PUBLICATION
Nanotoxicology: "The end of the beginning" - Signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials
- Authors
- Silbergeld, E.K., Contreras, E.Q., Hartung, T., Hirsch, C., Hogberg, H., Jachak, A.C., Jordan, W., Landsiedel, R., Morris, J., Patri, A., Pounds, J.G., de Vizcaya Ruiz, A., Shvedova, A., Tanguay, R., Tatarazako, N., van Vliet, E., Walker, N.J., Wiesner, M., Wilcox, N., and Zurlo, J.
- ID
- ZDB-PUB-111027-4
- Date
- 2011
- Source
- Altex 28(3): 236-241 (Other)
- Registered Authors
- Silbergeld, Ellen K., Tanguay, Robyn L.
- Keywords
- none
- MeSH Terms
-
- Animal Testing Alternatives/methods
- Animals
- Caenorhabditis elegans
- Investigational New Drug Application
- Models, Biological
- Nanostructures/chemistry*
- Nanostructures/toxicity*
- Pharmaceutical Preparations/chemistry
- Toxicity Tests/methods*
- United States
- United States Food and Drug Administration
- Zebrafish
- PubMed
- 21993959 Full text @ Altex
Citation
Silbergeld, E.K., Contreras, E.Q., Hartung, T., Hirsch, C., Hogberg, H., Jachak, A.C., Jordan, W., Landsiedel, R., Morris, J., Patri, A., Pounds, J.G., de Vizcaya Ruiz, A., Shvedova, A., Tanguay, R., Tatarazako, N., van Vliet, E., Walker, N.J., Wiesner, M., Wilcox, N., and Zurlo, J. (2011) Nanotoxicology: "The end of the beginning" - Signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials. Altex. 28(3):236-241.
Abstract
In October 2010, a group of experts met as part of the transatlantic think tank for toxicology (t4) to exchange ideas about the current status and future of safety testing of nanomaterials. At present, there is no widely accepted path forward to assure appropriate and effective hazard identification for engineered nanomaterials. The group discussed needs for characterization of nanomaterials and identified testing protocols that incorporate the use of innovative alternative whole models such as zebrafish or C. elegans, as well as in vitro or alternative methods to examine specific functional pathways and modes of action. The group proposed elements of a potential testing scheme for nanomaterials that works towards an integrated testing strategy, incorporating the goals of the NRC report Toxicity Testing in the 21st Century: A Vision and a Strategy by focusing on pathways of toxic response, and utilizing an evidence-based strategy for developing the knowledge base for safety assessment. Finally, the group recommended that a reliable, open, curated database be developed that interfaces with existing databases to enable sharing of information.
Errata / Notes
t4 workshop report
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping