FIGURE SUMMARY
Title

Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines

Authors
Lam, S.H., Lee, S.G., Lin, C.Y., Thomsen, J.S., Fu, P.Y., Murthy, K.R., Li, H., Govindarajan, K.R., Nick, L.C., Bourque, G., Gong, Z., Lufkin, T., Liu, E.T., and Mathavan, S.
Source
Full text @ BMC Med. Genomics
Fig. 1

Expression profile of zebrafish estrogen-responsive genes. A. Total of 1092 estrogen-responsive genes (715 up-regulated and 377 down-regulated) following E2 treatment which are also partially suppressed or normalized in E2+ICI treatment. B. Selected estrogen-responsive genes having their estrogen-induced transcriptional changes almost completely suppressed or normalized by E2+ICI treatment. C. Selected estrogen-responsive genes having their estrogen-induced transcriptional changes partially suppressed by E2+ICI treatment.
Fig. 2

Validation of microarray data by qRT-PCR. A. Expression levels of vtg1 and vtg3 and B. esr1. C. Selection of representative up-regulated genes. D. Selection of representative down-regulated genes. The data represents average of 3 replicates and presented as mean and standard deviation.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Med. Genomics
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