ZFIN ID: ZDB-LAB-980202-1581
Sinnhuber Aquatic Research Lab (SARL)
PI/Director: Tanguay, Robyn L.
Contact Person: Tanguay, Robyn L.
Email: Robert.Tanguay@oregonstate.edu
URL: http://ehsc.oregonstate.edu/SARL
Address: Environmental Health Sciences Center Oregon State University 68245 E. HWY 34 Corvallis OR 97331 USA
Country: United States
Phone: (541) 737-6514
Fax: (541) 737-6074
Line Designation: None assigned


The Sinnhuber Aquatic Research Laboratory (SARL) is a University core facility that supports aquatic research at Oregon State University (OSU). The SARL offers essential services including production of high quality zebrafish at multiple life stages, tank space, fish husbandry services, standard and custom diets, microinjections, and study design. The SARL supports research programs for OSU, and other national and international research groups. The SARL also provides specific pathogen free (Pseudoloma neurophilia) zebrafish to the research community.

Barton, Carrie Research Staff Gonnerman, Greg Research Staff Johnson, Eric Research Staff

Dasgupta, S., Dunham, C.L., Truong, L., Simonich, M.T., Sullivan, C.M., Tanguay, R.L. (2021) Phenotypically Anchored mRNA and miRNA Expression Profiling in Zebrafish Reveals Flame Retardant Chemical Toxicity Networks. Frontiers in cell and developmental biology. 9:663032
Chen, J., Li, J., Jiang, H., Yu, J., Wang, H., Wang, N., Chen, S., Mo, W., Wang, P., Tanguay, R.L., Dong, Q., Huang, C. (2021) Developmental co-exposure of TBBPA and titanium dioxide nanoparticle induced behavioral deficits in larval zebrafish. Ecotoxicology and environmental safety. 215:112176
Gamble, J.T., Elson, D.J., Greenwood, J.A., Tanguay, R.L., Kolluri, S.K. (2021) The Zebrafish Xenograft Models for Investigating Cancer and Cancer Therapeutics. Biology. 10(4):
Head, B., Ramsey, S.A., Kioussi, C., Tanguay, R.L., Traber, M.G. (2021) Vitamin E Deficiency Disrupts Gene Expression Networks during Zebrafish Development. Nutrients. 13(2):
To, K.T., St Mary, L., Wooley, A.H., Wilbanks, M.S., Bednar, A.J., Perkins, E.J., Truong, L., Tanguay, R.L., Garcia-Reyero, N. (2021) Morphological and Behavioral Effects in Zebrafish Embryos after Exposure to Smoke Dyes. Toxics. 9(1):
García-Jaramillo, M., Beaver, L.M., Truong, L., Axton, E.R., Keller, R.M., Prater, M.C., Magnusson, K.R., Tanguay, R.L., Stevens, J.F., Hord, N.G. (2020) Nitrate and nitrite exposure leads to mild anxiogenic-like behavior and alters brain metabolomic profile in zebrafish. PLoS One. 15:e0240070
Shankar, P., Dashner-Titus, E.J., Truong, L., Hayward, K., Hudson, L.G., Tanguay, R.L. (2020) Developmental toxicity in zebrafish (Danio rerio) exposed to uranium: A comparison with lead, cadmium, and iron. Environmental pollution (Barking, Essex : 1987). 269:116097
Zhang, J., Head, B., Leonard, S.W., Choi, J., Tanguay, R.L., Traber, M.G. (2020) Vitamin E deficiency dysregulates thiols, amino acids and related molecules during zebrafish embryogenesis. Redox Biology. 38:101784
Wilson, L.B., Truong, L., Simonich, M.T., Tanguay, R.L. (2020) Systematic Assessment of Exposure Variations on Observed Bioactivity in Zebrafish Chemical Screening. Toxics. 8(4):
Shankar, P., Dasgupta, S., Hahn, M.E., Tanguay, R.L. (2020) A Review of the Functional Roles of the Zebrafish Aryl Hydrocarbon Receptors. Toxicological sciences : an official journal of the Society of Toxicology. 178(2):215-238
Head, B., La Du, J., Tanguay, R.L., Kioussi, C., Traber, M.G. (2020) Vitamin E is necessary for zebrafish nervous system development. Scientific Reports. 10:15028
Dasgupta, S., Wang, G., Simonich, M.T., Zhang, T., Truong, L., Liu, H., Tanguay, R.L. (2020) Impacts of high dose 3.5 GHz cellphone radiofrequency on zebrafish embryonic development. PLoS One. 15:e0235869
Shelton, D.S., Shelton, S.G., Daniel, D.K., Raja, M., Bhat, A., Tanguay, R.L., Higgs, D.M., Martins, E.P. (2020) Collective Behavior in Wild Zebrafish. Zebrafish. 17(4):243-252
Shen, Q., Truong, L., Simonich, M.T., Huang, C., Tanguay, R.L., Dong, Q. (2020) Rapid well-plate assays for motor and social behaviors in larval zebrafish. Behavioural brain research. 391:112625
Garland, M.A., Geier, M.C., Bugel, S.M., Shankar, P., Dunham, C.L., Brown, J.M., Tilton, S.C., Tanguay, R.L. (2020) Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes. Toxicological sciences : an official journal of the Society of Toxicology. 176(1):46-64
Roper, C., Perez, A., Barrett, D., Hystad, P., Massey Simonich, S.L., Tanguay, R.L. (2020) Workflow for Comparison of Chemical and Biological Metrics of Filter Collected PM2.5. Atmospheric environment (Oxford, England : 1994). 226:
Li, C., Barton, C., Henke, K., Daane, J., Treaster, S., Caetano-Lopez, J., Tanguay, R.L., Harris, M. (2020) Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. eLIFE. 9:
McLaughlin, M.C., Blotevogel, J., Watson, R.A., Schell, B., Blewett, T.A., Folkerts, E.J., Goss, G.G., Truong, L., Tanguay, R.L., Argueso, J.L., Borch, T. (2020) Mutagenicity assessment downstream of oil and gas produced water discharges intended for agricultural beneficial reuse. The Science of the total environment. 715:136944
Roegner, A., Truong, L., Weirich, C., Pírez-Schirmer, M., Brena, B., Miller, T.R., Tanguay, R. (2019) Combined Danio rerio embryo morbidity, mortality and photomotor response assay: A tool for developmental risk assessment from chronic cyanoHAB exposure. The Science of the total environment. 697:134210
Falinski, M.M., Garland, M.A., Hashmi, S.M., Tanguay, R.L., Zimmerman, J.B. (2019) Establishing structure-property-hazard relationships for multi-walled carbon nanotubes: the role of aggregation, surface charge, and oxidative stress on embryonic zebrafish mortality. Carbon. 155:587-600
Holden, L.L., Truong, L., Simonich, M.T., Tanguay, R.L. (2019) Assessing the hazard of E-Cigarette flavor mixtures using zebrafish. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 136:110945
Rhyu, D., Lee, H., Tanguay, R.L., Kim, K.T. (2019) Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) disrupts zebrafish tail fin development. Ecotoxicology and environmental safety. 182:109449
Manchanda, A., Chatterjee, P., Bonventre, J.A., Haggard, D.E., Kindt, K.S., Tanguay, R.L., Johnson, C.P. (2019) Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish. Scientific Reports. 9:14273
Axton, E.R., Beaver, L.M., St Mary, L., Truong, L., Logan, C.R., Spagnoli, S., Prater, M.C., Keller, R.M., Garcia-Jaramillo, M., Ehrlicher, S.E., Stierwalt, H.D., Newsom, S.A., Robinson, M.M., Tanguay, R.L., Stevens, J.F., Hord, N.G. (2019) Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish. The Journal of nutrition. 149(12):2120-2132
Morgan, E., Gamble, J.T., Pearce, M.C., Elson, D.J., Tanguay, R.L., Kolluri, S.K., Reich, N.O. (2019) Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery. Apoptosis : an international journal on programmed cell death. 24:529-537
Chen, X., Chen, Y., Huang, C., Dong, Q., Roper, C., Tanguay, R.L., Zhu, Y., Zhang, Y. (2019) Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish. Ecotoxicology and environmental safety. 180:762-769
Garland, M.A., Sengupta, S., Mathew, L.K., Truong, L., de Jong, E., Piersma, A.H., La Du, J., Tanguay, R.L. (2019) Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration. Toxicology reports. 6:529-537
Shankar, P., Geier, M.C., Truong, L., McClure, R.S., Pande, P., Waters, K.M., Tanguay, R.L. (2019) Coupling Genome-wide Transcriptomics and Developmental Toxicity Profiles in Zebrafish to Characterize Polycyclic Aromatic Hydrocarbon (PAH) Hazard. International Journal of Molecular Sciences. 20(10):
Brown, J., Phillips, A.R., Lewis, D.A., Mans, M.A., Chang, Y., Tanguay, R.L., Peterson, E.S., Waters, K.M., Tilton, S.C. (2019) Bioinformatics Resource Manager: a systems biology web tool for microRNA and omics data integration. BMC Bioinformatics. 20:255
Broening, H.W., La Du, J., Carr, G.J., Nash, J.F., Truong, L., Tanguay, R.L. (2019) Determination of narcotic potency using a neurobehavioral assay with larval zebrafish. Neurotoxicology. 74:67-73
Truong, L., Zaikova, T., Baldock, B.L., Balik-Meisner, M., To, K., Reif, D.M., Kennedy, Z.C., Hutchison, J.E., Tanguay, R.L. (2019) Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish. Nanotoxicology. 13(7):879-893
Thomas, D.G., Shankaran, H., Truong, L., Tanguay, R.L., Waters, K.M. (2019) Time-dependent behavioral data from zebrafish reveals novel signatures of chemical toxicity using point of departure analysis. Computational toxicology (Amsterdam, Netherlands). 9:50-60
Bonventre, J.A., Holman, C., Manchanda, A., Codding, S.J., Chau, T., Huegel, J., Barton, C., Tanguay, R., Johnson, C.P. (2018) Fer1l6 Is Essential for the Development of Vertebrate Muscle Tissue in Zebrafish. Molecular biology of the cell. 30(3):293-301
Roper, C., Santiago Delgado, L., Barrett, D., Simonich, S.L.M., Tanguay, R.L. (2018) PM2.5 Filter Extraction Methods: Implications for Chemical and Toxicological Analyses. Environmental science & technology. 53(1):434-442
Hamm, J.T., Ceger, P., Allen, D., Stout, M., Maull, E.A., Baker, G., Zmarowski, A., Padilla, S., Perkins, E., Planchart, A., Stedman, D., Tal, T., Tanguay, R.L., Volz, D.C., Wilbanks, M.S., Walker, N.J. (2018) Characterizing sources of variability in zebrafish embryo screening protocols. Altex. 36(1):103-120
Garcia, G.R., Shankar, P., Dunham, C.L., Garcia, A., La Du, J.K., Truong, L., Tilton, S.C., Tanguay, R.L. (2018) Signaling Events Downstream of AHR Activation That Contribute to Toxic Responses: The Functional Role of an AHR-Dependent Long Noncoding RNA ( slincR) Using the Zebrafish Model. Environmental health perspectives. 126:117002
Hogan, D.E., Tian, F., Malm, S.W., Olivares, C., Palos Pacheco, R., Simonich, M.T., Hunjan, A.S., Tanguay, R.L., Klimecki, W.T., Polt, R., Pemberton, J.E., Curry, J.E., Maier, R.M. (2018) Biodegradability and toxicity of monorhamnolipid biosurfactant diastereomers. Journal of hazardous materials. 364:600-607
Gamble, J.T., Reed-Harris, Y., Barton, C.L., La Du, J., Tanguay, R., Greenwood, J.A. (2018) Quantification of glioblastoma progression in zebrafish xenografts: Adhesion to laminin alpha 5 promotes glioblastoma microtumor formation and inhibits cell invasion. Biochemical and Biophysical Research Communications. 506(4):833-839
Rizzo, M.J., Evans, J.P., Burt, M., Saunders, C.J., Johnson, E.C. (2018) Unexpected role of a conserved domain in the first extracellular loop in G protein-coupled receptor trafficking. Biochemical and Biophysical Research Communications. 503:1919-1926
Hagstrom, D., Truong, L., Zhang, S., Tanguay, R., Collins, E.S. (2018) Comparative analysis of zebrafish and planarian model systems for developmental neurotoxicity screens using an 87-compound library. Toxicological sciences : an official journal of the Society of Toxicology. 167(1):15-25
Kidd, J.M., Hanigan, D., Truong, L., Hristovski, K., Tanguay, R., Westerhoff, P. (2018) Developing and interpreting aqueous functional assays for comparative property-activity relationships of different nanoparticles. The Science of the total environment. 628-629:1609-1616
Balik-Meisner, M., Truong, L., Scholl, E.H., La Du, J.K., Tanguay, R.L., Reif, D.M. (2018) Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure. Environmental health perspectives. 126:067010
Pearce, M.C., Gamble, J.T., Kopparapu, P.R., O'Donnell, E.F., Mueller, M.J., Jang, H.S., Greenwood, J.A., Satterthwait, A.C., Tanguay, R.L., Zhang, X.K., Kolluri, S.K. (2018) Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells. Oncotarget. 9:26072-26085
Tanguay, R.L. (2018) The Rise of Zebrafish as a Model for Toxicology. Toxicological sciences : an official journal of the Society of Toxicology. 163:3-4
Ginzburg, A.L., Truong, L., Tanguay, R.L., Hutchison, J.E. (2018) Synergistic Toxicity Produced by Mixtures of Biocompatible Gold Nanoparticles and Widely Used Surfactants. ACS nano. 12(6):5312-5322
Geier, M.C., James Minick, D., Truong, L., Tilton, S., Pande, P., Anderson, K.A., Teeguardan, J., Tanguay, R.L. (2018) Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicology and applied pharmacology. 354:115-125
Roper, C., Simonich, S.L.M., Tanguay, R.L. (2018) Development of a high-throughput in vivo screening platform for particulate matter exposures. Environmental pollution (Barking, Essex : 1987). 235:993-1005
Hanigan, D., Truong, L., Schoepf, J., Nosaka, T., Mulchandani, A., Tanguay, R.L., Westerhoff, P. (2018) Trade-offs in ecosystem impacts from nanomaterial versus organic chemical ultraviolet filters in sunscreens. Water research. 139:281-290
Garcia, G.R., Bugel, S.M., Truong, L., Spagnoli, S., Tanguay, R.L. (2018) AHR2 required for normal behavioral responses and proper development of the skeletal and reproductive systems in zebrafish. PLoS One. 13:e0193484
Bugel, S.M., Tanguay, R.L. (2018) Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish. Toxicology and applied pharmacology. 344:23-34
Haggard, D.E., Noyes, P.D., Waters, K.M., Tanguay, R.L. (2018) Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists. Reproductive toxicology (Elmsford, N.Y.). 77:80-93
Madeira, C.L., Field, J.A., Simonich, M.T., Tanguay, R.L., Chorover, J., Sierra-Alvarez, R. (2018) Ecotoxicity of the insensitive munitions compound 3-nitro-1,2,4-triazol-5-one (NTO) and its reduced metabolite 3-amino-1,2,4-triazol-5-one (ATO). Journal of hazardous materials. 343:340-346
Balik-Meisner, M., Truong, L., Scholl, E.H., Tanguay, R.L., Reif, D.M. (2018) Population genetic diversity in zebrafish lines. Mammalian genome : official journal of the International Mammalian Genome Society. 29(1-2):90-100
Chen, J., Tian, L., Lei, L., Hou, F., Roper, C., Ge, X., Zhao, Y., Tanguay, R.L., Huang, C. (2018) Development and behavior alterations in zebrafish embryonically exposed to valproic acid (VPA): Animal model of autism. Neurotoxicology and teratology. 66:8-16
Oltová, J., Barton, C., Certal, A.C., Argenton, F., Varga, Z.M. (2018) 10th European Zebrafish Meeting 2017, Budapest: Husbandry Workshop Summary. Zebrafish.
Kim, J., Clark, K., Barton, C., Tanguay, R., Moulton, H. (2018) A Novel Zebrafish Model for Assessing In Vivo Delivery of Morpholino Oligomers. Methods in molecular biology (Clifton, N.J.). 1828:293-306
Jang, H.S., Pearce, M., O'Donnell, E.F., Nguyen, B.D., Truong, L., Mueller, M.J., Bisson, W.H., Kerkvliet, N.I., Tanguay, R.L., Kolluri, S.K. (2017) Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells. Biology. 6(4)
Geier, M.C., Chlebowski, A.C., Truong, L., Massey Simonich, S.L., Anderson, K.A., Tanguay, R.L. (2017) Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons. Archives of toxicology. 92(2):571-586
McDougall, M., Choi, J., Magnusson, K., Truong, L., Tanguay, R., Traber, M.G. (2017) Chronic vitamin E deficiency impairs cognitive function in adult zebrafish via dysregulation of brain lipids and energy metabolism. Free radical biology & medicine. 112:308-317
Bergmann, A.J., Tanguay, R.L., Anderson, K.A. (2017) Using passive sampling and zebrafish to identify developmental toxicants in complex mixtures. Environmental toxicology and chemistry. 36(9):2290-2298
McDougall, M., Choi, J., Truong, L., Tanguay, R., Traber, M.G. (2017) Vitamin E deficiency during embryogenesis in zebrafish causes lasting metabolic and cognitive impairments despite refeeding adequate diets. Free radical biology & medicine. 110:250-260
Beaver, L.M., Truong, L., Barton, C.L., Chase, T.T., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development. PLoS One. 12:e0183831
Knecht, A.L., Truong, L., Marvel, S.W., Reif, D.M., Garcia, A., Lu, C., Simonich, M.T., Teeguarden, J.G., Tanguay, R.L. (2017) Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish. Toxicology and applied pharmacology. 329:148-157
Hanigan, D., Truong, L., Simonich, M., Tanguay, R., Westerhoff, P. (2017) Zebrafish embryo toxicity of 15 chlorinated, brominated, and iodinated disinfection by-products. Journal of environmental sciences (China). 58:302-310
Schrlau, J.E., Kramer, A.L., Chlebowski, A., Truong, L., Tanguay, R.L., Simonich, S.L.M., Semprini, L. (2017) Formation of Developmentally Toxic Phenanthrene Metabolite Mixtures by Mycobacterium sp. ELW1. Environmental science & technology. 51(15):8569-8578
Singha, S., Shao, K., Yang, Y., Clemente-Casares, X., Solé, P., Clemente, A., Blanco, J., Dai, Q., Song, F., Liu, S.W., Yamanouchi, J., Umeshappa, C.S., Nanjundappa, R.H., Detampel, P., Amrein, M., Fandos, C., Tanguay, R., Newbigging, S., Serra, P., Khadra, A., Chan, W.C.W., Santamaria, P. (2017) Peptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices. Nature nanotechnology. 12(7):701-710
Garcia, G.R., Goodale, B.C., Wiley, M.W., La Du, J.K., Hendrix, D.A., Tanguay, R.L. (2017) In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression.. Molecular pharmacology. 91(6):609-619
Beaver, L.M., Nkrumah-Elie, Y.M., Truong, L., Barton, C.L., Knecht, A.L., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model. The Journal of Nutritional Biochemistry. 43:78-87
Chlebowski, A.C., Garcia, G.R., La Du, J.K., Bisson, W.H., Truong, L., Massey Simonich, S.L., Tanguay, R.L. (2017) Mechanistic Investigations Into the Developmental Toxicity of Nitrated and Heterocyclic PAHs. Toxicological sciences : an official journal of the Society of Toxicology. 157:246-259
McDougall, M., Choi, J., Kim, H.K., Bobe, G., Stevens, J.F., Cadenas, E., Tanguay, R., Traber, M.G. (2017) Lethal Dysregulation of Energy Metabolism During Embryonic Vitamin E Deficiency. Free radical biology & medicine. 104:324-332
McDougall, M., Choi, J., Kim, H.K., Bobe, G., Stevens, J.F., Cadenas, E., Tanguay, R., Traber, M.G. (2017) Lipid quantitation and metabolomics data from vitamin E-deficient and -sufficient zebrafish embryos from 0 to 120 hours-post-fertilization. Data in brief. 11:432-441
Haggard, D.E., Das, S.R., Tanguay, R.L. (2017) Comparative Toxicogenomic Responses to the Flame Retardant mITP in Developing Zebrafish. Chemical Research in Toxicology. 30(2):508-515
Chen, J., Saili, K.S., Liu, Y., Li, L., Zhao, Y., Jia, Y., Bai, C., Tanguay, R.L., Dong, Q., Huang, C. (2017) Developmental bisphenol A exposure impairs sperm function and reproduction in zebrafish. Chemosphere. 169:262-270
Zhang, G., Truong, L., Tanguay, R.L., Reif, D.M. (2017) A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish. PLoS One. 12:e0169408
Chlebowski, A.C., La Du, J.K., Truong, L., Massey Simonich, S.L., Tanguay, R.L. (2017) Investigating the application of a nitroreductase-expressing transgenic zebrafish line for high-throughput toxicity testing. Toxicology reports. 4:202-210
Truong, L., Tanguay, R.L. (2017) Evaluation of Embryotoxicity Using the Zebrafish Model. Methods in molecular biology (Clifton, N.J.). 1641:325-333
Zhang, G., Roell, K.R., Truong, L., Tanguay, R.L., Reif, D.M. (2017) A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicology and applied pharmacology. 314:109-117
Noyes, P.D., Garcia, G.R., Tanguay, R.L. (2016) ZEBRAFISH AS AN IN VIVO MODEL FOR SUSTAINABLE CHEMICAL DESIGN. Green chemistry : an international journal and green chemistry resource : GC. 18:6410-6430
Bugel, S.M., Bonventre, J.A., Tanguay, R.L. (2016) Comparative developmental toxicity of flavonoids using an integrative zebrafish system. Toxicological sciences : an official journal of the Society of Toxicology. 154(1):55-68
Chen, J., Wang, X., Ge, X., Wang, D., Wang, T., Zhang, L., Tanguay, R.L., Simonich, M., Huang, C., Dong, Q. (2016) Chronic perfluorooctanesulphonic acid (PFOS) exposure produces estrogenic effects in zebrafish. Environmental pollution (Barking, Essex : 1987). 218:702-708
Olivares, C.I., Sierra-Alvarez, R., Abrell, L., Chorover, J., Simonich, M., Tanguay, R.L., Field, J.A. (2016) Zebrafish embryo toxicity of anaerobic biotransformation products from the insensitive munitions compound 2,4-dinitroanisole (DNAN). Environmental toxicology and chemistry. 35(11):2774-2781
Truong, L., Gonnerman, G., Simonich, M.T., Tanguay, R.L. (2016) Assessment of the developmental and neurotoxicity of the mosquito control larvicide, pyriproxyfen, using embryonic zebrafish. Environmental pollution (Barking, Essex : 1987). 218:1089-1093
Haggard, D.E., Noyes, P.D., Waters, K.M., Tanguay, R.L. (2016) Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish. Toxicology and applied pharmacology. 308:32-45
Truong, L., Bugel, S.M., Chlebowski, A., Usenko, C.Y., Simonich, M.T., Massey Simonich, S.L., Tanguay, R.L. (2016) Optimizing multi-dimensional high throughput screening using zebrafish. Reproductive toxicology (Elmsford, N.Y.). 65:139-147
Chen, J., Tanguay, R.L., Xiao, Y., Haggard, D.E., Ge, X., Jia, Y., Zheng, Y., Dong, Q., Huang, C., Lin, K. (2016) TBBPA exposure during a sensitive developmental window produces neurobehavioral changes in larval zebrafish. Environmental pollution (Barking, Essex : 1987). 216:53-63
Chlebowski, A.C., Tanguay, R.L., Simonich, S.L. (2016) Quantitation and prediction of sorptive losses during toxicity testing of polycyclic aromatic hydrocarbon (PAH) and nitrated PAH (NPAH) using polystyrene 96-well plates. Neurotoxicology and teratology. 57:30-38
McDougall, M.Q., Choi, J., Stevens, J.F., Truong, L., Tanguay, R.L., Traber, M.G. (2016) Lipidomics and H2(18)O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos. Redox Biology. 8:165-174
Wehmas, L.C., Tanguay, R.L., Punnoose, A., Greenwood, J.A. (2016) Developing a Novel Embryo-Larval Zebrafish Xenograft Assay to Prioritize Human Glioblastoma Therapeutics. Zebrafish. 13(4):317-29
Barton, C.L., Johnson, E.W., Tanguay, R.L. (2016) Facility Design and Health Management Program at the Sinnhuber Aquatic Research Laboratory. Zebrafish. 13 Suppl 1:S39-43
Chen, J., Tanguay, R.L., Simonich, M., Nie, S., Zhao, Y., Li, L., Bai, C., Dong, Q., Huang, C., Lin, K. (2016) TBBPA chronic exposure produces sex-specific neurobehavioral and social interaction changes in adult zebrafish. Neurotoxicology and teratology. 56:9-15
Zhang, G., Marvel, S., Truong, L., Tanguay, R.L., Reif, D.M. (2016) Aggregate Entropy Scoring for Quantifying Activity across Endpoints with Irregular Correlation Structure. Reproductive toxicology (Elmsford, N.Y.). 62:92-9
Reif, D.M., Truong, L., Mandrell, D., Marvel, S., Zhang, G., Tanguay, R.L. (2016) High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes. Archives of toxicology. 90(6):1459-70
Gaulke, C.A., Barton, C.L., Proffitt, S., Tanguay, R.L., Sharpton, T.J. (2016) Triclosan Exposure Is Associated with Rapid Restructuring of the Microbiome in Adult Zebrafish. PLoS One. 11:e0154632
Garcia, G.R., Noyes, P.D., Tanguay, R.L. (2016) Advancements in zebrafish applications for 21st century toxicology. Pharmacology & Therapeutics. 161:11-21
Reed, R.B., Zaikova, T., Barber, A., Simonich, M., Lankone, R., Marco, M., Hristovski, K., Herckes, P., Passantino, L., Fairbrother, D.H., Tanguay, R., Ranville, J.F., Hutchison, J.E., Westerhoff, P.K. (2016) Potential Environmental Impacts and Antimicrobial Efficacy of Silver- and Nanosilver-Containing Textiles. Environmental science & technology. 50(7):4018-26
Bugel, S.M., Wehmas, L.C., La Du, J.K., Tanguay, R.L. (2016) Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicology and applied pharmacology. 296:31-41
Lemaire, B., Kubota, A., O'Meara, C.M., Lamb, D.C., Tanguay, R.L., Goldstone, J.V., Stegeman, J.J. (2016) Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicology and applied pharmacology. 296:73-84
Olivares, C.I., Field, J.A., Simonich, M., Tanguay, R.L., Sierra-Alvarez, R. (2016) Arsenic (III, V), indium (III), and gallium (III) toxicity to zebrafish embryos using a high-throughput multi-endpoint in vivo developmental and behavioral assay. Chemosphere. 148:361-368
Planchart, A., Mattingly, C.J., Allen, D., Ceger, P., Casey, W., Hinton, D., Kanungo, J., Kullman, S.W., Tal, T., Bondesson, M., Burgess, S.M., Sullivan, C., Kim, C., Behl, M., Padilla, S., Reif, D.M., Tanguay, R.L., Hamm, J. (2016) Advancing toxicology research using in vivo high throughput toxicology with small fish models. Altex. 33(4):435-452
Titaley, I., Chlebowski, A., Truong, L., Tanguay, R.L., Massey Simonicha, S.L. (2016) Identification and Toxicological Evaluation of Unsubstituted PAHs and Novel PAH Derivatives in Pavement Sealcoat Products. Environmental science & technology letters. 3:234-242
Truong, L., Simonich, M.T., Tanguay, R.L. (2016) Better, Faster, Cheaper: Getting the Most Out of High-Throughput Screening with Zebrafish. Methods in molecular biology (Clifton, N.J.). 1473:89-98
Chibwe, L., Geier, M.C., Nakamura, J., Tanguay, R.L., Aitken, M.D., Simonich, S.L. (2015) Aerobic Bioremediation of PAH Contaminated Soil Results in Increased Genotoxicity and Developmental Toxicity. Environmental science & technology. 49(23):13889-98
Goodale, B.C., La Du, J., Tilton, S.C., Sullivan, C.M., Bisson, W.H., Waters, K.M., Tanguay, R.L. (2015) Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs. Toxicological sciences : an official journal of the Society of Toxicology. 147(2):397-411
Elie, M.R., Choi, J., Nkrumah-Elie, Y.M., Gonnerman, G.D., Stevens, J.F., Tanguay, R.L. (2015) Metabolomic analysis to define and compare the effects of PAHs and oxygenated PAHs in developing zebrafish. Environmental research. 140:502-510
Osborn, A.R., Almabruk, K.H., Holzwarth, G., Asamizu, S., LaDu, J., Kean, K.M., Karplus, P.A., Tanguay, R.L., Bakalinsky, A.T., Mahmud, T. (2015) De novo synthesis of a sunscreen compound in vertebrates. eLIFE. 4
Noyes, P.D., Haggard, D.E., Gonnerman, G.D., Tanguay, R.L. (2015) Advanced morphological-behavioral test platform reveals neurodevelopmental defects in embryonic zebrafish exposed to comprehensive suite of halogenated and organophosphate flame retardants. Toxicological sciences : an official journal of the Society of Toxicology. 145(1):177-95
Chatterjee, P., Padmanarayana, M., Abdullah, N., Holman, C.L., LaDu, J., Tanguay, R.L., Johnson, C.P. (2015) Otoferlin Deficiency In Zebrafish Results In Defects In Balance And Hearing: Rescue Of The Balance And Hearing Phenotype With Full-length And Truncated Forms Of Mouse Otoferlin. Molecular and cellular biology. 35(6):1043-54
Pan, L., Shah, A.N., Phelps, I.G., Doherty, D., Johnson, E.A., Moens, C.B. (2015) Rapid identification and recovery of ENU-induced mutations with next-generation sequencing and Paired-End Low-Error analysis. BMC Genomics. 16:83
Wehmas, L.C., Anders, C., Chess, J., Punnoose, A., Pereira, C.B., Greenwood, J.A., Tanguay, R.L. (2015) Comparative Metal Oxide Nanoparticle Toxicity Using Embryonic Zebrafish. Toxicology reports. 2:702-715
Bugel, S.M., Tanguay, R.L., Planchart, A. (2014) Zebrafish: A marvel of high-throughput biology for 21st century toxicology.. Current environmental health reports. 1:341-352
Gerlach, C.V., Das, S.R., Volz, D.C., Bisson, W.H., Kolluri, S.K., Tanguay, R.L. (2014) Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 154C:71-79
Menelaou, E., Udvadia, A.J., Tanguay, R.L., Svoboda, K.R. (2014) Activation of α2A-containing nicotinic acetylcholine receptors mediates nicotine-induced motor output in embryonic zebrafish. The European journal of neuroscience. 40(1):2225-2240
Truong, L., Mandrell, D., Mandrell, R., Simonich, M., Tanguay, R.L. (2014) A rapid throughput approach identifies cognitive deficits in adult zebrafish from developmental exposure to polybrominated flame retardants. Neurotoxicology. 43:134-42
Miller, G.W., Truong, L., Barton, C.L., Labut, E.M., Lebold, K.M., Traber, M.G., Tanguay, R.L. (2014) The influences of parental diet and vitamin E intake on the embryonic zebrafish transcriptome. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 10C:22-29
Flentke, G.R., Klingler, R.H., Tanguay, R.L., Carvan, M.J., and Smith, S.M. (2014) An evolutionarily conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of fetal alcohol spectrum disorders. Alcoholism, clinical and experimental research. 38(5):1255-65
Motorykin, I., Traber, M.G., Tanguay, R.L., and Maier, C.S. (2014) Proteome-Driven Elucidation of Adaptive Responses to Combined Vitamin E and C Deficiency in Zebrafish. Journal of Proteome Research. 13(3):1647-56
Kent, M.L., Buchner, C., Barton, C., and Tanguay, R.L. (2014) Toxicity of chlorine to zebrafish embryos. Diseases of aquatic organisms. 107(3):235-240
Truong, L., Reif, D., St Mary, L., Geier, M., Truong, H.D., and Tanguay, R.L. (2014) Multi-dimensional in vivo hazard assessment using zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 137(1):212-33
Lebold, K.M., Kirkwood, J.S., Taylor, A.W., Choi, J., Barton, C.L., Miller, G.W., Du, J.L., Jump, D.B., Stevens, J.F., Tanguay, R.L., and Traber, M.G. (2013) Novel liquid chromatography-mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos. Redox Biology. 2:105-113
Franzosa, J.A., Bugel, S.M., Tal, T.L., La Du, J.K., Tilton, S.C., Waters, K.M., and Tanguay, R.L. (2013) Retinoic acid-dependent regulation of miR-19 expression elicits vertebrate axis defects. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(12):4866-76
Goodale, B.C., Tilton, S.C., Corvi, M.M., Wilson, G.R., Janszen, D.B., Anderson, K.A., Waters, K.M., and Tanguay, R.L. (2013) Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish. Toxicology and applied pharmacology. 272(3):656-70
Knecht, A.L., Goodale, B.C., Truong, L., Simonich, M.T., Swanson, A.J., Matzke, M.M., Anderson, K.A., Waters, K.M., and Tanguay, R.L. (2013) Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicology and applied pharmacology. 271(2):266-75
Saili, K.S., Tilton, S.C., Waters, K.M., and Tanguay, R.L. (2013) Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17beta-estradiol in embryonic zebrafish. Reproductive toxicology (Elmsford, N.Y.). 38:89-101
Kim, K.T., Zaikova, T., Hutchison, J.E., and Tanguay, R.L. (2013) Gold Nanoparticles Disrupt Zebrafish Eye Development and Pigmentation. Toxicological sciences : an official journal of the Society of Toxicology. 133(2):275-88
Paquette, C.E., Kent, M.L., Buchner, C., Tanguay, R.L., Guillemin, K., Mason, T.J., and Peterson, T.S. (2013) A Retrospective Study of the Prevalence and Classification of Intestinal Neoplasia in Zebrafish (Danio rerio). Zebrafish. 10(2):228-36
Lebold, K.M., Löhr, C.V., Barton, C.L., Miller, G.W., Labut, E.M., Tanguay, R.L., and Traber, M.G. (2013) Chronic vitamin E deficiency promotes vitamin C deficiency in zebrafish leading to degenerative myopathy and impaired swimming behavior. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 157(4):382-9
Kim, K.T., and Tanguay, R.L. (2013) Integrating zebrafish toxicology and nanoscience for safer product development. Green chemistry : an international journal and green chemistry resource : GC. 15(4):872-880
Kim, K.T., Truong, L., Wehmas, L., and Tanguay, R.L. (2013) Silver nanoparticle toxicity in the embryonic zebrafish is governed by particle dispersion and ionic environment. Nanotechnology. 24(11):115101
Truong, L., Tilton, S.C., Zaikova, T., Richman, E., Waters, K.M., Hutchison, J.E., and Tanguay, R.L. (2013) Surface functionalities of gold nanoparticles impact embryonic gene expression responses. Nanotoxicology. 7:192-201
Chen, J., Das, S.R., La Du, J., Corvi, M.M., Bai, C., Chen, Y., Liu, X., Zhu, G., Tanguay, R.L., Dong, Q., and Huang, C. (2013) Chronic PFOS exposures induce life stage-specific behavioral deficits in adult zebrafish and produce malformation and behavioral deficits in F1 offspring. Environmental toxicology and chemistry. 32(1):201-206
Levard, C., Hotze, E.M., Colman, B., Dale, A.L., Truong, L., Yang, X., Bone, A., Brown, G.E., Tanguay, R.L., Di Giulio, R.T., Bernhardt, E., Meyer, J., Wiesner, M.R., and Lowry, G.V. (2013) Sulfidation of Silver Nanoparticles: Natural antidote to their toxicity. Environmental science & technology. 47(23):13440-8
Chen, J., Huang, C., Truong, L., La Du, J., Tilton, S.C., Waters, K.M., Lin, K., Tanguay, R.L., and Dong, Q. (2012) Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish. Toxicology. 302(2-3):129-139
Allan, S.E., Smith, B.W., Tanguay, R.L., and Anderson, K.A. (2012) Bridging environmental mixtures and toxic effects. Environmental toxicology and chemistry. 31(12):2877-2887
Truong, L., Zaikova, T., Richman, E.K., Hutchison, J.E., and Tanguay, R.L. (2012) Media ionic strength impacts embryonic responses to engineered nanoparticle exposure. Nanotoxicology. 6:691-699
Corvi, M.M., Stanley, K.A., Peterson, T.S., Kent, M.L., Feist, S.W., La Du, J.K., Volz, D.C., Hosmer, A.J., and Tanguay, R.L. (2012) Investigating the Impact of Chronic Atrazine Exposure on Sexual Development in Zebrafish. Birth defects research. Part B, Developmental and reproductive toxicology. 95(4):276-288
Sengupta, S., Bisson, W.H., Mathew, L.K., Kolluri, S.K., and Tanguay, R.L. (2012) Alternate glucocorticoid receptor ligand binding structures influence outcomes in an in vivo tissue regeneration model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 156(2):121-129
Miller, G.W., Labut, E.M., Lebold, K.M., Floeter, A., Tanguay, R.L., and Traber, M.G. (2012) Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality. The Journal of Nutritional Biochemistry. 23(5):478-486
Lal, S., La Du, J., Tanguay, R.L., and Greenwood, J.A. (2012) Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment. Journal of neuroscience research. 90(4):769-781
Tal, T.L., Franzosa, J.A., Tilton, S.C., Philbrick, K.A., Iwaniec, U.T., Turner, R.T., Waters, K.M., and Tanguay, R.L. (2012) MicroRNAs control neurobehavioral development and function in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(4):1452-1461
Kirkwood, J.S., Lebold, K.M., Miranda, C.L., Wright, C.L., Miller, G.W., Tanguay, R.L., Barton, C.L., Traber, M.G., and Stevens, J.F. (2012) Vitamin C deficiency activates the purine nucleotide cycle in zebrafish. The Journal of biological chemistry. 287(6):3833-3841
Mandrell, D., Truong, L., Jephson, C., Sarker, M.R., Moore, A., Lang, C., Simonich, M.T., and Tanguay, R.L. (2012) Automated zebrafish chorion removal and single embryo placement: optimizing throughput of zebrafish developmental toxicity screens. Journal of Laboratory Automation. 17(1):66-74
Saili, K.S., Corvi, M.M., Weber, D.N., Patel, A.U., Das, S.R., Przybyla, J., Anderson, K.A., and Tanguay, R.L. (2012) Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish. Toxicology. 291(1-3):83-92
Goodale, B.C., La Du, J.K., Bisson, W.H., Janszen, D.B., Waters, K.M., and Tanguay, R.L. (2012) AHR2 Mutant Reveals Functional Diversity of Aryl Hydrocarbon Receptors in Zebrafish. PLoS One. 7(1):e29346
Ho, E., Dukovcic, S., Hobson, B., Wong, C.P., Miller, G., Hardin, K., Traber, M.G., and Tanguay, R.L. (2012) Zinc transporter expression in zebrafish (Danio rerio) during development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 155(1):26-32
Miller, G.W., Ulatowski, L., Labut, E.M., Lebold, K.M., Manor, D., Atkinson, J., Barton, C.L., Tanguay, R.L., and Traber, M.G. (2012) The alpha-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis. PLoS One. 7(10):e47402
Lebold, K.M., Jump, D.B., Miller, G.W., Wright, C.L., Labut, E.M., Barton, C.L., Tanguay, R.L., and Traber, M.G. (2011) Vitamin E Deficiency Decreases Long-Chain PUFA in Zebrafish (Danio rerio). The Journal of nutrition. 141(12):2113-8
Chen, J., Huang, C., Zheng, L., Simonich, M., Bai, C., Tanguay, R., and Dong, Q. (2011) Trimethyltin chloride (TMT) neurobehavioral toxicity in embryonic zebrafish. Neurotoxicology and teratology. 33(6):721-6
Wang, M., Chen, J., Lin, K., Chen, Y., Hu, W., Tanguay, R.L., Huang, C., and Dong, Q. (2011) Chronic zebrafish PFOS exposure alters sex ratio and maternal related effects in F1 offspring. Environmental toxicology and chemistry. 30(9):2073-80
Truong, L., Moody, I.S., Stankus, D.P., Nason, J.A., Lonergan, M.C., and Tanguay, R.L. (2011) Differential stability of lead sulfide nanoparticles influences biological responses in embryonic zebrafish. Archives of toxicology. 85(7):787-98
Kent, M.L., Buchner, C., Watral, V.G., Sanders, J.L., Ladu, J., Peterson, T.S., and Tanguay, R.L. (2011) Development and maintenance of a specific pathogen-free (SPF) zebrafish research facility for Pseudoloma neurophilia. Diseases of aquatic organisms. 95(1):73-79
Yang, D., Lauridsen, H., Buels, K., Chi, L.H., La Du, J., Bruun, D., Olson, J.R., Tanguay, R.L., and Lein, P. (2011) Chlorpyrifos-Oxon Disrupts Zebrafish Axonal Growth and Motor Behavior. Toxicological sciences : an official journal of the Society of Toxicology. 121(1):146-59
Silbergeld, E.K., Contreras, E.Q., Hartung, T., Hirsch, C., Hogberg, H., Jachak, A.C., Jordan, W., Landsiedel, R., Morris, J., Patri, A., Pounds, J.G., de Vizcaya Ruiz, A., Shvedova, A., Tanguay, R., Tatarazako, N., van Vliet, E., Walker, N.J., Wiesner, M., Wilcox, N., and Zurlo, J. (2011) Nanotoxicology: "The end of the beginning" - Signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials. Altex. 28(3):236-241
Truong, L., Harper, S.L., and Tanguay, R.L. (2011) Evaluation of embryotoxicity using the zebrafish model. Methods in molecular biology (Clifton, N.J.). 691:271-279
O'Donnell, E.F., Saili, K.S., Koch, D.C., Kopparapu, P.R., Farrer, D., Bisson, W.H., Mathew, L.K., Sengupta, S., Kerkvliet, N.I., Tanguay, R.L., and Kolluri, S.K. (2010) The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One. 5(10):pii: e13128
Huang, H., Huang, C., Wang, L., Ye, X., Bai, C., Simonich, M.T., Tanguay, R.L., and Dong, Q. (2010) Toxicity, uptake kinetics and behavior assessment in zebrafish embryos following exposure to perfluorooctanesulphonicacid (PFOS). Aquatic toxicology (Amsterdam, Netherlands). 98(2):139-147
Hillwalker, W.E., Allan, S.E., Tanguay, R.L., and Anderson, K.A. (2010) Exploiting lipid-free tubing passive samplers and embryonic zebrafish to link site specific contaminant mixtures to biological responses. Chemosphere. 79(1):1-7
Tal, T.L., Franzosa, J.A., and Tanguay, R.L. (2010) Molecular Signaling Networks That Choreograph Epimorphic Fin Regeneration in Zebrafish - A Mini-Review. Gerontology. 56(2):231-240
Stanley, K.A., Curtis, L.R., Massey Simonich, S.L., and Tanguay, R.L. (2009) Endosulfan I and endosulfan sulfate disrupts zebrafish embryonic development. Aquatic toxicology (Amsterdam, Netherlands). 95(4):355-361
Mathew, L.K., Sengupta, S., Franzosa, J., Perry, J., La Du, J., Andreasen, E.A., and Tanguay, R.L. (2009) Comparative expression profiling reveals an essential role for Raldh2 in epimorphic regeneration. The Journal of biological chemistry. 284(48):33642-33653
Welsh, L., Tanguay, R.L., and Svoboda, K.R. (2009) Uncoupling nicotine mediated motoneuron axonal pathfinding errors and muscle degeneration in zebrafish. Toxicology and applied pharmacology. 237(1):29-40
Kent, M.L., Feist, S.W., Harper, C., Hoogstraten-Miller, S., Law, J.M., Sánchez-Morgado, J.M., Tanguay, R.L., Sanders, G.E., Spitsbergen, J.M., Whipps, C.M. (2009) Recommendations for control of pathogens and infectious diseases in fish research facilities. Comparative biochemistry and physiology. 149(2):240-248
Mathew, L.K., Simonich, M.T., and Tanguay, R.L. (2009) AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration. Biochemical pharmacology. 77(4):498-507
Tilton, F., La Du, J.K., and Tanguay, R.L. (2008) Sulfhydryl systems are a critical factor in the zebrafish developmental toxicity of the dithiocarbamate sodium metam (NaM). Aquatic toxicology (Amsterdam, Netherlands). 90(2):121-127
Tilton, F., and Tanguay, R.L. (2008) Exposure to sodium metam during zebrafish somitogenesis results in early transcriptional indicators of the ensuing neuronal and muscular dysfunction. Toxicological sciences : an official journal of the Society of Toxicology. 106(1):103-112
Mathew, L.K., Sengupta, S.S., Ladu, J., Andreasen, E.A., and Tanguay, R.L. (2008) Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 22(8):3087-3096
Usenko, C.Y., Harper, S.L., and Tanguay, R.L. (2008) Fullerene C(60) exposure elicits an oxidative stress response in embryonic zebrafish. Toxicology and applied pharmacology. 229(1):44-55
Evans, B.R., Karchner, S.I., Allan, L.L., Pollenz, R.S., Tanguay, R.L., Jenny, M.J., Sherr, D.H., and Hahn, M.E. (2008) Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator. Molecular pharmacology. 73(2):387-398
Tanguay, R.L., and Reimers, M.J. (2008) Analysis of ethanol developmental toxicity in zebrafish. Methods in molecular biology (Clifton, N.J.). 447:63-74
Isaacson, C.W., Usenko, C.Y., Tanguay, R.L., and Field, J.A. (2007) Quantification of Fullerenes by LC/ESI-MS and Its Application to in Vivo Toxicity Assays. Analytical chemistry. 79(23):9091-9097
Mathew, L.K., Sengupta, S., Kawakami, A., Andreasen, E.A., Löhr, C.V., Loynes, C.A., Renshaw, S.A., Peterson, R.T., and Tanguay, R.L. (2007) Unraveling tissue regeneration pathways using chemical genetics. The Journal of biological chemistry. 282(48):35202-35210
Usenko, C.Y., Harper, S.L., and Tanguay, R.L. (2007) In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish. Carbon. 45(9):1891-1898
Andreasen, E.A., Mathew, L.K., Lohr, C.V., Hasson, R., and Tanguay, R.L. (2007) Aryl Hydrocarbon Receptor Activation Impairs Extracellular Matrix Remodeling during Zebra Fish fin Regeneration. Toxicological sciences : an official journal of the Society of Toxicology. 95(1):215-226
Tilton, F., La Du, J.K., Vue, M., Alzarban, N., and Tanguay, R.L. (2006) Dithiocarbamates have a common toxic effect on zebrafish body axis formation. Toxicology and applied pharmacology. 216(1):55-68
Andreasen, E.A., Mathew, L.K., and Tanguay, R.L. (2006) Regenerative Growth is Impacted by TCDD: Gene Expression Analysis Reveals Extracellular Matrix Modulation. Toxicological sciences : an official journal of the Society of Toxicology. 92(1):254-269
Reimers, M.J., La Du, J.K., Periera, C.B., Giovanini, J., and Tanguay, R.L. (2006) Ethanol-dependent toxicity in zebrafish is partially attenuated by antioxidants. Neurotoxicology and teratology. 28(4):497-508
Teraoka, H., Urakawa, S., Nanba, S., Nagai, Y., Dong, W., Imagawa, T., Tanguay, R.L., Svoboda, K., Handley-Goldstone, H.M., Stegeman, J.J., and Hiraga, T. (2006) Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicology and applied pharmacology. 212(1):24-34
Prasch, A.L., Tanguay, R.L., Mehta, V., Heideman, W., and Peterson, R.E. (2006) Identification of Zebrafish ARNT1 Homologs: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Developing Zebrafish Requires ARNT1. Molecular pharmacology. 69(3):776-787
Mathew, L.K., Andreasen, E.A., and Tanguay, R.L. (2006) AHR Activation Inhibits Regenerative Growth. Molecular pharmacology. 69(1):257-265
Lassen, N., Estey, T., Tanguay, R., Pappa, A., Reimers, M., and Vasiliou, V. (2005) Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2. Drug metabolism and disposition: the biological fate of chemicals. 33(5):649-656
Reimers, M.J., Flockton, A.R., and Tanguay, R.L. (2004) Ethanol- and acetaldehyde-mediated developmental toxicity in zebrafish. Neurotoxicology and teratology. 26(6):769-781
Haendel, M.A., Tilton, F., Bailey, G.S., and Tanguay, R.L. (2004) Developmental Toxicity of the Dithiocarbamate Pesticide Sodium Metam in Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 81(2):390-400
Reimers, M.J., Hahn, M.E., and Tanguay, R.L. (2004) Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V ADH genes but have distinct functional characteristics. The Journal of biological chemistry. 279(37):38303-38312
Zodrow, J.M., Stegeman, J.J., and Tanguay, R.L. (2004) Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 66(1):25-38
Zodrow, J.M. and Tanguay, R.L. (2003) 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits zebrafish caudal fin regeneration. Toxicological sciences : an official journal of the Society of Toxicology. 76(1):151-161
Cao, Z., Tanguay, R.L., McKenzie, D., Peterson, R.E., and Aiken, J.M. (2003) Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout. Aquatic toxicology (Amsterdam, Netherlands). 63(3):271-282
Svoboda, K.R., Vijayaraghavan, S., and Tanguay, R.L. (2002) Nicotinic receptors mediate changes in spinal motoneuron development and axonal pathfinding in embryonic zebrafish exposed to nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(24):10731-10741
Andreasen, E.A., Hahn, M.E., Heideman, W., Peterson, R.E., and Tanguay, R.L. (2002) The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor. Molecular pharmacology. 62(2):234-249
Andreasen, E.A., Spitsbergen, J.M., Tanguay, R.L., Stegeman, J.J., Heideman, W., and Peterson, R.E. (2002) Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure. Toxicological sciences : an official journal of the Society of Toxicology. 68(2):403-419
Andreasen, E.A., Tanguay, R.L., Peterson, R.E., and Heideman, W. (2002) Identification of a critical amino acid in the Aryl hydrocarbon receptor. The Journal of biological chemistry. 277(15):13210-13218
Tanguay, R.L., Andreasen, E., Heideman, W., and Peterson, R.E. (2000) Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions. Biochim. Biophys. Acta Gene Struct. Exp.. 1494(1-2):117-128
Abnet, C.C., Tanguay, R.L., Heideman, W., and Peterson, R.E. (1999) Transactivation Activity of Human, Zebrafish, and Rainbow Trout Aryl Hydrocarbon Receptors Expressed in COS-7 Cells: Greater Insight into Species Differences in Toxic Potency of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners. Toxicology and applied pharmacology. 159(1):41-51
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