., and Tanguay, R.L. (2011) Evaluation of embryotoxicity using the zebrafish model. Meth. Mol. Biol.. 691:271-279
Truong, L., Moody, I.S., Stankus, D.P., Nason, J.A., Lonergan, M.C., and Tanguay, R.L. (2010) Differential stability of lead sulfide nanoparticles influences biological responses in embryonic zebrafish. Archives of toxicology. 85(7):787-98
O'Donnell, E.F., Saili, K.S., Koch, D.C., Kopparapu, P.R., Farrer, D., Bisson, W.H., Mathew, L.K., Sengupta, S., Kerkvliet, N.I., Tanguay, R.L., and Kolluri, S.K. (2010) The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One. 5(10):pii: e13128
Huang, H., Huang, C., Wang, L., Ye, X., Bai, C., Simonich, M.T., Tanguay, R.L., and Dong, Q. (2010) Toxicity, uptake kinetics and behavior assessment in zebrafish embryos following exposure to perfluorooctanesulphonicacid (PFOS). Aquatic toxicology (Amsterdam, Netherlands). 98(2):139-147
Hillwalker, W.E., Allan, S.E., Tanguay, R.L., and Anderson, K.A. (2010) Exploiting lipid-free tubing passive samplers and embryonic zebrafish to link site specific contaminant mixtures to biological responses. Chemosphere.. 79(1):1-7
Tal, T.L., Franzosa, J.A., and Tanguay, R.L. (2010) Molecular Signaling Networks That Choreograph Epimorphic Fin Regeneration in Zebrafish - A Mini-Review. Gerontology. 56(2):231-240
Stanley, K.A., Curtis, L.R., Massey Simonich, S.L., and Tanguay, R.L. (2009) Endosulfan I and endosulfan sulfate disrupts zebrafish embryonic development. Aquatic toxicology (Amsterdam, Netherlands). 95(4):355-361
Mathew, L.K., Sengupta, S., Franzosa, J., Perry, J., La Du, J., Andreasen, E.A., and Tanguay, R.L. (2009) Comparative expression profiling reveals an essential role for Raldh2 in epimorphic regeneration. The Journal of biological chemistry. 284(48):33642-33653
Welsh, L., Tanguay, R.L., and Svoboda, K.R. (2009) Uncoupling nicotine mediated motoneuron axonal pathfinding errors and muscle degeneration in zebrafish. Toxicol. Appl. Pharmacol.. 237(1):29-40
Mathew, L.K., Simonich, M.T., and Tanguay, R.L. (2009) AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration. Biochemical pharmacology. 77(4):498-507
Tilton, F., La Du, J.K., and Tanguay, R.L. (2008) Sulfhydryl systems are a critical factor in the zebrafish developmental toxicity of the dithiocarbamate sodium metam (NaM). Aquatic toxicology (Amsterdam, Netherlands). 90(2):121-127
Tilton, F., and Tanguay, R.L. (2008) Exposure to sodium metam during zebrafish somitogenesis results in early transcriptional indicators of the ensuing neuronal and muscular dysfunction. Toxicological sciences : an official journal of the Society of Toxicology. 106(1):103-112
Kent, M.L., Feist, S.W., Harper, C., Hoogstraten-Miller, S., Law, J.M., Sánchez-Morgado, J.M., Tanguay, R.L., Sanders, G.E., Spitsbergen, J.M., Whipps, C.M. (2008) Recommendations for control of pathogens and infectious diseases in fish research facilities. Comparative biochemistry and physiology. 149(2):240-248
Mathew, L.K., Sengupta, S.S., Ladu, J., Andreasen, E.A., and Tanguay, R.L. (2008) Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 22(8):3087-3096
Usenko, C.Y., Harper, S.L., and Tanguay, R.L. (2008) Fullerene C(60) exposure elicits an oxidative stress response in embryonic zebrafish. Toxicol. Appl. Pharmacol.. 229(1):44-55
Evans, B.R., Karchner, S.I., Allan, L.L., Pollenz, R.S., Tanguay, R.L., Jenny, M.J., Sherr, D.H., and Hahn, M.E. (2008) Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator. Molecular pharmacology. 73(2):387-398
Tanguay, R.L., and Reimers, M.J. (2008) Analysis of ethanol developmental toxicity in zebrafish. Meth. Mol. Biol.. 447:63-74
Isaacson, C.W., Usenko, C.Y., Tanguay, R.L., and Field, J.A. (2007) Quantification of Fullerenes by LC/ESI-MS and Its Application to in Vivo Toxicity Assays. Analytical chemistry. 79(23):9091-9097
Mathew, L.K., Sengupta, S., Kawakami, A., Andreasen, E.A., Löhr, C.V., Loynes, C.A., Renshaw, S.A., Peterson, R.T., and Tanguay, R.L. (2007) Unraveling tissue regeneration pathways using chemical genetics. The Journal of biological chemistry. 282(48):35202-35210
Usenko, C.Y., Harper, S.L., and Tanguay, R.L. (2007) In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish. Carbon. 45(9):1891-1898
Andreasen, E.A., Mathew, L.K., Lohr, C.V., Hasson, R., and Tanguay, R.L. (2007) Aryl Hydrocarbon Receptor Activation Impairs Extracellular Matrix Remodeling during Zebra Fish fin Regeneration. Toxicological sciences : an official journal of the Society of Toxicology. 95(1):215-226
Tilton, F., La Du, J.K., Vue, M., Alzarban, N., and Tanguay, R.L. (2006) Dithiocarbamates have a common toxic effect on zebrafish body axis formation. Toxicol. Appl. Pharmacol.. 216(1):55-68
Andreasen, E.A., Mathew, L.K., and Tanguay, R.L. (2006) Regenerative Growth is Impacted by TCDD: Gene Expression Analysis Reveals Extracellular Matrix Modulation. Toxicological sciences : an official journal of the Society of Toxicology. 92(1):254-269
Reimers, M.J., La Du, J.K., Periera, C.B., Giovanini, J., and Tanguay, R.L. (2006) Ethanol-dependent toxicity in zebrafish is partially attenuated by antioxidants. Neurotoxicol. Teratol.. 28(4):497-508
Teraoka, H., Urakawa, S., Nanba, S., Nagai, Y., Dong, W., Imagawa, T., Tanguay, R.L., Svoboda, K., Handley-Goldstone, H.M., Stegeman, J.J., and Hiraga, T. (2006) Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicol. Appl. Pharmacol.. 212(1):24-34
Prasch, A.L., Tanguay, R.L., Mehta, V., Heideman, W., and Peterson, R.E. (2006) Identification of Zebrafish ARNT1 Homologs: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Developing Zebrafish Requires ARNT1. Molecular pharmacology. 69(3):776-787
Mathew, L.K., Andreasen, E.A., and Tanguay, R.L. (2006) AHR Activation Inhibits Regenerative Growth. Molecular pharmacology. 69(1):257-265
Lassen, N., Estey, T., Tanguay, R., Pappa, A., Reimers, M., and Vasiliou, V. (2005) Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2. Drug metabolism and disposition: the biological fate of chemicals. 33(5):649-656
Reimers, M.J., Flockton, A.R., and Tanguay, R.L. (2004) Ethanol- and acetaldehyde-mediated developmental toxicity in zebrafish. Neurotoxicol. Teratol.. 26(6):769-781
Haendel, M.A., Tilton, F., Bailey, G.S., and Tanguay, R.L. (2004) Developmental Toxicity of the Dithiocarbamate Pesticide Sodium Metam in Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 81(2):390-400
Reimers, M.J., Hahn, M.E., and Tanguay, R.L. (2004) Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V ADH genes but have distinct functional characteristics. The Journal of biological chemistry. 279(37):38303-38312
Zodrow, J.M., Stegeman, J.J., and Tanguay, R.L. (2004) Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 66(1):25-38
Zodrow, J.M. and Tanguay, R.L. (2003) 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits zebrafish caudal fin regeneration. Toxicological sciences : an official journal of the Society of Toxicology. 76(1):151-161
Cao, Z., Tanguay, R.L., McKenzie, D., Peterson, R.E., and Aiken, J.M. (2003) Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout. Aquatic toxicology (Amsterdam, Netherlands). 63(3):271-282
Svoboda, K.R., Vijayaraghavan, S., and Tanguay, R.L. (2002) Nicotinic receptors mediate changes in spinal motoneuron development and axonal pathfinding in embryonic zebrafish exposed to nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(24):10731-10741
Andreasen, E.A., Spitsbergen, J.M., Tanguay, R.L., Stegeman, J.J., Heideman, W., and Peterson, R.E. (2002) Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure. Toxicological sciences : an official journal of the Society of Toxicology. 68(2):403-419
Andreasen, E.A., Hahn, M.E., Heideman, W., Peterson, R.E., and Tanguay, R.L. (2002) The zebrafish (Danio rerio) aryl hydrocarbon receptor type 1 (zfAHR1) is a novel vertebrate receptor. Molecular pharmacology. 62(2):234-249
Andreasen, E.A., Tanguay, R.L., Peterson, R.E., and Heideman, W. (2002) Identification of a critical amino acid in the Aryl hydrocarbon receptor. The Journal of biological chemistry. 277(15):13210-13218
Tanguay, R.L., Andreasen, E., Heideman, W., and Peterson, R.E. (2000) Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions. Biochim. Biophys. Acta Gene Struct. Exp.. 1494(1-2):117-128
Abnet, C.C., Tanguay, R.L., Heideman, W., and Peterson, R.E. (1999) Transactivation Activity of Human, Zebrafish, and Rainbow Trout Aryl Hydrocarbon Receptors Expressed in COS-7 Cells: Greater Insight into Species Differences in Toxic Potency of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners. Toxicol. Appl. Pharmacol.. 159(1):41-51
Tanguay, R.L., Abnet, C.C., Heideman, W., and Peterson, R.E. (1999) Cloning and characterization of the zebrafish (Danio rerio) aryl hydrocarbon receptor. Biochim. Biophys. Acta Gene Struct. Exp.. 1444:35-48